Aurélie Duthey

Hemostasis defects underlying the hemorrhagic syndrome caused by mammarenaviruses in a cynomolgus macaque model

Blaise Lafoux, Nicolas Baillet, Caroline Picard, Gustave Fourcaud et autres

Viral hemorrhagic fevers (HF) are a group of acute febrile diseases with high mortality rates. Although hemostatic dysfunction appears to be a major determinant of the severity of the disease, it is still unclear what pathogenic mechanisms lead to it. In clinical …

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Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys

Mathieu Mateo, Stéphanie Reynard, Natalia Pietrosemoli, Émeline Perthame et autres

Lassa fever hits West African countries annually in the absence of licensed vaccine to limit the burden of this viral hemorrhagic fever. We previously developed MeV-NP, a single-shot vaccine protecting cynomolgus monkeys against divergent strains one month or more than a year …

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A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates

Stéphanie Reynard, Xavier Carnec, Caroline Picard, Virginie Borges-Cardoso et autres

fr, ru (code pays fourni par la source)

Mouse Models of Henipavirus Infection

Mathieu Iampietro, Stéphane Barron, Aurélie Duthey, Branka Horvat

fr (code pays fourni par la source)

Natural History of Sudan ebolavirus to Support Medical Countermeasure Development

Caroline Carbonnelle, Marie Moroso, Delphine Pannetier, Sabine Godard et autres

Sudan ebolavirus (SUDV) is one of four members of the Ebolavirus genus known to cause Ebola Virus Disease (EVD) in humans, which is characterized by hemorrhagic fever and a high case fatality rate. While licensed therapeutics and vaccines are available in limited …

fr, gb, us (code pays fourni par la source)

Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys

Mathieu Mateo, Jimmy Hortion, Émeline Perthame, Caroline Picard et autres

The area of Lassa virus (LASV) circulation is expanding, with the emergence of highly pathogenic new LASV lineages. Benin recently became an endemic country for LASV and has seen the emergence of a new LASV lineage (VII). The first two outbreaks in …

fr (code pays fourni par la source)

Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys

Mathieu Mateo, Jimmy Hortion, Émeline Perthame, Caroline Picard et autres

The area of Lassa virus (LASV) circulation is expanding, with the emergence of highly pathogenic new LASV lineages. Benin recently became an endemic country for LASV and has seen the emergence of a new LASV lineage (VII). The first two outbreaks in …

A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains

Mathieu Mateo, Stéphanie Reynard, Alexandra Journeaux, Clara Germain et autres

A safe and protective Lassa virus vaccine is crucially needed in Western Africa to stem the recurrent outbreaks of Lassa virus infections in Nigeria and the emergence of Lassa virus in previously unaffected countries, such as Benin and Togo. Major challenges in …

fr (code pays fourni par la source)

Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques

Nicolas Baillet, Stéphanie Reynard, Émeline Perthame, Jimmy Hortion et autres

Lassa virus (LASV) is endemic in West Africa and induces a viral hemorrhagic fever (VHF) with up to 30% lethality among clinical cases. The mechanisms involved in control of Lassa fever or, in contrast, the ensuing catastrophic illness and death are poorly …

fr (code pays fourni par la source)

Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates

Vincent Madelain, Aurélie Duthey, France Mentré, Frédéric Jacquot et autres

fr (code pays fourni par la source)

A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection

Olivier Thaunat, Stéphanie Graff‐Dubois, Nicole Fabien, Aurélie Duthey et autres

fr (code pays fourni par la source)

Intragraft Th17 Infiltrate Promotes Lymphoid Neogenesis and Hastens Clinical Chronic Rejection

Clémence Deteix, Valérie Attuil-Audenis, Aurélie Duthey, Natacha Patey et autres

To evaluate the influence of intragraft inflammatory infiltrate on the course of chronic rejection, 11 human renal grafts, detransplanted for terminal failure, were analyzed. Samples were divided into two groups according to their graft survival (> or < or = 8 y). …

fr, us, Mali, Tunisie, ch (code pays fourni par la source)