Se Jung Chang

Long-Term Outcomes of Active Surveillance after DOTATATE PET/MRI–Confirmed Gross Total Resection in WHO Grade 2 Meningioma

Jana Ivanidze, Kellen Vo Vu, Umberto Tosi, Se Jung Chang et autres

Long-term outcomes of active surveillance after DOTATATE PET/MRI–confirmed gross total resection in WHO grade 2 meningioma

Jana Ivanidze, Kellen Vo Vu, Umberto Tosi, Se Jung Chang et autres

AbstractAbstract Background Somatostatin receptor 2 (SSTR2), a highly sensitive and specific meningioma biomarker, can be imaged with [68Ga]-DOTATATE PET, improving diagnosis and treatment. The role of postoperative radiotherapy (RT) for WHO grade 2 (WHO-2) meningiomas following gross total resection (GTR) remains controversial. …

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DOTATATE PET/MR Imaging Differentiates Secondary-Progressive from de Novo World Health Organization Grade 3 Meningiomas

Joon Tae Kim, Se Jung Chang, Arsalan Haghdel, Rohan R. Ramakrishna et autres

BACKGROUND AND PURPOSE: WHO grade 3 meningiomas are rare and poorly understood and have a higher propensity for recurrence, metastasis, and worsened clinical outcomes compared with lower-grade meningiomas. The purpose of our study was to prospectively evaluate the molecular profile, PET characteristics, …

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[Ga68] DOTATATE PET/MRI-guided radiosurgical treatment planning and response assessment in meningiomas

Jana Ivanidze, Se Jung Chang, Arsalan Haghdel, Joon Tae Kim et autres

BACKGROUND: Our purpose was to determine the utility of [68Ga]-DOTATATE PET/MRI in meningioma response assessment following radiosurgery. METHODS: Patients with meningioma prospectively underwent postoperative DOTATATE PET/MRI. Co-registered PET and gadolinium-enhanced T1-weighted MRI were employed for radiosurgery planning. Follow-up DOTATATE PET/MRI was performed …

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[68 Ga]-DOTATATE PET/MR-based evaluation of physiologic somatostatin receptor 2 expression in the adult pituitary gland as a function of age and sex in a prospective cohort

Sean Kim, Se Jung Chang, Georgiana Alina Dobri, Sara Strauß et autres

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Bleeding Events After Image-Guided Breast Biopsies: Comparison of Patients Temporarily Discontinuing Versus Maintaining Antithrombotic Therapy During Biopsy

Melissa B. Reichman, Paige McMahon, Michaela Dwyer, Se Jung Chang et autres

The findings support the safety of continuing AT therapy during CNB. Patients who maintain AT therapy should be counseled regarding risk of bruise.

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[68Ga]-DOTATATE PET/MR-based Evaluation of Physiologic Somatostatin Receptor 2 Expression in the Adult Pituitary Gland as a Function of Age and Sex in a Prospective Cohort.

Sean Kim, Se Jung Chang, Georgiana Alina Dobri, Sara Strauß et autres

Abstract Purpose The pituitary gland has the fourth highest physiologic avidity of [68Ga]-DOTATATE. In order to guide our understanding of [68Ga]-DOTATATE PET in clinical contexts, accurate characterization of the normal pituitary gland is first required. This study aimed to characterize the normal …

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327 Radiopathomics: Integration of Advanced Neuroimaging and Molecular Pathology Features in Meningiomas

Arsalan Haghdel, Se Jung Chang, Rohan R. Ramakrishna, Rajiv Magge et autres

OBJECTIVES/GOALS: Our overall objective is to investigate the relationship between radiologic features of meningioma with recently identified histopathological and molecular biomarkers, and to apply a machine learning (ML) approach to further demonstrate their utility in predicting clinical outcomes. METHODS/STUDY POPULATION: We have …

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Intra-Subject Heterogeneity of Lesion SUV on [68GA]Dotatate PET/MRI in Patients with Multiple Meningiomas: Implications for Tumor Biology and Clinical Management

Se Jung Chang, Arsalan Haghdel, S. Kim, Michelle Roytman et autres

Purpose: Meningiomas are the most common primary intracranial neoplasms. While MRI remains the gold standard for the evaluation of meningiomas, it has significant limitations, including limited sensitivity and specificity for infiltrative or “en plaque” lesions, presence of osseous or parenchymal invasion, and …

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NIMG-91. DOTATATE PET/MR-GUIDED POSTOPERATIVE MANAGEMENT IN WHO-2 MENINGIOMA: ACTIVE SURVEILLANCE BASED ON PET/MR EVIDENCE OF GROSS TOTAL RESECTION

Jonathan Petrus Sandberg Knisely, Se Jung Chang, Sean Kim, Arsalan Haghdel et autres

Abstract BACKGROUND MRI, the standard of care (SOC) for meningioma radiotherapy planning, lacks sensitivity for postoperative small volume disease and osseous or parenchymal invasion. BN003 (NCT03180268) randomizes patients with WHO-2 meningiomas and MRI-determined GTR to observation or 60 Gy IMRT to the …

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NIMG-92. DOTATATE PET/MR-GUIDED POSTOPERATIVE RADIOTHERAPY IN SUBTOTALLY RESECTED WHO-2 MENINGIOMA: EVALUATION OF PROGRESSION-FREE SURVIVAL IN A PROSPECTIVE COHORT

Jonathan Petrus Sandberg Knisely, Se Jung Chang, Sean Kim, Arsalan Haghdel et autres

Abstract BACKGROUND Current postoperative management recommendations for meningioma lack Level 1 evidence. NRG-0539 (NCT00895622) treated recurrent WHO-1 and newly diagnosed and completely resected (by postoperative MRI) WHO-2 meningiomas with postoperative fractionated radiotherapy to 54 Gy, but 3 year PFS remained below 60%. …

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A Case of Multiple Splenic Lymph angiomas Diagnosed by Percutaneous Needle Biopsy

Seung Seog Ki, Sook‐Hyang Jeong, Chang Jin Yoon, Hye Seung Lee et autres

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