Albert Tran

Genetic variants and the risk of renal impairment in decompensated cirrhosis: a multi-ancestry genome-wide association study

Lukas Otero Sanchez, Joan Clãria, Clélia Galvanin, Ferrán Aguilar et autres

be, es, fr, de, cz, hu, br, it, ar, mx, gb, cl, sk, pe, ro (code pays fourni par la source)

Hepatocyte MLKL drives obesity-driven hepatocellular carcinoma progression via mitochondrial dysfunction independent of necroptosis in MASLD

Phoebe Ohene-Marfo, Sabira Mohammed, Chao Jiang, Shylesh Bhaskaran et autres

BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of HCC, particularly in obesity, yet mechanisms linking hepatocyte dysfunction to tumorigenesis remain unclear. Mixed lineage kinase domain-like protein (MLKL), the effector of necroptosis, is elevated in MASLD, but …

us (code pays fourni par la source)

A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran et autres

ABSTRACT Liver aging is characterized by chronic inflammation and metabolic dysfunction that contributes to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Necroptosis, a form of inflammatory cell death, is activated in aging livers, and genetic ( Ripk3 -/- or Mlkl …

us (code pays fourni par la source)

Volixibat zur Behandlung des cholestatischen Pruritus bei primär biliärer Cholangitis: Zwischenergebnisse der adaptiven, randomisierten, placebokontrollierten Phase-IIb-Studie (VANTAGE)

J Trebicka, Kris V. Kowdley, Mitchell L. Shiffman, D Weinstein et autres

Einleitung: Cholestatischer Pruritus (CP) ist ein belastendes Symptom der primären biliären Cholangitis (PBC), das die Lebensqualität stark beeinträchtigt. Erhöhte Serum-Gallensäuren (sBA) scheinen bei CP eine Rolle zu spielen. Volixibat (VLX) ist ein IBAT-Inhibitor, der die enterohepatische Rezirkulation von Gallensäuren unterbricht und zu …

de, us, il, it, gb, ph, fr (code pays fourni par la source)

CD44 in Group 1 Innate Lymphoid Cells Impacts the Development and Progression of Steatohepatitis

Manon Bourinet, E. G. J. Vieira, Déborah Rousseau, Stéphanie Bonnafous et autres

ABSTRACT Background and Aims Innate lymphoid cells (ILCs) play pivotal roles in inflammation and fibrosis, which are key features of chronic liver diseases. The contribution of group 1 ILCs, including natural killer (NK) cells and helper‐like ILC1s, to liver inflammation during steatohepatitis …

fr, de (code pays fourni par la source)

708. COMPARISON OF FEATURES OF RELAPSE RISK BETWEEN ALCOHOL-DEPENDENT INDIVIDUALS IN JAPAN AND AUSTRALIA THROUGH USE OF VALIDATED SELF-RATING SCALE: THE ALCOHOL RELAPSE RISK SCALE

Shaowei Lu, Albert Tran, Donat N. Dutkiewicz, Peter McCaul et autres

Abstract Background Alcohol use disorder (AUD) is a prevalent, chronic condition with potential serious consequences. The Alcohol Relapse Risk Scale (ARRS) is a multi-dimensional, 32-item self-reported scale developed in Japan which has shown correlation in the clinical setting to predict alcohol relapse. …

au (code pays fourni par la source)

407. COMPARISON OF FEATURES OF RELAPSE RISK BETWEEN ALCOHOL-DEPENDENT INDIVIDUALS IN JAPAN AND AUSTRALIA THROUGH USE OF VALIDATED SELF-RATING SCALE: THE ALCOHOL RELAPSE RISK SCALE

Shaowei Lu, Kaniz Fatema, Albert Tran, Donat N. Dutkiewicz et autres

Abstract Background Alcohol use disorder (AUD) is a prevalent, chronic condition with potential serious consequences. The Alcohol Relapse Risk Scale (ARRS) is a multi-dimensional, 32-item self-reported scale developed in Japan which has shown correlation in the clinical setting to predict alcohol relapse. …

au (code pays fourni par la source)

Incretins and MASLD: at the Crossroads of Endocrine and Hepatic Disorders

Marwin A. Farrugia, Albert Tran, Nicolas Chevalier, Rodolphe Anty et autres

PURPOSE OF REVIEW: The aim of this paper is to provide an overview of metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis, focusing on how incretin analogues might affect liver function and disease. It also summarizes the latest preclinical studies and clinical trials …

fr (code pays fourni par la source)

Value of non-invasive test dynamics in guiding HCC surveillance decisions after HCV cure in patients with cirrhosis

Pierre Nahon, Clovis Lusivika‐Nzinga, Philippe Merle, Fabien Zoulim et autres

fr, us, gp (code pays fourni par la source)

Impact of Mlkl or Ripk3 deletion on age-associated liver inflammation, metabolic health, and lifespan

Sabira Mohammed, Phoebe Ohene-Marfo, Chao Yun Jiang, Zongkai Peng et autres

Abstract Chronic, low-grade inflammation is a hallmark of aging and various age-related diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). The prevalence of metabolic dysfunction-associated steatohepatitis (MASH), an advanced form of MASLD, increases with age and contributes to morbidity and mortality among …

us (code pays fourni par la source)

596 Bridging the gap: combined adult and pediatric hematology/oncology fellowship seminars (caps) to enhance interdisciplinary collaboration

Albert Tran, Paige V. Strebeck, Deborah Wilson, Tyler Fugere et autres

CD44 in myEloid cells is a major driver of liver inflammation and injury in alcohol-related liver disease

Déborah Rousseau, Stéphanie Bonnafous, Frédéric Soysouvanh, Dorian Sarrail et autres

BACKGROUND AND AIMS: Alcohol-associated liver disease (ALD) is one of the leading causes of severe liver disease with limited pharmacological treatments for alcohol-associated steatohepatitis. CD44, a glycoprotein mainly expressed in immune cells, has been implicated in multiple inflammatory diseases but has never …

fr, de, us (code pays fourni par la source)