Wenting Li

IFIT3 promotes lymph node metastasis by interacting with LASP1 to activate FAK-ERK signaling in esophageal squamous cell carcinoma

Qixiao Cui, Xiaolin Zhou, Xiaojie Chen, Xiaochuan Zhao et autres

Lymph node metastasis (LNM) is an important cause of poor prognosis in patients with esophageal squamous cell carcinoma (ESCC). However, the mechanism of LNM in ESCC has not been elucidated. Here, we identified interferon-induced proteins with tetratricopeptide repeats 3 (IFIT3) highly expressed …

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Non-antibiotic nanoplatform based CuS/AuNCs@Lip NPs for inhibition pneumonia caused by MRSA and its mechanism exploration

Qing Fan, Xinzhong Zhang, Sai Zhang, Lingyu Zhang et autres

Methicillin-resistant Staphylococcus aureus (MRSA) is a major threat to human health due to its multi-antibiotic resistance, either intrinsic or acquired. One of the acquired mechanisms lies in MRSA biofilms, which shield bacteria from antibiotic eradication, contributing to chronic infections. To address this …

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Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells： Mediated Restoration of Endometrial Receptivity and Their Potential to Improve IVF–ET Outcomes

Wenting Li, X. Ge, Siqi Guo, Meijuan Liu

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The mechanism of astaxanthin in ameliorating primary sclerosing cholangitis-related liver-gut dysregulation in mice

Mengyao Wang, Ge Yu, Feng Zhang, Shengyuan Lu et autres

Primary sclerosing cholangitis (PSC) is a chronic cholestatic disorder primarily resulting from various etiologies that impair bile acids production, secretion and excretion. This impairment leads to the accumulation of toxic bile acids in the liver, causing bile duct obstruction and ultimately resulting …

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Exploring the application value of ultrasound in animal studies of stem cell therapy for intrauterine adhesions

Siqi Guo, Wenting Li, Xiaoran Chen, Meijuan Liu

Endometrial damage leads to intrauterine adhesions (IUA), significantly impairing endometrial receptivity and fertility. Stem cell therapies, particularly umbilical cord mesenchymal stem cell (UC-MSCs), have shown promise in regenerating damaged endometrium, but prior studies have relied on ex vivo pathological evaluations. Ultrasound, as …

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Efficacy Evaluation and Mechanism Study of Nonantibiotic Nanoplatform for Clearing MRSA

Xiangjun Chen, Xinzhong Zhang, Qing Fan, Sai Zhang et autres

The effective treatment of infections induced by biofilms has remained a substantial challenge in clinical practice. Presently, there is an imperative demand for innovative antimicrobial strategies that can not only eliminate biofilms but also incorporate controlled delivery and intelligent release mechanisms. In …

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Delivery of Dexamethasone Using Folate-Targeted Au Nanoflowers for Rheumatoid Arthritis Therapy

Keke Li, Tiantian Chen, Weiwei Li, X Zhang et autres

Rheumatoid arthritis (RA) is a prevalent chronic autoimmune disorder characterized by joint pain and progressive damage that can severely impair daily activities and reduce overall quality of life. The long-term, high-dose administration of conventional drugs often results in severe adverse effects. In …

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pH/Hyal-responsive vancomycin-loaded chitooligosaccharide nanoparticles for intracellular MRSA infection treatment

Wenting Li, Weiwei Li, Xuanxiang Zhai, Xiao Liu et autres

, as compared to free Van. Furthermore, HA/COS@Van also demonstrated enhanced bactericidal activity in both mouse acute peritonitis model and mouse organ infection model. Therefore, this active-targeting delivery system may hold promise in advancing therapeutic outcomes for infections related to intracellular pathogens.

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Promising Nanoparticles-Based Oral Therapy for Effective Inhibition of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Xiangjun Chen, Lu Li, Qing Fan, Lingyu Zhang et autres

Portal vein tumor thrombus (PVTT) is a poor prognostic factor for hepatocellular carcinoma (HCC) patients, highlighting the need for an oral drug delivery system that combines convenience, simplicity, biosafety, and improved patient compliance. Leveraging the unique anatomy of the portal vein and …

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Eliminating Intracellular MRSA via Mannosylated Lipid-Coated Calcium Phosphate Nanoparticles

Xiangjun Chen, Xiaoyi Shi, Xiao Liu, Xuanxiang Zhai et autres

(MRSA) within cells proves exceptionally challenging to eradicate using conventional antimicrobials, resulting in recurring infections and heightened resistance. Herein, we reported an innovative mannosylated lipid-coated photodynamic/photothermal calcium phosphate nanoparticle (MAN-LCaP@ICG) for eradicating intracellular MRSA. The MAN-LCaP functioned as the vehicle for drug …

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Advancements in Manganese‐Based Cathode for Sustainable Energy Utilization

Ting Zhou, Binjing Wu, Chengze Li, Xinhuan Zhang et autres

Manganese-based compounds, especially manganese oxides, are one of the most exceptional electrode materials. Specifically, manganese oxides have gained significant interest owing to their unique crystal structures, high theoretical capacity, abundant natural availability and eco-friendly nature. However, as transition metal semiconductors, manganese oxide …

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Active Targeted Janus Theranostic Nanoplatforms Enable Chemo-Photothermal Therapy to Inhibit the Growth of Breast Cancer

Xiangjun Chen, Mingyi Hou, Xinzhong Zhang, Haixin Liu et autres

Nanoscale structures have been developed to serve various functions in cancer therapy, encompassing areas such as diagnosis, biomedical visualization, tissue regeneration, and drug delivery. Based on biocompatible chitosan oligosaccharides (COS) and gold nanorods (GNRs), we designed the drug delivery systems (GNR@polyacrylic acid-Mn@COS …

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