William B. Snyder

Supplementary Figures S1-S6 from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature

Alberto Visintin, Kelly Knowlton, Edyta Tyminski, Chi‐Iou Lin et autres

Supplementary Figures S1-S6. Supplementary Figure S1. Liquid chromatography electrospray ionization tandem mass spectrometry analysis; Supplementary Figure S2. TM4SF1 expression in human breast and colon cancers; Supplementary Figure S3A. Clearance of anti-TM4SF1 antibody from HUVEC surface; Supplementary Figure S3B. Uptake of anti-TM4SF1 antibody …

Prediction for 2-Year Vision Outcomes Using Early Morphologic and Functional Responses in the Comparison of Age-related Macular Degeneration Treatments Trials

Katie Xue, Peiying Hua, Maureen G. Maguire, Ebenezer Daniel et autres

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Predominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials

Jason Q. Core, Maxwell Pistilli, Peiying Hua, Ebenezer Daniel et autres

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Early Brain microRNA/mRNA Expression is Region-Specific After Neonatal Hypoxic-Ischemic Injury in a Mouse Model

Eric S. Peeples, Namood-e Sahar, William B. Snyder, Károly Mirnics

Background: MicroRNAs (miRNAs) may be promising therapeutic targets for neonatal hypoxic-ischemic brain injury (HIBI) but targeting miRNA-based therapy will require more precise understanding of endogenous brain miRNA expression. Methods: Postnatal day 9 mouse pups underwent HIBI by unilateral carotid ligation + hypoxia …

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Intranasal Administration of Extracellular Vesicles Mitigates Apoptosis in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury

Abby Lawson, William B. Snyder, Eric S. Peeples

INTRODUCTION: Neonatal hypoxic-ischemic brain injury (HIBI) results in significant morbidity and mortality despite current available therapies. Seeking a potential supplemental therapy for HIBI, we investigated the neuroprotective effects of extracellular vesicles derived from neural stem cells (NSC-EVs) and hypoxia-preconditioned brain cells (brain-EVs). …

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Supplementary Material for: Intranasal Administration of Extracellular Vesicles Mitigates Apoptosis in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury

Adam Lawson, William B. Snyder

Introduction: Neonatal hypoxic-ischemic brain injury (HIBI) results in significant morbidity and mortality despite current available therapies. Seeking a potential supplemental therapy for HIBI, we investigated the neuroprotective effects of extracellular vesicles derived from neural stem cells (NSC-EVs) and hypoxia-preconditioned brain cells (brain-EVs). …

Temporal brain microRNA expression changes in a mouse model of neonatal hypoxic–ischemic injury

Eric S. Peeples, Namood-e Sahar, William B. Snyder, Károly Mirnics

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Alcohol dependence activates ventral tegmental area projections to central amygdala in male mice and rats

Elizabeth M. Avegno, Chelsea R. Kasten, William B. Snyder, Leslie K. Kelley et autres

The neural adaptations that occur during the transition to alcohol dependence are not entirely understood but may include a gradual recruitment of brain stress circuitry by mesolimbic reward circuitry that is activated during early stages of alcohol use. Here, we focused on …

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Alcohol dependence activates ventral tegmental area projections to central amygdala in male mice and rats

Elizabeth M. Avegno, Chelsea R. Kasten, William B. Snyder, Leslie K. Kelley et autres

Abstract The neural adaptations that occur during the transition to alcohol dependence are not entirely understood, but may include a gradual recruitment of brain stress circuitry by mesolimbic reward circuitry that is activated during early stages of alcohol use. Here, we focused …

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Therapeutic Effects of FGF23 c-tail Fc in a Murine Preclinical Model of X-Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption

Kristen Johnson, Kymberly K. Levine, Joseph A. Sergi, Jean Chamoun et autres

Fibroblast growth factor 23 (FGF23) is the causative factor of X-linked hypophosphatemia (XLH), a genetic disorder effecting 1:20,000 that is characterized by excessive phosphate excretion, elevated FGF23 levels and a rickets/osteomalacia phenotype. FGF23 inhibits phosphate reabsorption and suppresses 1α,25-dihydroxyvitamin D (1,25D) biosynthesis, …

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Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

Alex Willoughby, Gui‐Shuang Ying, Cynthia A. Toth, Maureen G. Maguire et autres

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Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature

Alberto Visintin, Kelly M. Knowlton, Edyta Tyminski, Chi‐Iou Lin et autres

Antibody-drug conjugates (ADC) represent a promising therapeutic modality for managing cancer. Here, we report a novel humanized ADC that targets the tetraspanin-like protein TM4SF1. TM4SF1 is highly expressed on the plasma membranes of many human cancer cells and also on the endothelial …

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