Mark Dewhurst

Combined Deletion of Hepatic Zo-1 and Zo-2 Induces Loss of Bile Ducts

Jiaping Xu, Noémi Van Hul, Matias J. Caldez, Mark Dewhurst et autres

The application of blood spot technology to determine pharmacokinetic parameters for safety pharmacology studies

Sonia Roberts, Oladipupo Adeyemi, Mark Dewhurst, Jade Barker et autres

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PK/PD Modelling: Validation and use of iterative development of experimental designs

Mark Dewhurst, Neil Attkins, Chantelle Connaughton, Neil Brunton et autres

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Using the conscious telemetered rat for early in vivo ECG safety studies: QT interval measurement and correction

Oladipupo Adeyemi, Sonia Roberts, Mark Dewhurst

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Cardiovascular profiles of beta3 agonists

Joanne L. Leaney, Sonia Roberts, Michelle Hemkens, Julie V. Selkirk et autres

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Structural integration and cardiovascular effects following transplantation of endothelial progenitor cells (EPCs) into the brainstem of rats

Ana Maria Alviar Baquero, Nicolle Kränkel, John Whitaker, Mark Dewhurst et autres

Our evidence indicates that brainstem endothelium is a viable target for controlling arterial pressure. Thus, we have used EPCs to target the brainstem microvasculature in vivo and assessed any effect on cardiovascular function. Bone marrow mononuclear cells from male Wistar rats were …

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Translational pharmacokinetic–pharmacodynamic modelling; application to cardiovascular safety data for PF‐00821385, a novel HIV agent

Grant Langdon, John D. Davis, Lynn McFadyen, Mark Dewhurst et autres

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • While animal toxicology is routinely used for safety screening of compounds prior to their being tested in man, there is very little in the literature on the quantitative translation of cardiovascular drug effects from …

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QA interval as an indirect measure of cardiac contractility in the conscious telemeterised rat: Model optimisation and evaluation

Oladipupo Adeyemi, Sonia Roberts, Jolie Harris, H. West et autres

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Application of modified ECG lead placement technique in rat telemetry safety studies; outcome and potential use

Mark Dewhurst, Oladipupo Adeyemi, Jolie Harris, H. West et autres

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High dose Dofetilide in conscious dogs; development of full concentration-response relationship

Mark Dewhurst, N. Regan, Katie Pettit, Ian D. Lightbown et autres

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IMPACT OF EXPERIMENTAL DESIGN AND PK/PD MODELING ON SAFETY MARGIN ESTIMATION: A CASE STUDY

Mark Dewhurst, Neil Brunton, Joanne L. Leaney, Piet van der Graaf et autres

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Reduced nerve blood flow in diabetic rats: relationship to nitric oxide production and inhibition of aldose reductase

David R. Tomlinson, Mark Dewhurst, Elizabeth Stevens, Nagashige Omawari et autres

This study examined links between impaired nitric oxide production in the sciatic endoneurium, nerve blood flow, and polyol pathway flux, to test the hypothesis that reduced nerve blood flow might be compromised by competition for NADPH between aldose reductase and nitric oxide …

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