Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma
Ashley Vardon, Scott Haston, Hiba Hamdi, Grace Cooksley et autres
Diffuse midline gliomas (DMGs) with histone H3K27M mutations represent a devastating paediatric brain cancer characterised by abysmal prognosis and limited treatment options. The only approved treatment is radiotherapy (RT), but most of the tumours relapse with fatal consequences. The effects of RT …
gb, fr, us, es (code pays fourni par la source)
2 citations
Scientific Reports