Marilea Lezzi

Screening practices for diabetic peripheral neuropathy in pediatric type 1 diabetes: a nationwide survey by the ISPED Diabetes Study Group

Bruno Bombaci, Marta Bassi, Valeria Castorani, Francesca Di Candia et autres

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Long-term efficacy and safety of Control-IQ technology in younger children with type 1 diabetes in Italy (2020–2023): a longitudinal multicentre real-world study

Valentino Cherubini, Roberto Franceschi, Andrea Fargalli, Marta Bassi et autres

Background: Automated insulin delivery (AID) systems have demonstrated significant improvements in glycemic control in children and adults with type 1 diabetes, but long-term real-world data in preschool-aged children remain limited, particularly in Europe, where Control-IQ is not approved for children under 6 …

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Retrospective Analysis of Vitamin D Levels in Girls with Idiopathic Central Precocious Puberty: A Potential Role in Pubertal Activation?

Giorgio Sodero, Luigi Antonio Moscogiuri, Anna Camporeale, Aniello Meoli et autres

Objective: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and clinical, hormonal, and auxological features in girls with idiopathic central precocious puberty (CPP). Methods: This retrospective study included 122 girls diagnosed with idiopathic CPP. Participants were stratified into three groups …

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Distinguishing organic from idiopathic central precocious puberty: clinical characteristics and predictive factors for organic etiology in a multicenter Italian cohort study

Giorgio Sodero, Marilea Lezzi, Luigi Antonio Moscogiuri, Elena Malavolta et autres

OBJECTIVES: Central precocious puberty (CPP) is characterized by the early onset of secondary sexual characteristics before the age of 8 in girls and 9 in boys. While rapid progression of sexual development may indicate an underlying organic cause, such as the presence …

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Evaluation of an Automated Insulin Delivery System in the Management of Postprandial Glucose Levels During a Pediatric School Camp: The Control-IQ Potato Challenge

Stefano Passanisi, Bruno Bombaci, Mattia Papa, Serena Rollato et autres

Background: Potatoes are a staple food, especially in pediatric populations, but they pose distinct challenges for individuals with type 1 diabetes (T1D). This study evaluated glycemic responses in youth with T1D using a second-generation automated insulin delivery system after consuming potatoes prepared …

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Efficacy and Safety of Growth Hormone (GH) Therapy in Patients with SHOX Gene Variants

Giorgio Sodero, Federica Arzilli, Elena Malavolta, Marilea Lezzi et autres

BACKGROUND: Among the potential indications for growth hormone (GH) therapy is the presence of mutations in the SHOX (short stature homeobox-containing) gene, located in the telomeric pseudotautosomal region (PAR1) on the short arm of both sex chromosomes. Despite general recommendations supporting GH …

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Prevalence of Hypothalamic–Pituitary Abnormalities in Pediatric Patients with Growth Hormone Deficiency

Giorgio Sodero, Luigi Antonio Moscogiuri, Marilea Lezzi, Fabio Comes et autres

Growth hormone deficiency (GHD) is a key differential diagnosis in children with proportionate short stature. While brain magnetic resonance imaging (MRI) is recommended for all confirmed GHD cases to rule out hypothalamic-pituitary anomalies, its universal application remains debated We conducted a retrospective, …

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Diabetes Mellitus Diagnosed in Childhood and Adolescence With Negative Autoimmunity: Results of Genetic Investigation

Marilea Lezzi, Concetta Aloi, Alessandro Salina, Martina Fragola et autres

Monogenic diabetes is a rare form of diabetes, accounting for approximately 1% to 6% of pediatric diabetes patients. Some types of monogenic diabetes can be misdiagnosed as type 1 diabetes in children or adolescents because of similar clinical features. Identification of the …

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Increased Frequency of Diabetic Ketoacidosis: The Link With COVID-19 Pandemic

Giuseppe d’Annunzio, Marta Bassi, Elena Lucia De Rose, Marilea Lezzi et autres

Aims: Diabetic ketoacidosis is the most severe metabolic derangement due to prolonged insulin deficiency as in type 1 diabetes. Diabetic ketoacidosis, a life-threatening condition, is often diagnosed late. A timely diagnosis is mandatory to prevent its consequences, mainly neurological. The COVID-19 pandemic …

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A Comparison of Two Hybrid Closed-Loop Systems in Italian Children and Adults With Type 1 Diabetes

Marta Bassi, Marsida Teliti, Marilea Lezzi, Arianna Iosca et autres

Tandem Control-IQ and Minimed 780G represent the most Advanced Hybrid Closed Loop (AHCL) systems currently available in pediatric and adult subjects with Type 1 Diabetes (T1D). We retrospectively compared clinical and continuous glucose monitoring data from 51 patients who upgraded to Minimed …

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Antibiotic susceptibility of Staphylococcus aureus isolated from skin lesions in children. A retrospective analysis from a tertiary care Italian pediatric hospital

Marilea Lezzi, Roberto Bandettini, Elisabetta Ugolotti, Carolina Saffioti et autres

Antibiotic susceptibility of S. aureus was retrospectively assessed in 1833 strains isolated from skin lesions observed in an Italian tertiary care hospital. Methicillin resistance was more frequent in outpatients than in inpatients (18% vs. 14%, p = 0.04) as well as resistance …

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Antibiotic Susceptibility of Staphylococcus Aureus Isolated from Skin Lesions in Children. A Retrospective Analysis from a Tertiary Care Italian Pediatric Hospital

Marilea Lezzi, Roberto Bandettini, Elisabetta Ugolotti, Carolina Saffioti et autres

Abstract Background: knowledge on antibiotic susceptibility of S.aureus strains isolated from skin lesions in pediatric Italian patients is limited.Methods: retrospective analysis of antibiotic susceptibility of S.aureus strains isolated from skin infections observed from January 2013 to June 2019 at the IRCCS Istituto …

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