Accès ouvert
2025
article
OpenAlex
Liangyu Huang, Chen‐Chen Tan, Wei Xu, Lan Tan et autres
Progranulin (PGRN) and soluble triggering receptor expressed on myeloid cells-2 (sTREM2) are emerging biomarkers of Alzheimer’s disease (AD). This study explores the roles of their interplay in modulating amyloid pathology. We analyzed data from 905 participants (mean age = 62.0) in the …
cn, us, gb
(code pays fourni par la source)
2025
article
OpenAlex
Tuqa Asedi, Sai Kumar Reddy Pasya, Marwan Sabbagh, Hussein Alsadi et autres
To assess the relationship between Insulin Resistance (IR) and clinical outcomes after acute ischemic stroke (AIS) in patients with large vessel occlusion (LVO)
us, jo
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Bhargav Teja Nallapu, Kellen K. Petersen, Tianchen Qian, İdris Demirsoy et autres
BACKGROUND AND OBJECTIVES: Among the participants of Alzheimer disease (AD) treatment trials, 40% do not show cognitive decline over 80 weeks of follow-up. Identifying and excluding these individuals can increase power to detect treatment effects. We aimed to develop machine learning-based predictive …
us, tr
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Chenzhong Yin, Phoebe Imms, Nahian F. Chowdhury, Nikhil N. Chaudhari et autres
Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since birth. Thus, it conveys poorly recent or contemporaneous …
us
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Accès ouvert
2025
article
OpenAlex
Abdulghani Alzamzami, Duaa Ahmed Alshab, Mithaq Abdullah Alrabiea, Fahim Mohammed et autres
Diabetic ketoacidosis represents a critical and potentially life-threatening complication associated with diabetes, predominantly encountered within pediatric populations. This condition is characterized by three key metabolic derangements: hyperglycemia, metabolic acidosis, and the presence of ketone bodies in both blood and urine. The pathophysiology …
sa
(code pays fourni par la source)
2024
book-chapter
OpenAlex
Howard Feldman, Karen Messer, Yuqi Qiu, Marwan Sabbagh et autres
Background: Varoglutamstat is a first-in-class, small molecule being investigated as a treatment for early Alzheimer’s disease (AD). It is an inhibitor of glutaminyl cyclase (QC), the enzyme that post-translationally modifies amyloid-β (Aβ) peptides into a toxic form of pyroglutamate Aβ (pGlu-Aβ) and …
us, cn, ca
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Howard Feldman, Karen Messer, Yuqi Qiu, Marwan Sabbagh et autres
Background: Varoglutamstat is a first-in-class, small molecule being investigated as a treatment for early Alzheimer's disease (AD). It is an inhibitor of glutaminyl cyclase (QC), the enzyme that post-translationally modifies amyloid-β (Aβ) peptides into a toxic form of pyroglutamate Aβ (pGlu-Aβ) and …
us, cn, ca
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca et autres
White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating brain health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH …
de, nl, us, at, ch, sg, ca
(code pays fourni par la source)
2024
article
OpenAlex
Marwan Sabbagh, Cristina Boschini, Sharon Cohen, Magnus Fugger et autres
We investigated the safety of semaglutide in people with T2D and/or overweight/obesity ≥55 years from the phase 3a PIONEER, SUSTAIN and STEP clinical programmes.
us, dk, de
(code pays fourni par la source)
2023
article
OpenAlex
Marwan Sabbagh, Cristina Boschini, Sharon Cohen, Magnus Fugger et autres
Abstract Background The risk of Alzheimer’s disease (AD) increases with age. The glucagon‐like peptide‐1 analogue semaglutide, approved for type 2 diabetes (T2D) and overweight/obesity, is being investigated in the phase 3 evoke and evoke+ trials in people with early AD aged 55‐85 …
us, dk, ca, de
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Marc James Quesnel, Anne Labonté, Cynthia Picard, Henrik Zetterberg et autres
Insulin, insulin-like growth factors (IGF) and their receptors are highly expressed in the adult hippocampus. Thus, disturbances in the insulin-IGF signalling pathway may account for the selective vulnerability of the hippocampus to nascent Alzheimer's disease (AD) pathology. In the present study, we …
ca, us, se, gb, cn, fr
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Yi‐Ting Wang, Joseph Therriault, Stijn Servaes, Cécile Tissot et autres
Females are disproportionately affected by dementia due to Alzheimer's disease. Despite a similar amyloid-β (Aβ) load, a higher load of neurofibrillary tangles (NFTs) is seen in females than males. Previous literature has proposed that Aβ and phosphorylated-tau (p-tau) synergism accelerates tau tangle …
ca, se, gb, no, us
(code pays fourni par la source)