Zoe E. Reed

Modelling learning trajectories of facial emotion recognition training in autistic children

Osama Mahmoud, Dejla Hoxha, Ian S. Penton‐Voak, Christopher Jarrold et autres

Abstract Background Emotion recognition (ER) skills are important in social interaction. ER difficulties are associated with social difficulties and may lead to poorer educational outcomes and wellbeing. There is therefore considerable interest in tools that support development of ER skills. In addition, …

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599 Baseline body composition and sarcopenia measures of adults with preserved lung function in the STRONG-CF Study

Hélder Fonseca, Zoe E. Reed, Juan G. Álvarez, S. Freedman et autres

Accounting for place: confounding via geography obscures polygenic evidence on mental health and environmental exposures in the UK Biobank

Zoe E. Reed, Tim Morris, Oliver S. P. Davis, George Davey Smith et autres

Abstract Clustering of common causes by geography (confounding via geography) can induce bias if ignored. Analyses using polygenic indicators (PGI) for mental health traits are traditionally adjusted for genetic principal components (PCs), but not local area. In this study, we investigate whether …

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Assessing the effectiveness of multi-session online emotion recognition training in autistic adults

Zoe E. Reed, Oliver Bastiani, Andy Eastwood, Ian S. Penton‐Voak et autres

Difficulties with emotion recognition can occur in neurodevelopmental conditions, including in autistic individuals. Providing interventions to support this would therefore be beneficial, particularly in terms of downstream effects on wellbeing, social relationships and education. In this online experimental study, we examined the …

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Maternal cannabis use in pregnancy, perinatal outcomes, and cognitive development in offspring: a longitudinal analysis of the ALSPAC cohort using paternal cannabis use as a negative control exposure

Daniel J. Corsi, Tim Morris, Zoe E. Reed, George Davey Smith

Maternal cannabis use in pregnancy is reported to be associated with perinatal and neurodevelopmental outcomes in offspring. Such associations, however, may be biased by residual confounding by socioeconomic position (SEP). To assess confounding, we use paternal cannabis use in pregnancy as a …

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Investigating whether smoking and alcohol behaviours influence risk of type 2 diabetes using a Mendelian randomisation study

Zoe E. Reed, Hannah Sallis, Rebecca C. Richmond, Angela S. Attwood et autres

Previous studies suggest that smoking and higher alcohol consumption are associated with greater type 2 diabetes (T2D) risk. However, studies examining whether this reflects causal relationships are limited and often do not consider continuous glycaemic traits. We conducted both two-sample and one-sample …

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Triangulated evidence provides no support for bidirectional causal pathways between diet/physical activity and depression/anxiety

Kirsten J. M. van Hooijdonk, Zoe E. Reed, Nina van den Broek, Madhurbain Singh et autres

Abstract Background Previous studies (various designs) present contradicting insights on the potential causal effects of diet/physical activity on depression/anxiety (and vice versa). To clarify this, we employed a triangulation framework including three methods with unique strengths/limitations/potential biases to examine possible bidirectional causal …

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Investigating causal relationships between loneliness, social isolation and health

Darren D Hilliard, Robyn E. Wootton, Hannah Sallis, Margot P. van de Weijer et autres

Abstract Loneliness and social isolation are important public health concerns due to their associations with a range of health outcomes. However, it is difficult to ascertain whether loneliness and social isolation cause those outcomes or whether the observed associations are biased by …

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635 Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF (STRONG-CF): a study protocol

Juan G. Álvarez, Melissa S. Putman, Alexandra Stein, Judy Sibayan et autres

Mapping associations of polygenic scores with autistic and ADHD traits in a single city region

Zoe E. Reed, Richard Thomas, Andy Boyd, Gareth J Griffith et autres

BACKGROUND: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants? METHODS: We mapped associations between polygenic scores for …

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Exploring pleiotropy in Mendelian randomisation analyses: What are genetic variants associated with ‘cigarette smoking initiation’ really capturing?

Zoe E. Reed, Robyn E. Wootton, Jasmine Khouja, Tom G. Richardson et autres

Genetic variants used as instruments for exposures in Mendelian randomisation (MR) analyses may have horizontal pleiotropic effects (i.e., influence outcomes via pathways other than through the exposure), which can undermine the validity of results. We examined the extent of this using smoking …

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Do smoking and alcohol behaviours influence risk of type 2 diabetes? A Mendelian randomisation study

Zoe E. Reed, Hannah Sallis, Rebecca C. Richmond, Angela S. Attwood et autres

Abstract Background Previous studies suggest that smoking and higher alcohol consumption are both associated with greater risk of type 2 diabetes (T2D). However, studies examining whether these associations reflect causal relationships are limited and do not consider continuous glycaemic traits. The aim …

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