Jonathan M. Gibbins

Recombinant von Willebrand Factor (vonicog alfa) reduces platelet inhibition caused by antiplatelet drugs and has potential as an acute haemostatic agent

Michael Desborough, Joanne L. Mitchell, Polly Whitworth, Ashifa Al Juwaiser et autres

Not available.

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A computational framework for the investigation of phosphoinositide regulation

Hilaire Yam Fung Cheung, Chukiat Tantiwong, D. D. Kale, Jonathan M. Gibbins et autres

Phosphoinositides are a group of interconvertible lipids that are located in the membrane of eukaryotic cells. They turnover via complex network of reactions (called the phosphoinositide pathway) that respond rapidly to regulate many aspects of a cell's response to their environment. Given …

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Extended Modelling of Molecular Calcium Signalling in Platelets by Combined Recurrent Neural Network and Partial Least Squares Analyses

Chukiat Tantiwong, Hilaire Yam Fung Cheung, Joanne L. Dunster, Jonathan M. Gibbins et autres

Platelets play critical roles in haemostasis and thrombosis. The platelet activation process is driven by agonist-induced rises in cytosolic [Ca2+]i, where the patterns of Ca2+ responses are still incompletely understood. In this study, we developed a number of techniques to model the …

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Using platelet function analysis to personalise anti-thrombotic drug therapies

Jonathan M. Gibbins

Evidence for control of cerebral neurovascular function by circulating platelets in healthy older adults

Gabriella M. K. Rossetti, Joanne L. Dunster, Aamir Sohail, B. A. Williams et autres

Platelets play a vital role in preventing haemorrhage through haemostasis, but complications arise when platelets become overly reactive, leading to pathophysiology such as atherothrombosis. Elevated haemostatic markers are linked to dementia and predict its onset in long-term studies. Despite epidemiological evidence, the …

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High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

Marcin A. Sowa, Yan Wu, Jan van Groningen, Ying Tong Di et autres

BACKGROUND AND PURPOSE: The C-type lectin-like receptor-2 (CLEC-2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis. Activation of CLEC-2 …

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Mistakes in Action: On Clarifying the Phenomenon of Goal-Directedness

Jonathan Hill, David S. Oderberg, Christopher J. Austin, François Cinotti et autres

Abstract Common sense tells us that biological systems are goal-directed, and yet the concept remains philosophically problematic. We propose a novel characterization of goal-directed activities as a basis for hypothesizing about and investigating explanatory mechanisms. We focus on survival goals such as …

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Getting it Wrong: Biological Mistake-Making as a Cross-System, Cross-Scale Phenomenon

David S. Oderberg, Jonathan Hill, Ingo Bojak, Jonathan M. Gibbins et autres

The making of mistakes by organisms and living systems generally is an underexplored way of conceptualising biology and organising experimental research. We set out an informal account of biological mistakes and why they should be taken seriously in biological investigation. We then …

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Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62

Kirk A. Taylor, Amro Elgheznawy, Recep Adiyaman, Tyler L. Horn et autres

Connexin (Cx) gap junction proteins are expressed by a multitude of cells and function as plasma membrane hemichannels or dock to form intercellular communication tunnels. Whilst Cx43 has garnered considerable attention, less is known about the structure and function of Cx62 channels. …

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Development of Zafirlukast Analogues for Improved Antithrombotic Activity Through Thiol Isomerase Inhibition

Justine A. Keovilay, Kaitlind C. Howard, Kirk A. Taylor, Sabeeya Khan et autres

BACKGROUND: Thiol isomerases play essential and nonredundant roles in platelet activation, aggregation, and thrombus formation. Thiol isomerase inhibitors have the potential to overcome the 2 major drawbacks of current antithrombotic therapies, as they target both arterial and venous thrombosis without enhancing bleeding …

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Extended Modelling of Platelet Calcium Signaling by Combined Recurrent Neural Network and Partial Least Squares Analyses

Chukiat Tantiwong, Hilaire Yam Fung Cheung, Joanne L. Dunster, Jonathan M. Gibbins et autres

Abstract Platelets play critical roles in hemostasis and thrombosis. The platelet activation process is driven by agonist-induced rises in cytosolic [Ca 2+ ] i , where the patterns of Ca 2+ responses are still incompletely understood. In this study, we developed a …

nl, gb (code pays fourni par la source)

Illustrated capsules from the Advanced Course in Platelet Research

Christian Andrea Di Buduo, Vittorio Abbonante, Alessandro Malara, Alessandra Balduini et autres

This series of illustrated capsules summarizes the presentations made by the speakers at the first International Advanced Course in Platelet Research held in Murcia (Spain) from 27 to 28 September, 2024. This is the first course to receive a Fundamental Research Workshop …

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