Accès ouvert
2025
article
OpenAlex
Sabine Haggenburg, Cilia R. Pothast, Quincy Hofsink, Nienke J.E. Haverkate et autres
ABSTRACT: Patients with sickle cell disease (SCD) are at increased risk of COVID-19-related mortality compared with healthy individuals, even after vaccination. To what extent impaired vaccine-induced immunity contributes to this risk is unknown. We prospectively investigated vaccine immunogenicity in 31 patients with …
nl, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Elisabeth Dovern, Sterre J.A.M. Nijland, Annemarie Braamse, Maud M. van Muilekom et autres
Abstract Advances in conditioning regimens have made non‐myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) a viable curative option for adults with sickle cell disease (SCD). However, prospective studies comparing pre‐ and post‐transplant patient‐reported health outcomes are scarce. Therefore, in a prospective, mixed‐methods …
nl, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Elisabeth Dovern, Mesire Aydin, Mette D. Hazenberg, Man Tang et autres
Nonmyeloablative, matched sibling donor hematopoietic stem cell transplantation with alemtuzumab/total body irradiation (TBI) conditioning is a curative therapy with low toxicity for adults with sickle cell disease (SCD). However, relatively low donor chimerism levels and graft rejection remain important challenges. We hypothesized …
nl, ch, gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Man Tang, Erfan Nur, Charlotte F.J. Van Tuijn, Bart J. Biemond
Not available.
nl
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Manouk Admiraal, Jonathan van Daalen, Michael W J Ritt, Joost Dekker et autres
OBJECTIVES: Pain management during a vaso-occlusive crisis (VOC) for patients with sickle cell disease (SCD) remains a major challenge and strongly depends on opioids. We developed a multimodality pain protocol for rapid, opioid-sparing pain treatment of VOC and evaluated its feasibility. METHODS: …
nl
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Aafke E. Gaartman, Charlotte F.J. Van Tuijn, Erfan Nur, Liffert Vogt et autres
In sickle cell disease (SCD), reduced estimated glomerular filtration rate (eGFR) and albuminuria are frequently seen and associated with increased mortality in SCD.1 In non-SCD patients, a decline of renal function over time is a risk factor for cardiovascular morbidity and mortality.2 …
nl
(code pays fourni par la source)
2022
article
OpenAlex
Charlotte F.J. Van Tuijn, Mitchel E. van Straaten, Erfan Nur, Bart J. Biemond et autres
Background Patients with Sickle cell disease (SCD) suffer from frequent vaso-occlusive crises (VOC) that heavily contribute to morbidity and mortality. VOC's constitute the principal cause of emergency department (ED) presentation and hospital admission and the ED visit serves to diagnose underlying disorders, …
nl
(code pays fourni par la source)
2022
article
OpenAlex
Aaron Heeren, Charlotte F.J. Van Tuijn, Myrthe J. van Dijk, Eduard J. van Beers et autres
Background Sickle cell disease (SCD) is one of the most common monogenic disorders in the world. People with SCD experience pain due to blood flow obstruction and have musculoskeletal and cardiopulmonary complications, which correspond to different chronic conditions. In other chronic diseases, …
nl
(code pays fourni par la source)
2022
article
OpenAlex
Elisabeth Dovern, Mesire Aydin, Man Tang, Liesbeth E.M. Suijk et autres
Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only established curative treatment option for sickle cell disease (SCD). In adult SCD patients, myeloablative conditioning is associated with significant toxicity, primarily because of cumulative organ damage. Recently, matched sibling donor (MSD) …
nl, ch
(code pays fourni par la source)
2021
conference-abstract
OpenAlex
Man Tang, Erfan Nur, Charlotte F.J. Van Tuijn, Bart J. Biemond
Abstract Introduction Sickle cell disease (SCD) affects millions of people throughout the world. This is caused by a mutation in the hemoglobin gene resulting in abnormal red blood cells. Patients with SCD are in a state of chronic inflammation that is driven …
nl
(code pays fourni par la source)
Accès ouvert
2021
conference-abstract
OpenAlex
Kadère Konté, Erfan Nur, Man Tang, Jarom Heijmans et autres
Abstract Background: Sickle cell disease (SCD) is frequently complicated by painful vaso-occlusive crises (VOCs) often resulting in healthcare utilization including hospital admission. A vaso-occlusive crisis (VOC) can be induced by multiple factors including infection, exposure to cold, physical exercise, dehydration and stress. …
nl
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Kadère Konté, Erfan Nur, Man Tang, Jarom Heijmans et autres
Sickle cell disease (SCD) is frequently complicated by painful vaso-occlusive crises (VOCs) often resulting in healthcare utilization including hospital admission. A vaso-occlusive crisis (VOC) can be induced by multiple factors including infection, exposure to cold, physical exercise, dehydration, and stress. Given the …
nl
(code pays fourni par la source)