Savanna Smith

Sex differences in renal mitochondrial respiration and renal function in adult intrauterine growth restricted rodents with MitoTEMPO treatment

Savanna Smith, Jonna Smith, Jameon Love, Emily Chastain et autres

Introduction: Intrauterine growth restriction (IUGR) affects 5-8% of pregnancies worldwide. IUGR increases the risk for kidney disease later in life, especially in males. One mechanism that may contribute to these sex differences is mitochondrial dysfunction. Mitochondrial dysfunction leads to oxidative stress accumulation, …

us (code pays fourni par la source)

Sex differences in cardiac anti-inflammatory cytokines in adult intrauterine growth restricted rodents

Jisu Kim, Savanna Smith, Jonna Smith, Vyshnavi Pottepalli et autres

Background: Approximately 5-10% of U.S. pregnancies are affected by intrauterine growth restriction (IUGR), which is often due to placental ischemia. Adults who were exposed to IUGR have a higher risk of developing cardiovascular diseases (CVD), in which there are sex differences where …

us (code pays fourni par la source)

Exploring The Use Of Machine Learning To Connect Microbial Community Assembly Processes To Water Resource Recovery Facility Performance

Savanna Smith, francis de los reyes

Sex Differences in Blood Pressure and Renal Nitric Oxide Bioavailability, Oxidative Stress, and Inflammation in Rodents Exposed to a Low Resource Environment

Angie Castillo, Jonna Smith, Savanna Smith, Kylie Jones et autres

Background: Adverse childhood experiences (ACEs) are traumatic events, such as poverty, that occur before the age of 18. ACEs affect ~60% of all adults in the United States and is a major risk factor for the development of hypertension (HTN). Multiple clinical …

us (code pays fourni par la source)

Cerebral Inflammation and Sex Differences in Young Rodents Exposed to a Low Resourced Environment May Predict the Onset of Hypertension in Adulthood

Jonna Smith, Savanna Smith, Angie Castillo, Kylie Jones et autres

Introduction: Adverse Childhood Experiences (ACEs) are associated with negative health outcomes as children progress to adults. Poverty, a type of ACE, impacts 16 million children annually in the USA. Childhood poverty is associated with hypertension (HTN) and increased inflammation in adulthood. To …

us (code pays fourni par la source)

Placental ischemia during pregnancy induces hypertension, cerebral inflammation, and oxidative stress in dams postpartum

Savanna Smith, Jonna Smith, Kylie Jones, Angie Castillo et autres

BACKGROUND: Preeclampsia (PE) is characterized as de novo hypertension (HTN) with end-organ damage, especially in the brain. PE is hypothesized to be caused by placental ischemia. PE affects ~5-8% of USA pregnancies and increases the risk for HTN and cerebrovascular diseases (CVD) …

us (code pays fourni par la source)

Intrauterine growth‐restricted pregnant rats, from placental ischemic dams, display preeclamptic‐like symptoms: A new rat model of preeclampsia

Jonna Smith, Madison Powell, Whitney Cromartie, Savanna Smith et autres

Preeclampsia (PE) is characterized by de novo hypertension (HTN) and is often associated with intrauterine growth restriction (IUGR). Hallmarks of PE are placental ischemia, decreased nitric oxide (NO) bioavailability, oxidative stress (OS), and organ damage in the kidneys and brain. This study …

us (code pays fourni par la source)

Renal Oxidative Stress May Explain Sex Differences in Blood Pressure in Adult Offspring Exposed to an Impoverished Environment

Angie Castillo, Savanna Smith, Kylie Jones, Jonna Smith et autres

Background: Nearly 40 million people experience poverty in the United States. Poverty is linked to adverse childhood experiences (ACEs) which affects about 64% of adults in the U.S. Previous studies indicate that those who experience ACEs are at a higher risk of …

us (code pays fourni par la source)

Changes in Cerebral Mitochondrial Function in Postpartum Dams Exposed to a Low-resource Environment during Weaning

Kylie Jones, Savanna Smith, Angie Castillo, Jonna Smith et autres

Background. Postpartum depression is a serious mental-health condition, affecting over 14% of all mothers in the U.S. Poverty, a lack of educational and economic resources, is a major determinant of adult mental health. Within the U.S., poverty impacts 11% of adults, with …

us (code pays fourni par la source)

Elevated Renal Oxidative Stress and Na+ Transporters are Associated with Hypertension in Postpartum Preeclamptic Rats

Savanna Smith, Angie Castillo, Kylie Jones, Jonna Smith et autres

Background: Approximately 5-10% of US pregnancies result in preeclampsia (PE). PE is characterized by new onset hypertension (HTN) during pregnancy and is usually accompanied by end-organ damage, especially in the kidneys. Postpartum (PP) women and dams that had PE have an increased …

us (code pays fourni par la source)

Intrauterine Growth-Restricted Pregnant Rats, from Hypertensive Placental Ischemic Dams Display Preeclamptic-like Symptoms: A New Rodent Model of Preeclampsia

Jonna Smith, Madison Powell, Whitney Cromartie, Savanna Smith et autres

ABSTRACT Preeclampsia (PE) is characterized by de novo hypertension (HTN) and is one of the primary causes of intrauterine growth restriction (IUGR). PE is associated with placental ischemia, decreased nitric oxide (NO) bioavailability, oxidative stress (OS), and organ damage in the kidneys …

us (code pays fourni par la source)

Abstract P210: Sex Specific Changes In Cerebral Proinflammatory Cytokines In Intrauterine Growth Restricted Offspring

Savanna Smith, Jonna Smith, Kylie Jones, Angie Castillo et autres

Background: Intrauterine growth restriction (IUGR) often times results from placental ischemia, which restricts the distribution of nutrients and oxygen to meet the metabolic demand of the growing fetus. IUGR offspring (OS) have an increased risk for developing cerebrovascular diseases (CVD) later in …

us (code pays fourni par la source)