Lulu L Cheng

frontMIND: Phase 3 study of tafasitamab (Tafa) plus lenalidomide (Len) and R-CHOP for patients (pts) with newly diagnosed diffuse large B-cell lymphoma (DLBCL).

Georg Lenz, Marek Trněný, John M. Burke, Grzegorz S. Nowakowski et autres

LBA7000 Background: ~40% of DLBCL pts are not cured with first-line (1L) R-CHOP, underscoring a significant unmet need for more effective 1L regimens. Tafa (anti-CD19 mAb) + Len-R-CHOP in the phase 1b First-MIND study demonstrated safety and efficacy in pts with newly …

de, cz, us, gb, it, kr, au, ph, fr (code pays fourni par la source)

Tafasitamab plus lenalidomide and R-CHOP versus R-CHOP for first-line treatment of patients with high-risk diffuse large B-cell lymphoma (frontMIND): a global, phase 3, randomised, double-blind, placebo-controlled trial

Georg Lenz, Marek Trněný, John M Burke, Grzegorz S Nowakowski et autres

Background Approximately 40% of patients with high-risk diffuse large B-cell lymphoma (DLBCL) are not cured with first-line R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone or prednisolone). We aimed to investigate the addition of tafasitamab (an Fc-enhanced anti-CD19 monoclonal antibody) and lenalidomide to …

de, cz, us, gb, it, kr, au, ph, fr, es (code pays fourni par la source)

Developing Presupposition in Mandarin-Speaking Preschoolers: A Dual Analysis of Cognitive and Pragmatic Features in Peer Interactions

Ting Zhang, Lulu L Cheng, Haoran Mao, Yanqin Liu et autres

Presupposition, the linguistic act of treating information as mutually shared or taken for granted, is a cornerstone of effective social interaction. To examine how this competence emerges in early childhood, the present study adopted a mixed-methods approach combining quantitative and qualitative analyses …

cn (code pays fourni par la source)

Classification of depressed and non-depressed MCI and non-depressed cognitively normal individuals using resting-state metrics: A multi-group study with machine learning and graph reinforcement learning

Huibin MA, Jiaying Song, Xiaomeng Xue, Jinying Wu et autres

cn (code pays fourni par la source)

Neurocognitive Trajectories of Scalar Implicature in Mandarin-Speaking Children: ERP Evidence for Attentional Allocation and Pragmatic Recalibration (4–6 Years)

Lulu L Cheng, Wenting Yuan, Haoran Mao, Yule Peng et autres

Despite the centrality of scalar implicature (SI) in pragmatic development, the neurocognitive trajectory of SI processing in Mandarin-speaking children remains underexplored, with existing frameworks inadequately accounting for developmental constraints and cross-linguistic variation. This ERP study maps the neurocognitive trajectory of scalar implicature …

cn (code pays fourni par la source)

Development and validation of a nomogram for early prediction of post-stroke shoulder–hand syndrome: a retrospective cohort study

Xuezheng Li, YU Min, Lulu L Cheng, Yunyun Tao et autres

Background: Shoulder-hand syndrome (SHS) is a prevalent complication following strokes. At present, there is no established and dependable method for early prediction of SHS risk. Thus, we undertook this study to create and validate a nomogram for early prediction of SHS following …

cn (code pays fourni par la source)

Brain activation patterns of figurative language comprehension in individuals with autism spectrum disorder: an activation likelihood estimation meta-analysis

Lulu L Cheng, Jianxin Zhang, Haoran Mao, Xize Jia et autres

Background: Individuals with Autism Spectrum Disorder (ASD) consistently exhibit difficulties in comprehending figurative language. While prior neuroimaging studies have identified discrepancies in brain activation between ASD individuals and neurotypical controls (NCs) during such tasks, the specific and consistent neural patterns underlying these …

cn (code pays fourni par la source)

Network Signatures of Verbal Ability in Autism: A Multisite fMRI Study Using Graph Theory and Machine Learning

Huibin Ma, Jinying Wu, Lanfen Chen, Jiaying Song et autres

Autism spectrum disorder (ASD) is associated with atypical functional connectivity (FC), but its relationship with verbal ability remains unclear. In this study, resting-state functional magnetic resonance imaging (rs-fMRI) data from 219 individuals with ASD and 322 healthy controls (HCs) with valid verbal …

cn (code pays fourni par la source)

Experimental study on the seismic behavior of self-stressing steel slag concrete filled rectangular steel tubular column

L.-P. Liu, Lulu L Cheng, Shijiang Zhang

cn (code pays fourni par la source)

Joint Client Selection and Gradient Optimization for Energy-Efficient Federated Learning in Mobile Edge Computing Networks

Lulu L Cheng, Luxi Cheng, Xiuhua Li, Lingxiao Chen et autres

Federated learning (FL) enables model training on mobile clients (M Cs) while protecting data privacy by keeping the data local. However, the data and system heterogeneity among MCs can significantly undermine model performance, slow convergence, and increase energy consumption. To achieve green …

cn (code pays fourni par la source)

Processing Scalar Inference of the Model ‘Keneng’ in Mandarin Children: ERP Evidence

Lulu L Cheng, Wenting Yuan, Haoran Mao, Bingqi Fu et autres

cn (code pays fourni par la source)

TSA-SAB co-loaded liposome self-dissolving microneedle synergistic delivery system: a breakthrough dual-drug loading strategy for multi-target therapy of hypertrophic scars

Lulu L Cheng, Jiahui Yu, Bijin Yao, Ying-Ping Li et autres

The treatment of hypertrophic scars is constrained by inefficient transdermal delivery and challenges in co-delivery of multiple drugs. Although tanshinone IIA and salvianolic acid B exhibit multi-target antifibrotic potential, their divergent physicochemical properties limit combined application. This study proposes a novel transdermal …

cn (code pays fourni par la source)