Marta Costa Braga

Mechanical circulatory support as a cornerstone in advanced heart failure and transplantation

Marta Costa Braga, Ana Isabel Pinho, Ulrich P. Jorde, José González‐Costello

Orthotopic heart transplantation remains the gold standard for managing selected patients with end-stage heart failure (HF) who are unresponsive to conventional therapies. Mechanical circulatory support (MCS), encompassing durable (dMCS) and temporary (tMCS) devices, has become a cornerstone in bridging patients to transplant …

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Cardiac involvement of monkeypox

Ana Isabel Pinho, Marta Costa Braga

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List of contributors

Jônatas Santos Abrahão, Hoda Ali Ahmed Shiba, Tareq Mohammed Ali AL-Ahdal, Víctor Alegre de Miquel et autres

PET imaging of PD-L1 expression in brain tumours

Gitanjali Sharma, Chiara Da Pieve, David R. Turton, Marta Costa Braga et autres

Immuno-PET Imaging of Tumour PD-L1 Expression in Glioblastoma

Gitanjali Sharma, Marta Costa Braga, Chiara Da Pieve, Wojciech Szopa et autres

There is no established method to assess the PD-L1 expression in brain tumours. Therefore, we investigated the suitability of affibody molecule (ZPD-L1) radiolabelled with F-18 (Al18F) and Ga-68 to measure the expression of PD-L1 in xenograft mouse models of GBM. Mice bearing …

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Acute total occlusion of the unprotected left main coronary artery: Patient characteristics and outcomes

J Calvao, Marta Costa Braga, Mariana Brandão, Andreia Campinas et autres

Acute total occlusion of the unprotected left main coronary artery (LMCA) is a dramatic event. There are limited data regarding this population. We aimed to describe the clinical presentation and outcomes of patients and to determine predictors of in-hospital mortality. This retrospective …

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Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response

André Santa Cruz, Ana Mendes‐Frias, Marne Azarias-da-Silva, Sónia André et autres

Abstract Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2 condition (PASC) that persists for months after infection. Here we evaluate the immune response in convalescent individuals with PASC compared to convalescent asymptomatic and uninfected participants, six months following their …

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The role of comorbidities in acute heart failure outcomes

Marta Costa Braga

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Prediction of Noninvasive Ventilation Failure in COVID-19 Patients: When Shall We Stop?

Luís Neves da Silva, Ricardo Costa, Ana Sá, Ana Mosca et autres

INTRODUCTION: In coronavirus disease 2019 (COVID-19), there are no tools available for the difficult task of recognizing which patients do not benefit from maintaining respiratory support, such as noninvasive ventilation (NIV). Identifying treatment failure is crucial to provide the best possible care …

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Epigenetic potentiation of somatostatin-2 by guadecitabine in neuroendocrine neoplasias as a novel method to allow delivery of peptide receptor radiotherapy

Joanne S. Evans, Jamie Beaumont, Marta Costa Braga, Nahal Masrour et autres

Background Somatostatin receptor-2 (SSTR2) is expressed on cell surface of neuroendocrine neoplasias; its presence is exploited for the delivery of peptide receptor radionuclide therapy (PRRT). Patients with no or low expression of SSTR2 are not candidates for PRRT. SSTR2 promotor undergoes epigenetic …

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Acute Myocarditis

Ana Isabel Pinho, Marta Costa Braga, Mariana Vasconcelos, Cátia Costa Oliveira et autres

A 31-year-old male patient with confirmed monkeypox infection developed acute myocarditis days after the eruption of skin lesions. Cardiac magnetic resonance study confirmed myocardial inflammation. The patient was treated with supportive care and had full clinical recovery. This case highlights cardiac involvement …

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New Fully Automated Preparation of High Apparent Molar Activity 68Ga-FAPI-46 on a Trasis AiO Platform

Chiara Da Pieve, Marta Costa Braga, David R. Turton, Frank Valla et autres

A large number of applications for fibroblast activation protein inhibitors (FAPI)-based PET agents have been evaluated in conditions ranging from cancer to non-malignant diseases such as myocardial infarction. In particular, 68Ga-FAPI-46 was reported to have a high specificity and affinity for FAP-expressing …

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