Henrik Holbech

Adverse outcome pathway network-based approach for the evaluation of thyroid hormone system disruption for human health and environmental regulatory hazard assessment

Lucia Vergauwen, Sabrina Tait, Lola Bajard, Natalia Buławska et autres

Thyroid hormones (THs) are essential for growth, development, and metabolism across vertebrates. Thyroid hormone system disruption (THSD), as one of the mechanisms of endocrine disruption (ED), is widely recognised as a critical concern for both human and environmental health. Important challenges remain …

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Charge Matters, but So Does Species: Amphibian Early Development under Exposure to Clean Dialyzed Nanoplastics

Mohamed Helal, Jakub Sedzinski, Xiaoyu Duan, Shan Wang et autres

Nanoplastics (NPs) are emerging aquatic contaminants, yet their impacts on amphibians remain poorly resolved despite their ecological relevance and developmental sensitivity. We assessed developmental, behavioral, and transcriptomic responses in early life-stage Xenopus laevis exposed to clean, dialyzed polystyrene NPs bearing negative carboxyl …

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Effects of bisphenol E on thyroid hormone system and developmental neurotoxicity-sensitive endpoints in zebrafish embryos – a new approach methodologies-based evaluation

Pernille Ambus Kjær, Simone Fibiger Sørensen, Amanda Theresa Jane Lee, Katrine Clement Kirkegaard et autres

Endocrine-disrupting chemicals (EDCs), including some bisphenols, are of increasing concern. Aligned with the 3Rs (Reduction, Replacement, Refinement of animal experiments) and the EU's roadmap to phase out animal testing, zebrafish eleutheroembryos are key in developing New Approach Methodologies (NAMs) as they are …

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AOP report: Adverse outcome pathway network for developmental androgen signaling inhibition leading to hypospadias

Emilie Elmelund, Monica Kam Draskau, Henrik Holbech, Terje Svingen

This report summarizes an adverse outcome pathway network (AOPN) describing how reduced androgen signaling during fetal life may lead to hypospadias in male offspring. Hypospadias is a penile malformation caused by disrupted masculinization of the genital tubercle. Under normal physiological conditions, androgen …

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Structured overview of thyroid hormone system disruption mechanisms, effects, and associated assays as a resource for the development of integrated approaches for testing and assessment

Lola Bajard, Ellen V.S. Hessel, Sabrina Tait, Natalia Buławska et autres

This work provides an in-depth overview of the main mechanisms and effects related to thyroid hormone system disruption (THSD). Table 1 and accompanying text include, among others, the methods and supporting mechanistic information (mainly adverse outcome pathways (AOPs)) currently available, as well …

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Structured overview of thyroid hormone system disruption mechanisms, effects, and associated assays as a resource for the development of integrated approaches for testing and assessment

Lola Bajard, Ellen V.S. Hessel, Sabrina Tait, Natalia Buławska et autres

This work provides an in-depth overview of the main mechanisms and effects related to thyroid hormone system disruption (THSD). Table 1 and accompanying text include, among others, the methods and supporting mechanistic information (mainly adverse outcome pathways (AOPs)) currently available, as well …

cz, nl, it, pl, lu, dk, gr, be, gb (code pays fourni par la source)

Zebrafish neuromast development: a target for endocrine disrupting chemicals?

Ellen Vandeputte, Evelyn Stinckens, Jade Verreth, Simone Fibiger Sørensen et autres

In response to increasing evidence of human and environmental health impacts of endocrine disrupting chemicals (EDCs), screening and testing programs for EDC assessment are being developed, requiring characterization of potential adverse health effects. The development of the lateral line (LL), a neurosensory …

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New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption – a PARC project

Jacob Ardenkjær-Skinnerup, Yoni Baert, Lola Bajard, Jonathan H. Blum et autres

Endocrine disruptors (EDs) are implicated in adverse developmental and reproductive outcomes, yet their identification remains a major challenge in chemical safety assessment. Current testing strategies rely heavily on animal models, which are constrained by ethical concerns, interspecies differences, and limited mechanistic resolution …

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Global framework for communication of biological invasion risks

Lorenzo Vilizzi, Vettath Suresh, Daniela Giannetto, Jeffrey Hill et autres

Biological invasions, driven by the spread of non-native species, have become a critical global issue because of their far-reaching ecological and socioeconomic impacts. Effective communication of the risks of biological invasions is essential for implementing robust policy and legislation and gaining public …

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Global framework for communication of biological invasion risks

Lorenzo Vilizzi, V V R Suresh, Daniela Giannetto, Jeffrey E. Hill et autres

Biological invasions, driven by the spread of non-native species, have become a critical global issue because of their far-reaching ecological and socioeconomic impacts. Effective communication of the risks of biological invasions is essential for implementing robust policy and legislation and gaining public …

The assessment for potential thyroid‐mediated endocrine disruption in amphibians: Clarification on the use of new methods and on the interpretation of changes in thyroid histology

Lisa Baumann, Alice Baynes, Susanne Hougaard Bennekou, Kevin M. Crofton et autres

) are used as the model species to assess potential endocrine-disrupting properties in non-mammalian species through thyroid modality. The amphibian metamorphosis assay is the most frequently available test. Attempts have been made to modify this protocol in order to make it more …

Toxicity of bisphenol A alternatives: A study on bisphenol E in two generations of the freshwater snail Lymnaea stagnalis

Gaëtan Y. Tucoo, Jane Ebsen Morthorst, Elvis Genbo Xu, Henrik Holbech

Bisphenol E (BPE), a substitute for bisphenol A (BPA), is becoming increasingly prevalent in the market and, consequently, the environment. Yet, the effects of such alternatives on aquatic organisms remain largely unknown. This study focuses on assessing the developmental toxicity of BPE …

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