François Wessels

Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Mark Edwards, Gordon Forbes, Neil Walker, Dion Morton et autres

INTRODUCTION: Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems. Optimal management of perioperative intravenous fluids may reduce mortality rates and improve outcomes from surgery. Previous small trials of cardiac-output guided haemodynamic therapy …

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Noninvasive ventilation for COVID-19-associated acute hypoxaemic respiratory failure: experience from a single centre

Arjjana Sivaloganathan, Myra Nasim-Mohi, Michael M. Brown, Nabil Abdul et autres

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Spirituality in narratives of meaning

François Wessels, Julian C. Müller

This article forms part of a study which was inspired by the ever-growing need for significance expressed both by my life coaching and pastoral therapy clients as well as the need for existential meaning reported both in the lay press and academic …

Is fenofibrate a cost-saving treatment for middle-aged individuals with type 2 diabetes? A South African private-sector perspective

François Wessels

INTRODUCTION: This project was based on the FIELD trial. It is a localisation of the study by Carrington and Stewart. The aim of the original study was to determine the impact of fenofibrate therapy on healthcare costs of middle-aged patients with type …

Perindopril: do randomised, controlled trials support an ACE inhibitor class effect? A meta-analysis of clinical trials.

J. R. Snyman, François Wessels

BACKGROUND: Due to the lack of face-to-face trials between ACE inhibitors, clinicians and third-party funders may assume they provide similar outcomes. As a result, ACE inhibitors may be prescribed interchangeably and deemed to provide the same outcomes for all patients when used …

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Eprosartan in secondary prevention of stroke: the economic evidence.

François Wessels

Intravenous fluid therapy: a randomized controlled trial to investigate the effectiveness of the IV2TM flow medical device

Nesta Fraser, J. R. Snyman, François Wessels, George Nel

OBJECTIVES: To investigate the hypothetical benefits of the IV(2) flow medical device. BACKGROUND: Intravenous fluid administration is a standard hospital procedure with assumed inadequacies. The IV-Event Study [Fraser N, Nel G, Snyman J & Wessels F (2004) IV-EVENT Study: Intravenous Infusion Therapy--Management …

Afrique du Sud (code pays fourni par la source)

Eprosartan in secondary prevention of stroke : the economic evidence : short communication

François Wessels

AT1 receptor blockers--cost-effectiveness within the South African context.

Anderson An, François Wessels, I Moodley, K Kropman

OBJECTIVES: Hypertension is a leading chronic disease in South Africa, Significant mortality results from this condition and from stroke and ischaemic heart disease in which hypertension plays a major role. The objective of this study was to evaluate the evidence for the …

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The cost-effectiveness of isotretinoin in the treatment of acne. Part 2. A chronic medication plan profiling study.

François Wessels, Austen Anderson, K Kropman

OBJECTIVES: Aspects of current clinical practice, needed for a pharmaco-economic model of isotretinoin, were determined from an acne-profiling study on chronic medication plan data. The patient sample was analysed as a whole and as two subgroups, representing isotretinoin and oral antibiotic patients. …

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The cost-effectiveness of isotretinoin in the treatment of acne. Part 3. A cost-minimisation pharmaco-economic model.

François Wessels, Austen Anderson, K Kropman

OBJECTIVES: The cost-effectiveness of systemic isotretinoin therapy in the treatment of moderate to severe acne was assessed in a comparative cost-minimisation analysis. Systemic isotretinoin at the recommended daily dose of 1 mg/kg (cumulative dose of 120 mg/kg) was compared with: (i) oral …

The cost-effectiveness of isotretinoin in the treatment of acne. Part 1. A meta-analysis of effectiveness literature.

François Wessels, Anderson An, K Kropman

OBJECTIVES: This paper reports the results of a meta-analysis of isotretinoin treatment in moderate to severe acne. It forms part of a comprehensive investigation into the cost-effective treatment of acne in South Africa and as such establishes the clinical foundation for an …

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