John W. Winkelman

Consensus Roadmap on Periodic Leg Movements during Sleep (PLMS): Outcomes of the International PLMS Taskforce.

Stephany Fulda, Mathias Baumert, Matteo Cesari, Stefan Clemens et autres

Periodic leg movements during sleep (PLMS) are a frequently observed motor phenomena in polysomnography, yet their biological meaning and clinical relevance are debated. Further, how these should be evaluated and tabulated for optimal evaluation is uncertain. To address these gaps, an international, …

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Neurostimulation for restless legs syndrome: A systematic review and meta-analysis

Cornelius G. Bachmann, Giuseppe Lanza, Gulcin Benbir Şenel, Lourdes M. DelRosso et autres

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Consensus roadmap on periodic leg movements during sleep: outcomes of the international PLMS taskforce

Stephany Fulda, Mathias Baumert, Matteo Cesari, Stefan Clemens et autres

Periodic leg movements during sleep (PLMS) are a frequently observed motor phenomenon in polysomnography, yet their biological meaning and clinical relevance are debated. Further, how these should be assessed and tabulated for optimal evaluation is uncertain. To address these gaps, an international, …

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Restless Legs Syndrome: A Review.

John W. Winkelman, Benjamin Wipper

Importance: Restless legs syndrome (RLS) is a sleep-related movement disorder that affects approximately 3% of US adults to a clinically significant extent and can cause substantial sleep disturbance. Observations: Restless legs syndrome is characterized by an overwhelming urge to move the limbs, …

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Pharmacologic treatment data from chronic insomnia studies and the application to individuals with acute insomnia, a narrative review

Andrew Krystal, Ruth M. Benca, W. Vaughn McCall, Michael L. Perlis et autres

A variety of pharmacologic treatments are approved for insomnia, encompassing a range of mechanisms of action, including some treatments with published data in models of acute insomnia. However, most studies are conducted in individuals with chronic insomnia. Thus, it is unclear whether …

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Restless Legs Syndrome

John W. Winkelman

Importance Restless legs syndrome (RLS) is a sleep-related movement disorder that affects approximately 3% of US adults to a clinically significant extent and can cause substantial sleep disturbance. Observations Restless legs syndrome is characterized by an overwhelming urge to move the limbs, …

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Effectiveness and dose stability of opioids in patients with restless leg syndrome: 5-year findings from the National Restless Legs Syndrome Opioid Registry

John W. Winkelman, Adysn Kilty, Benjamin Wipper, Jordana Zackon et autres

STUDY OBJECTIVES: Large long-term assessments of opioid effectiveness and dose stability for those with dopamine agonist augmentation of restless legs syndrome (RLS) are lacking. We present 5-year longitudinal findings from the National RLS Opioid Registry. METHODS: Five-hundred participants taking opioids for RLS …

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From Normal Variation in Sleep to Clinical Sleep Disorders: Genetic Insights from Over One Million Individuals

Lovemore Kunorozva, Jesse Valliere, Chia‐Yen Chen, Matthew Maher et autres

Sleep disorders affect over 30% of the U.S population and are linked to increased disease risk and mortality. However, the genetic architecture of sleep disorders and the overlap of sleep disorders with habitual sleep quality, quantity, and timing have been poorly characterized. …

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Transformer Model Detects Antidepressant Use From a Single Night of Sleep, Unlocking an Adherence Biomarker

Ali Mirzazadeh, Simon Cadavid, Kaiwen Zha, Chao Li et autres

Antidepressant nonadherence is pervasive, driving relapse, hospitalization, suicide risk, and billions in avoidable costs. Clinicians need tools that detect adherence lapses promptly, yet current methods are either invasive (serum assays, neuroimaging) or proxy-based and inaccurate (pill counts, pharmacy refills). We present the …

Sleep Related Movement Disorders: What's New and Changing Clinical Practice

Ambra Stefani, Qi Tang, Stefan Clemens, Lourdes M. DelRosso et autres

Restless legs syndrome (RLS) is a common sensorimotor disorder, and the most common sleep-related movement disorder with a prevalence of up to 15% in the European and US population. This review addresses key aspects of RLS, focusing on novel data that have …

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Respiratory-related leg movement as a predictor of mortality: the Osteoporotic Fractures in Men Sleep Study

Neda Esmaeili, Sayaka Aritake, Susan Redline, John W. Winkelman et autres

STUDY OBJECTIVES: Respiratory event-related leg movements (RRLMs) in obstructive sleep apnea may reflect event severity and predict adverse outcomes. This study examines the association between RRLM frequency and mortality. METHODS: A sample of 571 men (median [IQR] age: 76.0 [72.0-81.0] years; BMI: …

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0904 Five-Year Outcomes from the National RLS Opioid Registry: Efficacy, Stability, and Tolerability

John W. Winkelman, Adysn Kilty, Benjamin Wipper, Jordana Zackon

Abstract Introduction Opioids are effective in treating refractory or augmented restless legs syndrome (RLS) yet concerns about their long-term use in RLS are common. To investigate these concerns, the National RLS Opioid Registry tracks the long-term efficacy, dose stability, and tolerability of …

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