Almut Nebel

Genomic insights into preantibiotic osteomyelitis pathogens and their link to current resistant hospital strains

D. Myburgh, Nicolas Antonio da Silva, Anna Lena Flux, Janine Mazanec et autres

OBJECTIVES: Osteomyelitis is a severe bone infection that was frequently fatal before the introduction of antibiotics and remains a significant healthcare burden today. Staphylococcus aureus is the most common cause, alongside other hospital-acquired pathogens. Despite their clinical importance, the evolutionary history of …

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Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

Mara Neuerburg, Larissa Smulders, Erik B. van den Akker, Daniel Kolbe et autres

Abstract Background The increase in human lifespan without a proportional increase in healthspan imposes a substantial burden on individuals and society. Exceptionally long-lived individuals and members of long-lived families exhibit compression of multi-morbidity. Genetics, and in particular rare protein-altering variants, appear to …

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Sequence-based HLA genotyping identifies six candidate alleles associated with human longevity in Germans

Nicolás Mendoza-Mejía, Daniel Kolbe, Onur Özer, Janina Dose et autres

Aims: Human leukocyte antigen (HLA) polymorphism influences immunity by balancing protection against pathogens with the preservation of self-tolerance. This balance has been proposed to affect longevity, and associations with HLA variants have been reported. However, studies in this field have often yielded …

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Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families

Pasquale Putter, Di Guan, Thies Gehrmann, Daniel Kolbe et autres

Abstract Life expectancy has steadily increased in the last two centuries, while healthspan has been lagging behind. Survival into extreme ages strongly clusters within families which often exhibit a delayed onset of (multi)morbidity, yet the underlying protective genetic mechanisms are still largely …

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Detection of Clostridium sporogenes in a Roman-era cattle mass grave at Vilauba

D. Myburgh, Nicolas Antonio da Silva, Magdalena Haller-Caskie, Lídia Colominas et autres

In the ancient Roman world, cattle played an integral role in daily agricultural tasks, providing the means necessary to plow fields, mill grains, and transport goods. The research presented here deals with the remains of 14 cattle discovered in a mass grave …

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HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men

Nicolás Mendoza-Mejía, Daniel Kolbe, Onur Özer, Janina Dose et autres

BACKGROUND: Prior research on the genetics of human longevity has identified only a few robust associations. While these studies highlight the importance of metabolic processes for longevity, the contribution of immune genes, specifically those in the highly polymorphic human leukocyte antigen (HLA) …

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Long-distance kinship in megalithic Europe

Ben Krause‐Kyora, Nicolas Antonio da Silva, Almut Nebel, Daniel Kolbe et autres

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German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway

Daniel Kolbe, Janina Dose, Pasquale Putter, Malte Ziemann et autres

In this study, we investigated the contribution of rare coding variants to human longevity by analyzing whole exome sequencing data from 1245 German long-lived individuals (LLI) and 4105 geographically matched younger controls. We identified novel exome-wide significant associations at both the single-variant …

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Admixture as a source for HLA variation in Neolithic European farming communities

Nicolas Antonio da Silva, Onur Özer, Magdalena Haller-Caskie, Yan-Rong Chen et autres

BACKGROUND: The northern European Neolithic is characterized by two major demographic events: immigration of early farmers from Anatolia at 7500 years before present, and their admixture with local western hunter-gatherers forming late farmers, from around 6200 years before present. The influence of …

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The HLA-B*57:01 Haplotype, Genetic Key Linking Innate Immunity and Longevity

Myriam Rahmouni, Cristina Giuliani, Daniela Colucci, Nicolás Mendoza-Mejía et autres

In our recent research on AIDS Elite controllers, we demonstrated that the HLA-B*57:01 allele is part of an extensive MHC haplotype associated with impaired MICA/MICB function. Considering the pivotal role of natural killer (NK) cells and innate immunity in fighting cancer and …

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Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases

Jhih-Rong Lin, Patrick Sin‐Chan, Valerio Napolioni, Guillermo G. Torres et autres

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Neolithic Yersinia pestis infections in humans and a dog

Julian Susat, Magdalena Haller-Caskie, Joanna H. Bonczarowska, Nicolas Antonio da Silva et autres

Yersinia pestis has been infecting humans since the Late Neolithic (LN). Whether those early infections were isolated zoonoses or initiators of a pandemic remains unclear. We report Y. pestis infections in two individuals (of 133) from the LN necropolis at Warburg (Germany, …

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