Fanglu Chi

Ultrasound-Triggered NO Release to Promote Axonal Regeneration for Noise-Induced Hearing Loss Therapy

Binjun Chen, Yanhong Sun, Haojie Sun, Ning Cong et autres

Intense noise poses a threat to spiral ganglion neurons (SGNs) in the inner ear, often resulting in limited axonal regeneration during noise injury and leading to noise-induced hearing loss (NIHL). Here, we propose an ultrasound-triggered nitric oxide (NO) release to enhance the …

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A 3D and Explainable Artificial Intelligence Model for Evaluation of Chronic Otitis Media Based on Temporal Bone Computed Tomography: Model Development, Validation, and Clinical Application

Binjun Chen, Yike Li, Yu Sun, Haojie Sun et autres

BACKGROUND: Temporal bone computed tomography (CT) helps diagnose chronic otitis media (COM). However, its interpretation requires training and expertise. Artificial intelligence (AI) can help clinicians evaluate COM through CT scans, but existing models lack transparency and may not fully leverage multidimensional diagnostic …

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Detection of SARS‐CoV‐2 virus in middle ear effusions and its association with otitis media with effusion

Xiao Fu, Zhujian Wang, Binjun Chen, Haojie Sun et autres

A large-scale outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) occurred in Shanghai, China, in early December 2022. To study the incidence and characteristics of otitis media with effusion (OME) complicating SARS-CoV-2, we collected 267 middle ear effusion (MEE) samples and …

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Microscopic Versus Endoscopic Ear Surgery for Early-Stage Glomus Tympanicum Tumors

Xiao Fu, Jingfang Wu, Jihan Lyu, Binjun Chen et autres

Purpose: Glomus tympanicum tumors are benign primary tumors of the middle ear that can be completely removed using modern surgery. We compared endoscopic ear surgery (EES) to traditional microscopic ear surgery (MES) in terms of the removal of early-stage glomus tympanicum tumors. …

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A 3D and Explainable Artificial Intelligence Model for Evaluation of Chronic Otitis Media Based on Temporal Bone Computed Tomography: Model Development, Validation, and Clinical Application (Preprint)

Binjun Chen, Yike Li, Yu Sun, Haojie Sun et autres

BACKGROUND Temporal bone computed tomography (CT) helps diagnose chronic otitis media (COM). However, its interpretation requires training and expertise. Artificial intelligence (AI) can help clinicians evaluate COM through CT scans, but existing models lack transparency and may not fully leverage multidimensional diagnostic …

A New Floating Piezoelectric Microphone for Fully Implantable Cochlear Implants in Middle Ear

Xinda Xu, W. Zhang, Xian‐Hao Jia, Yongzhen Wu et autres

OBJECTIVE: Our team designed a long-lasting, well-sealed microphone, which uses laser welding and vacuum packaging technology. This study examined the sensitivity and effectiveness of this new floating piezoelectric microphone (NFPM) designed for totally implantable cochlear implants (TICIs) in animal experiments and intraoperative …

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Involvement of Dmp1 in the Precise Regulation of Hair Bundle Formation in the Developing Cochlea

Yanmei Wang, Jihan Lyu, Xiaoqing Qian, Binjun Chen et autres

Dentin matrix protein 1 (Dmp1) is a highly phosphorylated, extracellular matrix protein that is extensively expressed in bone and teeth but also found in soft tissues, including brain and muscle. However, the functions of Dmp1 in the mice cochlea are unknown. Our …

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Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway

Yu Zheng, Na Gao, Weixun Zhang, Rui Ma et autres

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Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury

Yu Zheng, Xinda Xu, Fanglu Chi, Ning Cong

Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction. Previous studies have shown that different types of cell death, including apoptosis, necrosis, and autophagy, can occur during I/R …

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High frequency hearing loss may act as a screening index evaluating otolith function in vertigo patients with normal semi-circular canal function

Liang Tian, Zhong‐Chun Chen, Jinyu Wang, Lei Zhang et autres

Objective To investigate whether otolith dysfunction is related to hearing impairment in vertigo patients with normal semicircular canal function, and to clarify the types of hearing impairment that may be related to otolith organ damage. Methods The demographic data, pure tone threshold …

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Evaluation of the hearing preservation and tissue response of dexamethasone and hyaluronic acid delivery during cochlear implantation on cats in a three-month period study

Nirmal Thapa, Yu Zheng, Na Gao, Fanglu Chi

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Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational study

Yanqing Fang, Xiaoting Cheng, Wenhui Peng, Xueying Chen et autres

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