C. Moran

Building transformative city-university sustainability partnerships: the Audacious Partnerships Process

Lauren Withycombe Keeler, Fletcher D. Beaudoin, Abril Cid, Robert Cowley et autres

City governments and urban universities are well-positioned to play critical roles in advancing urban sustainability transformations. However, in partnering, cities and universities often focus efforts on discrete sustainability-related projects, neglecting the development of long-term relationships and deep, inter-organizational ties that can allow …

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The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins

Michael C. Paul-Smith, Kamila M Pytel, Jean‐François Gélinas, Jenny McIntosh et autres

We have shown that a lentiviral vector (rSIV.F/HN) pseudotyped with the F and HN proteins from Sendai virus generates high levels of intracellular proteins after lung transduction. Here, we evaluate the use of rSIV.F/HN for production of secreted proteins. We assessed whether …

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Yours Faithfully Edna Welthorpe (Mrs) [the event]

Chris John Shepherd, Emma Parker, Alec Baldwin, Jessie Armstrong et autres

Co-creator and co-curator of Yours Faithfully Edna Welthorpe (Mrs) with Dr Emma Parker of Leicester University. Yours Faithfully is a tribute project to the 60's author and playwright Joe Orton. \n \nTo mark the 50th anniversary of the passing of Joe Orton. …

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

Eric W.F.W. Alton, Jeffrey Matthijn Beekman, A. Christopher Boyd, June Brand et autres

We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemagglutinin/Neuraminidase protein (HN)-pseudotyped lentiviral vectors …

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S127 Gene therapy for alpha-1-antitrypsin deficiency using a pseudotyped lentivirus vector

MC Paul-Smith, Jean‐François Gélinas, Kamila M Pytel, Mark Y. Chan et autres

Introduction and objectives A protease/anti-protease imbalance is a characteristic feature of inflammatory lung diseases such as cystic fibrosis (CF) and alpha-1-antitrypsin deficiency related emphysema. A recent trial of alpha-1-antitrypsin (hAAT) enzyme replacement therapy (ERT) suggested that hAAT can slow the progression of …

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S56 Moving lentiviral-based gene therapy into a first-in-man CF trial

Uta Griesenbach, JM Beekman, A. Christopher Boyd, Mark Y. Chan et autres

The UK CF Gene Therapy Consortium has developed a pipeline of vectors to deliver CFTR into the airway epithelium. The first of these (plasmid/liposome complexes) recently completed a Phase IIb trial. Anticipating that increased efficiency of gene transfer will be required, we …

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370. F/HN Pseudotyped Lentivirus Generates Therapeutically Relevant and Long-Lasting Alpha-1-Antitrypsin Expression in Mouse Lung

Michael C. Paul-Smith, Jean‐François Gélinas, Kamila M Pytel, Mario Chan et autres

A protease/anti-protease imbalance is a characteristic feature of inflammatory lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). However, alpha-1-antitrypsin (AAT) enzyme replacement therapy (ERT) trials have not shown conclusive evidence of a therapeutic benefit. This may be …

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Six detached white-dwarf close binaries

Luisa Morales-Rueda, Thomas R. Marsh, Pierre F L Maxted, Gijs Nelemans et autres

We determine the orbits of four double degenerate systems (DDs), composed of two white dwarfs, and of two white dwarf -- M dwarf binaries. The four DDs, WD1022+050, WD1428+373, WD1824+040, and WD2032+188, show orbital periods of 1.157155(5) d, 1.15674(2) d, 6.26602(6) d …

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The mass ratio distribution of short-period double degenerate stars

Pierre F L Maxted, Thomas R. Marsh, C. Moran

Short-period double degenerates (DDs) are close white dwarf–white dwarf binary stars which are the result of the evolution of interacting binary stars. We present the first definitive measurements of the mass ratio for two DDs, WD 0136+768 and WD 1204+450, and an …

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Radial velocity measurements of white dwarfs

Pierre F L Maxted, Thomas R. Marsh, C. Moran

We present 594 radial velocity measurements for 71 white dwarfs obtained during our search for binary white dwarfs and not reported elsewhere. We identify three excellent candidate binaries, which require further observations to confirm our preliminary estimates for their orbital periods, and …

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Hα-Emission Doppler Tomography of Long-Period Cataclysmic Variable Stars

Rachel North, Thomas R. Marsh, C. Moran, Ulrich C. Kolb et autres

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The triple degenerate star WD 1704+481

Pierre F L Maxted, Thomas R. Marsh, C. Moran, Zhanwen Han

WD 1704+481 is a visual binary in which both components are white dwarfs. We present spectra of the Hα line of both stars which show that one component (WD 1704+481.2=Sanduleak B=GR 577) is a close binary with two white dwarf components. Thus, …

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