Jiwen Bao

Artesunate Enhances DUSP1 ‐Dependent Mitochondrial Integrity to Mitigate Renal Fibrosis in Diabetic Kidney Disease

Zikang Liu, Hongtu Hu, Yuxuan Jin, Jiwen Bao et autres

Renal fibrosis is a hallmark of diabetic kidney disease (DKD), and currently available therapies offer limited efficacy. Artesunate (ART), a repurposed antimalarial agent, has recently demonstrated potential in mitigating renal fibrosis. This study aimed to investigate whether ART protects mitochondrial integrity and …

cn, gb (code pays fourni par la source)

sPLA2-IB and PLA2R Mediate Aberrant Glucose Metabolism in Podocytes via Hyperactivation of the mTOR/HIF-1α Pathway

Jiwen Bao, Binbin Dai, Liyan Yang, Zikang Liu et autres

Secretory phospholipase A2 group IB (sPLA2-IB) and M-type phospholipase A2 receptor (PLA2R) are closely related to proteinuria and idiopathic membranous nephropathy (IMN). Podocytes are important components of the glomerular filtration barrier and glucose metabolism, including glycolysis and tricarboxylic acid (TCA) cycle, is …

cn (code pays fourni par la source)

T cell metabolism in kidney immune homeostasis

Zikang Liu, Binbin Dai, Jiwen Bao, Yangbin Pan

Kidney immune homeostasis is intricately linked to T cells. Inappropriate differentiation, activation, and effector functions of T cells lead to a spectrum of kidney disease. While executing immune functions, T cells undergo a series of metabolic rewiring to meet the rapid energy …

cn (code pays fourni par la source)

Analysis of the Efficacy and Renal Prognosis of a Reduced-Dose Immunosuppressive Regimen of Mild to Moderate ANCA-Associated Renal Vasculitis

Ziyang Li, Jiwen Bao, Huanzhen Yao, Minfang Zhang et autres

Abstract ObjectivesSecondary infection caused by high-dose immunosuppressive therapy is one of the most common causes of death in patients with ANCA-associated vasculitis. This study aimed to explore whether reduced-dose immunosuppressive therapy can achieve the same efficacy while reducing secondary infection in mild …

cn (code pays fourni par la source)

Reduced Regime of Glucocorticoids and Cyclophosphamide for Mild ANCA-Associated Renal Vasculitis May Delay Deterioration of Renal Function

Ziyang Li, Jiwen Bao, Huanzhen Yao, Qin Wang et autres

cn (code pays fourni par la source)

Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis

Guanwen Huang, Jiwen Bao, Xinghua Shao, Wenyan Zhou et autres

cn (code pays fourni par la source)