Jana Bieblová

Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition

Patrik Olekšák, Miroslav Psotka, M Vancurová, Olena Sapega et autres

Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and novel compounds was evaluated …

cz, dk (code pays fourni par la source)

P01.16 Effects of the STAT3 inhibitors on senescent tumour cells

Olena Sapega, Romana Mikyšková, Kamil Musílek, Jana Bieblová et autres

Background Cellular senescence is the process of cell proliferation arrest. Premature cellular senescence can be induced by chemotherapy, irradiation and, under certain circumstances, by cytokines. Senescent cells produce a number of secreted proteins and growth factors that may either stimulate or inhibit …

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Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice

Romana Mikyšková, M Indrová, Ivan Štěpánek, Ivan Kanchev et autres

Dendritic cell (DC)-based vaccines pulsed with high hydrostatic pressure (HHP)-inactivated tumor cells have recently been shown to be a promising tool for prostate cancer chemoimmunotherapy. In this study, DC-based vaccines, both pulsed and unpulsed, were as effective as docetaxel (DTX) in reducing …

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Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines

Jana Šímová, Olena Sapega, Terezie Imrichová, Ivan Štěpánek et autres

// Jana Simova 1 , Olena Sapega 1 , Terezie Imrichova 2 , Ivan Stepanek 1 , Lenka Kyjacova 2 , Romana Mikyskova 1 , Marie Indrova 1 , Jana Bieblova 1 , Jan Bubenik 3 , Jiri Bartek 2, 4, 5 …

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IL-12 therapy suppresses TC-1 tumor growth accelerated by admixture of the docetaxel-treated senescent tumor cells

Olena Sapega, Jana Šímová, Terezie Imrichová, Lenka Kyjacová et autres

Cellular senescence is considered to be a principal barrier against tumorigenesis that inhibits acquisition of an immortal phenotype. Tumor cell senescence can be induced by antitumor therapy, such as irradiation or chemotherapy and, under certain circumstances, also by cytokines (IFNγ and TNFα). …

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Resistance of novel mouse strains different in MHC class I and the NKC domain to the development of experimental tumors

Anna Fišerová, Jan Richter, Katarína Čapková, Jana Bieblová et autres

To elucidate the immunological mechanisms critical for tumor progression, we bred novel mouse strains, different in the NKC and H-2D domains. We used inbreeding to generate hybrids of Balb/c and C57BL/6 of stable H-2Db+d-NK1.1neg and H-2Db-d+NK1.1high phenotypes. We analyzed the growth of …

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Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy

Romana Mikyšková, Ivan Štěpánek, M Indrová, Jana Bieblová et autres

High hydrostatic pressure (HHP) has been shown to induce immunogenic cell death of cancer cells, facilitating their uptake by dendritic cells (DC) and subsequent presentation of tumor antigens. In the present study, we demonstrated immunogenicity of the HHP-treated tumor cells in mice. …

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Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes

Veronika Vlková, Ivan Štěpánek, Veronika Hrušková, Filip Šenigl et autres

// Veronika Vlková 1 , Ivan Štěpánek 1 , Veronika Hrušková 1 , Filip Šenigl 2 , Veronika Mayerová 1 , Martin Šrámek 1 , Jana Šímová 1 , Jana Bieblová 1 , Marie Indrová 1 , Tomáš Hejhal 1 , Nicolas …

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DNA demethylating agent 5-azacytidine inhibits myeloid-derived suppressor cells induced by tumor growth and cyclophosphamide treatment

Romana Mikyšková, M Indrová, Veronika Vlková, Jana Bieblová et autres

ABSTRACT MDSCs represent one of the key players mediating immunosuppression. These cells accumulate in the TME, lymphoid organs, and blood during tumor growth. Their mobilization was also reported after CY therapy. DNMTi 5AC has been intensively studied as an antitumor agent. In …

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Administration of anti-CD25 mAb leads to impaired α-galactosylceramide-mediated induction of IFN-γ production in a murine model

Rodney Alexander Rosalia, Ivan Štěpánek, Veronika Polláková, Jana Šímová et autres

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Cyclophosphamide-induced Myeloid-derived Suppressor Cell Population Is Immunosuppressive But Not Identical to Myeloid-derived Suppressor Cells Induced By Growing TC-1 Tumors

Romana Mikyšková, M Indrová, Veronika Polláková, Jana Bieblová et autres

Myeloid-derived suppressor cells (MDSC) play an important role in tumor escape from antitumor immunity. MDSC accumulate in the lymphoid organs and blood during tumor growth and their mobilization was also reported after cyclophosphamide (CY) administration. In this communication, spleen MDSC accumulating after …

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Effects of 5-azacytidine and trichostatin A on dendritic cell maturation.

M Indrová, Jana Bieblová, J Bubeník, Milan Reiniš

Maturation of dendritic cells (DC) towards functional antigen-presenting cells is a complex process, the regulation of which may also involve epigenetic mechanisms. Thus, it is of interest to investigate how gene expression changes during DC maturation can be influenced with epigenetic agents, …

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