Samantha L. Hao

Implementation and outcomes of a rapid response genomic hospital epidemiology programme at an academic medical centre over 7 years

Victoria T. Chu, Natasha Spottiswoode, Ryan Ward, Deborah S. Yokoe et autres

Advances in genomic technologies have revolutionised practices for hospital infection prevention and control programmes. In this Personal View, we describe a genomic epidemiology service called the Rapid Response (RR) programme at University of California, San Francisco, a large academic medical centre. In …

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Host–Microbe Multiomic Profiling Predicts Mortality in Sepsis

Natasha Spottiswoode, Lucile P. A. Neyton, Eran Mick, Katrina Kalantar et autres

RATIONALE: Sepsis is a leading cause of mortality and involves a dysregulated host response to infection. The host and microbe have historically been considered independently in studies of sepsis, limiting our understanding of key relationships driving mortality. OBJECTIVES: We sought to identify …

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The Impact and Outcomes of CSF Metagenomics in the Clinical Practice in a University-based Medical Center (S19.009)

Samantha L. Hao, Susana Dominguez Penuela, Patricia J. Simner, Carlos Pardo‐Villamizar

To evaluate the impact of CSF metagenomic next-generation sequencing (mNGS) on the diagnosis and treatment of neurological syndromes.

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Serum Neurofilament Light Chain Levels are Elevated in Stiff Person Syndrome Spectrum Disorders (P1-14.008)

Maria Regina Reyes, Susana Dominguez Penuela, Samantha L. Hao, Carlos Pardo‐Villamizar et autres

To evaluate serum neurofilament light (sNfL) levels in seropositive Stiff Person Syndrome Spectrum Disorders (SPSD) and compare them with neuroinflammatory cases (multiple sclerosis - MS) and healthy controls (HC).

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In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia

Natasha Spottiswoode, Samantha L. Hao, Estella Sanchez-Guerrero, Angela M. Detweiler et autres

Multidrug-resistant (MDR) Pseudomonas aeruginosa has been declared a serious threat by the United States Centers for Disease Control and Prevention. Here, we used whole genome sequencing (WGS) to investigate recurrent P. aeruginosa bloodstream infections in a severely immunocompromised patient. The infections demonstrated …

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Myelitis and Myelopathies in the Era of COVID-19 (P4-10.003)

Samantha L. Hao, Susana Dominguez Penuela, Maria Reyes‐Mantilla, Paula V. Barreras et autres

To characterize the clinical presentations of myelitis and myelopathies following SARS-CoV2 infection (COVID-19) or vaccination for COVID-19.

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Uncovering the putative pathogenesis of Stiff Person Syndrome (SPS): is there a neuroinflammatory mechanism? (P13-1.007)

Maria Reyes‐Mantilla, Samantha L. Hao, Susana Dominguez Penuela, David Acero-Garces et autres

To determine the profile of immune mediators (e.g., cytokines, chemokines) in the CSF of people with Stiff Person Syndrome (SPS).

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Genomic Epidemiology and Transmission Dynamics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Congregate Healthcare Facilities in Santa Clara County, California

Tara MacCannell, Joshua Batson, Brandon J. Bonin, K C Astha et autres

BACKGROUND: Outbreaks of SARS-CoV-2 in long-term care facilities (LTCFs) cause significant morbidity and mortality. Mapping viral transmission within and between facilities by combining genomic sequencing with epidemiologic investigations enables targeting infection-control interventions. METHODS: We conducted weekly surveillance of residents and staff in …

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Antibiotic-Selected Gene Amplification Heightens Metal Resistance

David A. Hufnagel, Jacob E. Choby, Samantha L. Hao, Anders F. Johnson et autres

to a last-line antibiotic, colistin, resulted in a DNA amplification that does not confer antibiotic resistance but instead facilitates resistance to the toxic metal nickel. This highlights a novel aspect of antibiotic and metal interplay. Concerningly, these data suggest the use of …

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Metagenomic next generation sequencing analysis of vaginal microbiome composition in patients with bacterial vaginosis treated with lactin-v (Lactobacillus crispatus CTV-05) versus placebo

Samantha L. Hao, Gloria R. Castañeda, Craig R. Cohen, Anke Hemmerling et autres

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Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses

Eran Mick, Jack Kamm, Angela Oliveira Pisco, Kalani Ratnasiri et autres

SARS-CoV-2 infection is characterized by peak viral load in the upper airway prior to or at the time of symptom onset, an unusual feature that has enabled widespread transmission of the virus and precipitated a global pandemic. How SARS-CoV-2 is able to …

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Rapid deployment of SARS-CoV-2 testing: The CLIAHUB

Emily D. Crawford, Irene Acosta, Vida Ahyong, Erika C. Anderson et autres

Author(s): Crawford, Emily D; Acosta, Irene; Ahyong, Vida; Anderson, Erika C; Arevalo, Shaun; Asarnow, Daniel; Axelrod, Shannon; Ayscue, Patrick; Azimi, Camillia S; Azumaya, Caleigh M; Bachl, Stefanie; Bachmutsky, Iris; Bhaduri, Aparna; Brown, Jeremy Bancroft; Batson, Joshua; Behnert, Astrid; Boileau, Ryan M; Bollam, …

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