Amy Moorehead

Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery

Keyvan Karkouti, Jeannie Callum, Justyna Bartoszko, Kenichi A. Tanaka et autres

Importance: Excessive bleeding is a common and prognostically important complication of cardiac surgery. For bleeding related to coagulation factor deficiency, frozen plasma is the most used therapy. Preliminary trials indicate that 4-factor prothrombin complex concentrate (PCC) may be a suitable alternative. Objective: …

ca, us, ch (code pays fourni par la source)

Correlation of the Transfusion Camp knowledge assessment test with clinical transfusion practice

Bryan Tordon, Harley Meirovich, A. Malkin, Katerina Pavenski et autres

BACKGROUND: It is uncertain how transfusion knowledge translates to practice. The purpose of the study was to determine if higher scores on a validated Transfusion Camp knowledge assessment test were associated with transfusion order appropriateness. STUDY DESIGN AND METHODS: Eligible participants included …

ca, au (code pays fourni par la source)

The seasonal distribution of immune thrombotic thrombocytopenic purpura is influenced by geography: Epidemiologic findings from a multi‐center analysis of 719 disease episodes

Jeremy W. Jacobs, C Stanek, Garrett S. Booth, Argiris Symeonidis et autres

Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes have diminished the ability to perform a rigorous assessment. This 5-year retrospective study assessed the epidemiology of iTTP and determined whether it …

us, gr, ca, it, es, au, fr (code pays fourni par la source)

Human Fc gamma receptor IIIA blockade inhibits platelet destruction in a humanized murine model of ITP

Lázaro Gil, Kevin Doyoon Won, Zoya Tawhidi, Emma Cummins et autres

ABSTRACT: Fc gamma receptor (FcγR) IIIA is an important receptor for immunoglobulin G (IgG) and is involved in immune defense mechanisms as well as tissue destruction in some autoimmune diseases including immune thrombocytopenia (ITP). FcγRIIIA on macrophages can trigger phagocytosis of IgG-sensitized …

ca, de (code pays fourni par la source)

COVID-19: A review on the inflammatory profile of SARS-CoV-2 and the asymptomatic state

Devyani Bakshi, Amy Moorehead, Loubna Akhabir, David Putman et autres

The coronavirus disease 2019 (COVID-19) pandemic caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused significant death, disease burden, and panic worldwide. Several studies have determined that COVID-19 is associated with an exaggerated cytokine storm. SARS-CoV-2 induces …

A thymic stromal lymphopoietin polymorphism may provide protection from asthma by altering gene expression

Amy Moorehead, Raphael Hanna, Delia Heroux, Helen Neighbour et autres

BACKGROUND: Genome-wide association studies have identified associations of the single nucleotide polymorphism rs1837253 in the thymic stromal lymphopoietin (TSLP) gene with asthma, allergic disease and eosinophilia. The TSLP gene encodes two isoforms, long and short, and previous studies have indicated functional differences …

ca (code pays fourni par la source)

THYMIC STROMAL LYMPHOPOIETIN EXPRESSION IN NASAL EPITHELIAL CELLS OF ALLERGIC ASTHMATICS

Amy Moorehead

Thymic stromal lymphopoietin (TSLP), an epithelial-derived cytokine, has a critical role in the development of allergic inflammatory responses and have been implicated in type 2 allergic disease, including asthma, allergic rhinitis, and atopic dermatitis. Genetic polymorphisms in the TSLP gene are among …