Faisal Tarique Khaja

CryoEM Structures of Native Quinol-Dependent Nitric Oxide Reductase in Resting and Quinol-Bound States

Faisal Tarique Khaja, Allegra Mboukou, Louie P. Aspinall, Charlotte E. Hawksworth et autres

High Resolution Image Download MS PowerPoint Slide The membrane-bound quinol-dependent nitric oxide reductases (qNORs), which are members of the respiratory heme-copper oxidase superfamily, are of major importance to food production, environment, and human health. They are unique to bacteria and catalyze N–N …

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Cryo-EM structure of wheat ribosome reveals unique features of the plant ribosomes

Rishi Kumar Mishra, Prafful Sharma, Faisal Tarique Khaja, Adwaith B. Uday et autres

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.

Yeast Eukaryotic Initiation Factor 4B Remodels the MRNA Entry Site on the Small Ribosomal Subunit

Ayushi Datey, Prafful Sharma, Faisal Tarique Khaja, Huma Rahil et autres

Eukaryotic Initiation Factor 4 (eIF4) is a group of factors that activates mRNA for translation and recruit 43S preinitiation complex (PIC) to the mRNA 5' end, forming the 48S PIC. The eIF4 factors include mRNA 5' cap-binding protein eIF4E, ATP-dependent RNA helicase …

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Cryo-EM structure of wheat ribosome reveals unique features of the plant ribosomes

Rishi Kumar Mishra, Prafful Sharma, Faisal Tarique Khaja, Adwaith B. Uday et autres

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.

Cryo-EM structure of wheat ribosome reveals unique features of the plant ribosomes

Rishi Kumar Mishra, Prafful Sharma, Faisal Tarique Khaja, Adwaith B. Uday et autres

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Atomic structure of wheat ribosome reveals unique features of the plant ribosomes

Rishi Kumar Mishra, Prafful Sharma, Faisal Tarique Khaja, Adwaith B. Uday et autres

Abstract Ribosomes from plants have unique plant-specific features that may aid in rapid gene expression and regulation in response to changing environmental conditions due to their sessile nature. Here, we present high-resolution cryo-electron microscopy structures of the 60S and 80S ribosomes from …

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Yeast eukaryotic initiation factor 4B remodels the mRNA entry site on the small ribosomal subunit

Ayushi Datey, Faisal Tarique Khaja, Huma Rahil, Tanweer Hussain

Abstract Eukaryotic initiation factor 4B (eIF4B) belongs to the eIF4 group of factors that help in mRNA recruitment to the ribosomal preinitiation complex (PIC) in all eukaryotic organisms. eIF4B stimulates the helicase activity of eIF4A and helps in the formation of the …

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Structure-function studies reveal ComEA contains an oligomerization domain essential for transformation in gram-positive bacteria

Ishtiyaq Ahmed, Jeanette Hahn, Amy Henrickson, Faisal Tarique Khaja et autres

An essential step in bacterial transformation is the uptake of DNA into the periplasm, across the thick peptidoglycan cell wall of Gram-positive bacteria, or the outer membrane and thin peptidoglycan layer of Gram-negative bacteria. ComEA, a DNA-binding protein widely conserved in transformable …

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A mutation in the ribosomal protein uS12 reveals novel functions of its universally conserved PNSA loop

Madhurima Datta, Maalavika Pillai, Mamata Jayant Modak, Aivar Liiv et autres

Abstract The ribosomal protein uS12 is conserved across all domains of life. Recently, a heterozygous spontaneous mutation in human uS12 (corresponding to R49K mutation immediately downstream of the universally conserved 44PNSA47 loop in Escherichia coli uS12) was identified for causing ribosomopathy, highlighting …

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Structure-Function Studies of the Bacillus subtilis Ric Proteins Identify the Fe-S Cluster-Ligating Residues and Their Roles in Development and RNA Processing

Felix Adusei-Danso, Faisal Tarique Khaja, Micaela DeSantis, Philip D. Jeffrey et autres

Among the phenotypes associated with the inactivation of these proteins are the inability to be genetically transformed or to form biofilms, a decrease in sporulation frequency, and changes in the stability and maturation of multiple RNA species. Despite their importance, the molecular …

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