M. Reza Jabalameli

Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health

Hayley H. A. Thorpe, Renata B. Cupertino, Shreya R. Pakala, Pierre Fontanillas et autres

Abstract Delay discounting (DD), a person’s preference for smaller immediate rewards over larger delayed rewards, is a heritable trait that is associated with psychiatric and physical outcomes, yet the biological mechanisms underlying these links are not known. We performed a GWAS of …

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Association between polygenic risk and survival in breast cancer patients

Danielle E. Kurant, Stefan Groha, Yi Ding, Chris German et autres

BACKGROUND: Polygenic risk scores (PRS) estimate an individual’s germline genetic predisposition to a quantitative trait and/or risk of disease. Several PRS have been developed for cancer risk with the goal of improved risk screening. Here, we sought to establish whether PRS for …

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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy

M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang et autres

The highly polygenic nature of human longevity renders pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between aging-related traits (ARTs), we aimed to model the additive variance in lifespan as a function of the cumulative liability from pleiotropic …

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Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases

Jhih-Rong Lin, Patrick Sin‐Chan, Valerio Napolioni, Guillermo G. Torres et autres

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Analysis of 3.6 million individuals yields minimal evidence of pairwise genetic interactions for height

M. Reza Jabalameli, Michael V. Holmes, David A. Hinds, Adam Auton et autres

Abstract Adult height is a highly heritable polygenic trait with heritability attributable to thousands of independent variants. Large-scale studies have been able to detect genetic variants with contributions to height in the range of approximately 1.2 millimetre per allele copy on average. …

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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy

M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang et autres

ABSTRACT The highly polygenic nature of human longevity renders cross-trait pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between the aging-related traits (ARTs), we sought to model the additive variance in lifespan as a function of cumulative liability …

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The role of interferon-gamma and its receptors in gastrointestinal cancers

Zahra Mozooni, Nafiseh Golestani, Leyla Bahadorizadeh, Reyhaneh Yarmohammadi et autres

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Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia

Jhih-Rong Lin, Yingjie Zhao, M. Reza Jabalameli, Nha Nguyen et autres

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Substance abuse and the risk of severe COVID-19: Mendelian randomization confirms the causal role of opioids but hints a negative causal effect for cannabinoids

M. Reza Jabalameli, Zhengdong D. Zhang

Since the start of the COVID-19 global pandemic, our understanding of the underlying disease mechanism and factors associated with the disease severity has dramatically increased. A recent study investigated the relationship between substance use disorders (SUD) and the risk of severe COVID-19 …

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Substance abuse and the risk of severe COVID-19: Mendelian randomization confirms the causal role of opioids but hints a negative causal effect for cannabinoids

M. Reza Jabalameli, Zhengdong D. Zhang

Abstract Since the start of the COVID-19 global pandemic, our understanding of the underlying disease mechanism and factors associated with the disease severity has dramatically increased. A recent report investigated the relationship between substance use disorders (SUD) and the risk of severe …

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Unravelling genetic components of longevity

M. Reza Jabalameli, Zhengdong D. Zhang

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Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation

Quanwei Zhang, Gregory Tombline, Julia Ablaeva, Lei Zhang et autres

The North American beaver is an exceptionally long-lived and cancer-resistant rodent species. Here, we report the evolutionary changes in its gene coding sequences, copy numbers, and expression. We identify changes that likely increase its ability to detoxify aldehydes, enhance tumor suppression and …

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