Katrin Peckert-Maier

Soluble CD83 Accelerates Wound Healing and Attenuates Inflammatory Responses Induced by Chronic Wound Fluid in a Human 3D in Vitro Wound Healing Model

Christian Hollard, Katrin Peckert-Maier, Moritz Ronicke, Pia Sinner et autres

Chronic wounds, as defined by prolonged inflammation and impaired healing, represent a major and growing healthcare challenge worldwide. Currently, only limited therapeutic options are available to address this condition. This study investigates the potential of soluble CD83 (sCD83), an immunomodulatory molecule, to …

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The Biology of Dendritic Cells: In Health and Disease

Dmytro Royzman, Jan Dörrie, Anita Heiß, Pia Sinner et autres

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Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism

Katrin Peckert-Maier, Andreas B. Wild, Laura Sprißler, Maximilian M. Fuchs et autres

Alterations in macrophage (Mφ) polarization, function, and metabolic signature can foster development of chronic diseases, such as autoimmunity or fibrotic tissue remodeling. Thus, identification of novel therapeutic agents that modulate human Mφ biology is crucial for treatment of such conditions. Herein, we …

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Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis

Pia Sinner, Katrin Peckert-Maier, Hashem Mohammadian, Christine Kuhnt et autres

Microglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue, and the initial response of microglia determines the severity of neuro-inflammatory diseases. The CD83 molecule has been recently shown to modulate the activation status of dendritic cells and …

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CD83 expressed by macrophages is an important immune checkpoint molecule for the resolution of inflammation

Katrin Peckert-Maier, Pia Langguth, Astrid Strack, Lena Stich et autres

Excessive macrophage (Mφ) activation results in chronic inflammatory responses or autoimmune diseases. Therefore, identification of novel immune checkpoints on Mφ, which contribute to resolution of inflammation, is crucial for the development of new therapeutic agents. Herein, we identify CD83 as a marker …

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CD83 acts as immediate early response gene in activated macrophages and exhibits specific intracellular trafficking properties

Pia Langguth, Katrin Peckert-Maier, Philipp Beck, Christine Kuhnt et autres

Macrophages (MΦ) are remarkably plastic cells, which assume phenotypes in every shade between a pro-inflammatory classical activation, and anti-inflammatory or resolving activation. Therefore, elucidation of mechanisms involved in shaping MΦ plasticity and function is key to understand their role during immunological balance. …

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Microglial expression of CD83 governs cellular activation and restrains autoimmune neuroinflammation

Pia Langguth, Katrin Peckert-Maier, Christine Kuhnt, Christina Draßner et autres

Abstract Microglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue and the initial response of microglia determines the severity of neuroinflammatory diseases. CD83 has been associated with early activation of microglia in various disease settings albeit its …

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Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages

Dmytro Royzman, Katrin Peckert-Maier, Lena Stich, Christina König et autres

To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated wound healing not only after systemic but also after …

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The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis

Dmytro Royzman, Darja Andreev, Lena Stich, Katrin Peckert-Maier et autres

Here we show that soluble CD83 induces the resolution of inflammation in an antigen-induced arthritis (AIA) model. Joint swelling and the arthritis-related expression levels of IL-1β, IL-6, RANKL, MMP9, and OC-Stamp were strongly reduced, while Foxp3 was induced. In addition, we observed …

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Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation

Katrin Peckert-Maier, Dmytro Royzman, Pia Langguth, Anita Marosan et autres

Chronic inflammatory diseases and transplant rejection represent major challenges for modern health care. Thus, identification of immune checkpoints that contribute to resolution of inflammation is key to developing novel therapeutic agents for those conditions. In recent years, the CD83 (cluster of differentiation …

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Pre-incubation of corneal donor tissue with sCD83 improves graft survival via the induction of alternatively activated macrophages and tolerogenic dendritic cells

Katrin Peckert-Maier, Alfrun Schönberg, Andreas B. Wild, Dmytro Royzman et autres

Immune responses reflect a complex interplay of cellular and extracellular components which define the microenvironment of a tissue. Therefore, factors that locally influence the microenvironment and re-establish tolerance might be beneficial to mitigate immune-mediated reactions, including the rejection of a transplant. In …

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