‎Maria Twomey

Prospective evaluation of the breast microbiome and tumor microenvironment-related biomarkers of response to neoadjuvant systemic therapy in triple negative breast cancer.

Maeve Hennessy, Emilene S Morais, Ciarán Devoy, G. L. Walsh et autres

TPS615 Background: Predictive biomarkers of response to combination chemotherapy and immune-checkpoint inhibitors are urgently needed to tailor treatment recommendations for patients with early-stage triple negative breast cancer (eTNBC). Our group has demonstrated that tumour-associated microbiota in primary breast tumours represent promising and …

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Dealing with digital paralysis: Surviving a cyberattack in a National Cancer center

Rachel J. Keogh, Harry Myles Harvey, Claire Brady, Edel Hassett et autres

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1730P Dealing with digital paralysis: Surviving a cyberattack in a cancer centre

Rachel J. Keogh, Harry Myles Harvey, Claire Brady, Edel Hassett et autres

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Primary Small Cell Carcinoma of the Breast: When a Rare Tumour is Real

Ruba Hamed, Rachel J. Keogh, Abdullah Ali Mohammed, ‎Maria Twomey et autres

Background: Extra-pulmonary small-cell neoplasms are rare, and treatment planning is challenging for clinicians. The lack of guideline-based management undermines and isolates patients for whom these cancers are not just rare but also real. Small-cell breast cancer (SCBC) is a rare, aggressive disease …

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Body Composition, Inflammation, and 5-Year Outcomes in Colon Cancer

Christina Fleming, Emer O’Connell, Richard G. Kavanagh, Donal Peter O’Leary et autres

Importance: Obesity, particularly visceral obesity and sarcopenia, are poor prognostic indicators in colon cancer. Objectives: To explore the association between body composition profiles and 5-year colon cancer outcomes and delineate the associated underlying inflammatory processes. Design, Setting, and Participants: This multicenter translational …

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A comparison of embalming fluids on the structures and properties of tissue in human cadavers

Joy Y. Balta, ‎Maria Twomey, Fiachra Moloney, Orla Duggan et autres

Abstract Cadaveric material has long been used to teach anatomy and more recently to train students in clinical skills. The aim of this study was to develop a systematic approach to compare the impact of four embalming solutions on the tissues of …

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Low-dose CT imaging of the acute abdomen using model-based iterative reconstruction: a prospective study

Fiachra Moloney, Karl James, ‎Maria Twomey, David John Ryan et autres

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A phantom study of the performance of model-based iterative reconstruction in low-dose chest and abdominal CT: When are benefits maximized?

Fiachra Moloney, ‎Maria Twomey, Kirstyn James, Richard G. Kavanagh et autres

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Assessment of isocenter alignment during CT colonography: Implications for clinical practice

Karen Olden, Richard G. Kavanagh, Kirstyn James, ‎Maria Twomey et autres

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Determination of a suitable low‐dose abdominopelvic CT protocol using model‐based iterative reconstruction through cadaveric study

Fiachra Moloney, ‎Maria Twomey, Daniel Fama, Joy Y. Balta et autres

INTRODUCTION: Cadaveric studies provide a means of safely assessing new technologies and optimizing scanning prior to clinical validation. Reducing radiation exposure in a clinical setting can entail incremental dose reductions to avoid missing important clinical findings. The use of cadavers allows assessment …

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Sarcopenia and Post-Operative Morbidity and Mortality in Patients with Gastric Cancer

‎Maria Twomey, Fiachra Moloney, Richard G. Kavanagh, Brian W. Carey et autres

PURPOSE: Surgical resection for gastric adenocarcinoma is associated with significant post-operative morbidity and mortality. The aim of this study was to assess the prognostic significance of sarcopenia in patients undergoing resection for gastric adenocarcinoma with respect to post-operative morbidity and survival. MATERIALS …

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The Small Bowel: An Imaging Guide

‎Maria Twomey, Fiachra Moloney, Karl James, Jennifer Sammon et autres

Background: This article reviews the latest radiological advances in the evaluation of small bowel disease. MRI and CT have been optimized in recent years for small bowel imaging including the development of enteric agents to distend the bowel, multiplanar thin-section imaging, advanced …

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