Nazli Kuter

Intranasal therapies for neonatal hypoxic-ischemic encephalopathy

Andrew S. Cavanagh, Benjamin I. Sollinger, Nazli Kuter, Khyzer B. Aziz et autres

Neonatal hypoxic-ischemic encephalopathy is the leading cause of brain injury in term infants worldwide and disproportionately affects low- and middle-income communities. Therapeutic hypothermia, the standard of care for hypoxic-ischemic encephalopathy in high-resourced settings, has no effect on morbidity and increases mortality after …

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Vitamin C for neuroprotection in neonatal encephalopathy

Raul Chavez‐Valdez, Nazli Kuter, Srishti Jayakumar

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Intranasal therapies for neonatal hypoxic-ischemic encephalopathy: Systematic review, synthesis, and implications for global accessibility to care

Andrew S. Cavanagh, Nazli Kuter, Benjamin I. Sollinger, Khyzer B. Aziz et autres

Neonatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of neurodevelopmental morbidity in term infants worldwide. Incidence of HIE is highest in low and middle-income communities with minimal access to neonatal intensive care and an underdeveloped infrastructure for advanced neurologic interventions. Moreover, therapeutic …

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Neocortical cholinergic pathology after neonatal brain injury is increased by Alzheimer's disease-related genes in mice

Leslie Doucette, Victoria Turnbill, Katherine Carlin, Andrew S. Cavanagh et autres

Hypoxic-ischemic encephalopathy (HIE) in neonates causes mortality and neurologic morbidity, including poor cognition with a complex neuropathology. Injury to the cholinergic basal forebrain and its rich innervation of cerebral cortex may also drive cognitive pathology. It is uncertain whether genes associated with …

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Proceedings of the 14 th International Newborn Brain Conference: Neuroprotection strategies in the neonate

Shalima Abdurajan, Johan Ågren, Jesse Alt, Anna Axelin et autres

BACKGROUND AND PURPOSE:Human Breast milk is universally recognized as the best-adapted food for infants and toddlers.Although the chemical composition of breast milk has been extensively studied, recent evidence, describe the presence of a cellular subpopulation having stem cell properties.Neonatal cerebral lesions resulting …

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Newborn Weight Loss Tool and Readmission for Hyperbilirubinemia

David L. Schutzman, Nazli Kuter, Agnes Salvador, Dorothy E Wyatt et autres

OBJECTIVE: The aim of this study was to determine if the Newborn Weight Loss Tool (NEWT) can predict hospital readmission due to hyperbilirubinemia. STUDY DESIGN: This is a case-control study of 93 newborns and 186 controls ≥35 weeks' gestation. All were discharged …

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The Neuroprotective Effects of Hypothermia on Bilirubin-Induced Neurotoxicity in vitro

Nazli Kuter, Neşe Ayşit-Altuncu, Gürkan Öztürk, Eren Özek

BACKGROUND: In high-risk newborns indirect hyperbilirubinemia can lead to acute bilirubin encephalopathy and kernicterus. Despite the current therapeutic modalities, preventing or reversing the neurotoxicity cannot be achieved in all infants. OBJECTIVE: To investigate the neuroprotective effects of hypothermia on bilirubin-induced toxicity in …

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Supplementary Material for: The Neuroprotective Effects of Hypothermia on Bilirubin-Induced Neurotoxicity in vitro

Nazli Kuter, Neşe Ayşit-Altuncu, Gürkan Öztürk, Eren Özek

Background: In high-risk newborns indirect hyperbilirubinemia can lead to acute bilirubin encephalopathy and kernicterus. Despite the current therapeutic modalities, preventing or reversing the neurotoxicity cannot be achieved in all infants. Objective: To investigate the neuroprotective effects of hypothermia on bilirubin-induced toxicity in …

A Case of Multiple Gastrointestinal Obstructions in a Newborn Presenting With Pseudo-Bartter’s Syndrome

Zeynep Alp Ünkar, Nazli Kuter, Kıvılcım Karadeniz Cerit, Asli Cinar Memisoglu et autres

Hypochloremic metabolic alkalosis occurs in pseudo-Bartte ’s syndrome (PBS) without a primary renal tubular defect. Usually seen in cystic fibrosis, this syndrome can also be caused by recurrent vomiting for various reasons. We present a case of multiple gastrointestinal anomalies, each by …

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