Artur Lichtenberg

Smooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D–3D proteomics

Julia Hesse, Ulrike Resch, Lotte Görtz, Sarah Lang et autres

Vascular smooth muscle cells (VSMCs) are regulators of vascular homeostasis and play a role in cardiovascular diseases, including atherosclerosis and aortic aneurysms. Together with endothelial cells (ECs), they control vascular remodeling by producing extracellular matrix (ECM), regulating the expression of adhesion molecules, …

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Preoperative depressive symptoms predict sustained postoperative inflammation and longer hospital stay after cardiac surgery

Stefan Salzmann, Frank Euteneuer, Ruben Domroese, Udo Boeken et autres

Introduction: Psychological distress is common among patients undergoing cardiac surgery and may influence postoperative recovery and inflammation. This retrospective study examined whether preoperative depressive symptoms predict the postoperative inflammatory response and the length of hospital stay (LOS) in elective cardiac surgery patients. …

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Mid- to long-term results of minimally invasive repair of Barlow’s disease with posterior leaflet resection and chordal transfer

Christina Ballazs, Yukiharu Sugimura, Moritz Benjamin Immohr, Stephan Sixt et autres

OBJECTIVE: Mitral valve repair (MVr) in Barlow's disease (BD) is technically demanding, requires complex repair techniques. Following a previous report including posterior mitral leaflet (PML) resection and chordal transfer plus annuloplasty applicable via minimally invasive approach, herein we present mid to long …

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Anxiety, depression and health-related quality of life in patients with thoracic aortic disease: a longitudinal study in a cardiothoracic outpatient clinic

Ismail Dalyanoglu, Anna Maria Markser, Johannes Nienhaus, Esma Yilmaz et autres

Background: Thoracic aortic diseases (TAD) require complex surgical and longitudinal follow-up care. Evidence on health-related quality of life (HRQoL) and psychological distress in real-world TAD outpatient cohorts remains limited. Objective: To describe longitudinal trajectories of HRQoL and psychological distress in patients with …

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Impact of leakage on data harmonization in machine learning pipelines in class imbalance across sites

Nicolás Nieto, Simon B. Eickhoff, Christian Jung, Martin Reuter et autres

Due to the cost and complexity of data collection in biomedical domains, it is a common practice to combine data from multiple sites to obtain large datasets required for machine learning. However, undesired site-specific variability presents challenges. Data harmonization aims to address …

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Heart Transplantation in Recipients With Hepatitis B Surface Antigen Positivity: A Single-Center Cohort Analysis

Raphael Phinicarides, T. Zeus, Fabian Voß, M. Kelm et autres

All articles of this category (opens in new window) Background: Heart transplantation (HTX) is the definitive therapy for end-stage heart failure. Hepatitis B virus (HBV) raises concern due to the risk of reactivation under lifelong immunosuppression. Guidelines recommend inclusion of HBV-positive recipients …

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Purinergic signaling modulates endothelial-to-mesenchymal transition in human aortic valve endothelial cells

Vera Schmidt, Andreas Weber, Artur Lichtenberg, Jürgen Schrader et autres

Endothelial-to-mesenchymal transition (EndMT) is a phenotypic switch in which endothelial cells acquire mesenchymal characteristics, involving both functional and morphological changes. While EndMT is essential for cardiac development, its aberrant activation contributes to adult cardiovascular pathologies, including calcific aortic valve disease (CAVD). Dysregulation …

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Surgical Therapy of Right‐Sided Infective Endocarditis: Insights From the Multicenter Project of Analysis of Infective Endocarditis in Germany (CAMPAIGN) Study Group

Asen Petrov, Verónica De Angelis, Mateo Marin‐Cuartas, Carolyn Weber et autres

Objectives Right‐sided infective endocarditis (RSIE) is a rare entity seldom requiring surgical therapy. This study compares the outcome following surgery in cases of isolated RSIE (iRSIE) and cases with concomitant left‐sided infective endocarditis (LSIE). Methods A retrospective analysis was performed on the …

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Metformin mitigates aortic valve degeneration in an ex vivo three-dimensional tissue model

Friederike I. Schoettler, Andreas Weber, Vera Schmidt, Sebastian Johannes Bauer et autres

Calcific aortic valve disease (CAVD) is a prevalent valvular disorder that lacks effective pharmacological treatments. Metformin, an oral anti-diabetic drug, has been suggested to protect valvular interstitial cells (VICs) from calcification, but its role in preventing organic phosphate-induced degeneration in VICs and …

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Predictive Value of MELD Score and Charlson Comorbidity Index in Thoracic Aortic Surgery Patients

Ismail Dalyanoglu, Freya Sophie Jenkins, Luis Jaime Vallejo Castano, Esma Yilmaz et autres

Thoracic aortic aneurysms (TAAs) carry a high risk of fatal rupture, necessitating improved preoperative risk stratification. This study evaluates the predictive value of systemic risk scores—specifically the Model for End-Stage Liver Disease (MELD) and the Charlson Comorbidity Index (CCI)—for in-hospital mortality, length …

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Exploring the Safety of Sodium-Glucose Co-Transporter 2 Inhibitors in Left Ventricular Assist Device Patients: Clinical Outcomes in a Multicenter Experience

Sonja Hamed, Nikolaos Kalampokas, Jan Beckendorf, Anna L. Meyer et autres

Heart failure (HF) remains a progressive condition even with optimal medical therapy, often requiring advanced interventions like left ventricular assist devices (LVAD). Recent advancements in HF treatment, including sodium-glucose co-transporter 2 inhibitors (SGLT2i), have demonstrated benefits such as reduced mortality, symptom improvement, …

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„End of life care“ in der Herzchirurgie

Artur Lichtenberg, M Scherner, Stefan Meier, Moritz Blum et autres

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