Rachel P. Riechelmann

Spiritual needs and quality of life of cancer patients

Diego de Araujo Toloi, Rachel P. Riechelmann

PURPOSE: Spirituality is important in cancer care. Few studies have assessed the spiritual needs (SN) of cancer patients. The aim of this study was to assess the SN of cancer patients and evaluate its relationship with their health-related quality of life (HRQOL). …

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Patterns of Recurrence and Epidemiological Features of Anal Canal Squamous Cell Carcinoma: An Institutional Cohort Analysis

Artur Lício Júnior, Beatriz Nelli Barbatto, L.P. Genovez, Rachel P. Riechelmann et autres

All articles of this category (opens in new window) Address for correspondence Artur Licio Junior (arturliciojr@gmail.com) Background: Anal canal squamous cell carcinoma (SCC) is rare, representing ~2% of gastrointestinal cancers. Although CRT achieves high local control, 20–35% of patients recur. Understanding clinicopathological …

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Total neoadjuvant treatment in locally advanced rectal cancer: A retrospective multicentre cohort analysis in three cancer centres in Brazil.

Rafael Vanin de Moraes, Elson Santos Neto, Luciano Ipólito Branquinho, Guilherme Rossato de Almeida et autres

77 Background: Total neoadjuvant therapy (TNT) improves overall survival (OS) while maintaining local recurrence-free survival (LRFS) in locally advanced rectal cancer (LARC). Real-world data are essential to refine patient selection and outcomes. Methods: Multicentre retrospective study of LARC patients treated with TNT …

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Once-daily oral paltusotine in the treatment of patients with carcinoid syndrome: Biomarker analysis results from a phase 2, randomized, parallel-group study.

Ana Isabel Oviedo Albor, Amr Mohamed, Rachel P. Riechelmann, Juan Manuel O’Connor et autres

632 Background: Paltusotine is an oral, nonpeptide, selective somatostatin receptor 2 agonist. In a phase 2 study, treatment with once-daily paltusotine reduced the frequency and severity of carcinoid syndrome (CS) symptoms and was well tolerated. The effect of paltusotine on biomarkers of …

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Emerging Diagnostics and Therapies in Neuroendocrine Neoplasms: A Critical Review

Jorge Humberto Hernández-Félix, Mónica Isabel Meneses Medina, Rachel P. Riechelmann, Jonathan Strosberg et autres

Neuroendocrine neoplasms (NENs) are biologically diverse tumors. This article is a critical review of recent evidence focusing on systemic therapies (through mid-2025). We summarize what is most practice-relevant and where gaps remain. In diagnosis, somatostatin-receptor PET/CT has largely replaced older scintigraphy, and …

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Immunotherapy for Metastatic Pancreatic Neuroendocrine Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy

Louis de Mestier, Thorvardur R. Halfdanarson, Leonidas Apostolidis, Anna Koumarianou et autres

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Alkylating-induced hypermutation in pancreatic neuroendocrine tumours

Rodrigo Gomes Taboada, Giovana Tardin Torrezan, Rachel P. Riechelmann

Pancreatic neuroendocrine tumours (PanNET) represent the most chemosensitive subtype of NET, with alkylating agents being the mainstay treatment for advanced-stage disease. However, disease progression remains inevitable and presents significant clinical challenges. Advances in tumour molecular profiling have facilitated a deeper understanding of …

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The East and West consolidated efficacy of radioligand therapy in neuroendocrine tumors

Rachel P. Riechelmann, R. Garcia-Carbonero

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Drug dose optimization and substitutions to improve access for patients with gastrointestinal and neuroendocrine cancers

Rachel P. Riechelmann, Tiago Cordeiro Felismino, B. Müller, Renata D’Alpino Peixoto et autres

The cost of cancer care has significantly increased, with a major cause being the high cost of new drugs, limiting their access worldwide. Drug dose optimization (DDO) and substitutions may help improve treatment access for patients residing in financially resource-limited countries. We …

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791P The effects of prebiotics and probiotics administered during definitive chemoradiation in the fecal microbiota of patients with squamous cell carcinoma of the anal canal (SCCA) enrolled in the BISQUIT trial

Marcos Pedro Guedes Camandaroba, V.S.E. Silva, S. AguiarJr, Thais Fernanda Bartelli et autres

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813P A LATAM record of patients with anal squamous cell carcinoma with and without HIV Infection: ACTION HIV (LACOG 0421) trial

Rachel P. Riechelmann, Marcos Pedro Guedes Camandaroba, P.C. Montenegro Beltran, Alexandre de Mendonça Palladino et autres

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1729P Clinical outcomes of patients with appendiceal neuroendocrine tumors (ANET): A multicentric retrospective cohort study (GTG/LACOG 0119)

Rachel P. Riechelmann, Paola Beltrán, A. Kruschewsky Coutinho Araujo, J.M.R. O'Connor et autres

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