Haoliang Fan

Development and validation of a 154-plex MPS STR panel for Illumina and Nanopore: a comprehensive tool for forensic genetic analysis

Mengyang Zhao, Tingting Yang, Linyu Shi, Jie Chen et autres

Capillary electrophoresis (CE)-based STR typing, while long established as the gold standard, is constrained by limited allele resolution and multiplexing capacity—unable to resolve variation within length-identical alleles or to simultaneously capture autosomal, X-, and Y-chromosomal STRs in a single reaction. This restricts …

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A rapid one-step NGS-based system integrating microhaplotypes and SNPs for forensic identification

Linyu Shi, Jiaxuan Hao, Jingjing Xu, Mengyang Zhao et autres

Short tandem repeats (STRs) have limited performance in analysing challenging forensic samples owing to the relatively long amplicon lengths of a subset of STR loci and the presence of stutter artefacts. While single nucleotide polymorphisms (SNPs) offer advantages for degraded DNA analysis …

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Forensic validation and population genetic evaluation of an MPS-based integrated microhaplotype and Y-SNP/STR (MY) system

Haoliang Fan, Qiqian Xie, Fenglong Yang, Wei Sang et autres

, phylogenetic tree, and STRUCTURE, based on data from 26 populations in the 1000 Genomes Project (1KGP) and a Guangdong Han (GDH) cohort. The results indicate that the integrated MH and Y-SNP/Y-STR panel provides complementary information for forensic mixture analysis, paternal-lineage characterization, …

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A multiplex droplet digital PCR methylation assay for forensic age prediction from multiple body fluids: blood, saliva, semen and bloodstains using three DNA methylation markers

Fenglong Yang, Jin Li, Yuntian Xiao, Zhimin Ji et autres

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Integrated genetic and geographic ancestry prediction via large-scale genomic data and machine learning

Jing Chen, Yuguo Huang, Haoliang Fan, Mengge Wang et autres

Understanding fine-scale genetic and geographic ancestry in East and Southeast Asia is difficult due to complex population histories and limited high-resolution genomic data. Here, we introduce a comprehensive framework that combines ancestry-informative single nucleotide polymorphism (AISNP) panels with machine learning to jointly …

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Development and validation of an MPS-based 513-Plex SNP identity panel for degraded forensic samples

Linyu Shi, Xiaoxiao Feng, Mengyang Zhao, Jiarong Zhang et autres

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New strategies for tumor diagnosis and therapy with ultrasound assisted by nanomaterials

Wei Sang, Haoliang Fan, Yijun Huang, Weiqi Gao et autres

With the development of nanomedicine and ultrasound technology, ultrasound-enhanced contrast agents and treatment platforms based on nanomaterials have become important tools for tumor diagnosis and treatment, owing to their high safety profile, low cost and excellent biocompatibility. This review comprehensively discusses the …

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Creation and Exploration of the "Organized Fill-in-the-Blank Format" Discipline Construction Model for Forensic Medicine in the New Era.

Zhiwen Wei, Hongxing Wang, Junhong Sun, Haoliang Fan et autres

Forensic medicine has been designated as a first-level discipline, presenting new opportunities and challenges for the development of forensic medicine. Since the 1980s, the establishment of forensic medicine discipline and the cultivation of high-level forensic talents have become hot topics in the …

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The Impact of Cardiovascular Disease Gene Polymorphism and Interaction with Homocysteine on Deep Vein Thrombosis

Lei-Lei Niu, Haoliang Fan, Jie Cao, Qiu-xiang Du et autres

High Resolution Image Download MS PowerPoint Slide Deep vein thrombosis (DVT) affects vascular health and can even threaten life; however, its pathogenesis remains unclear. Cardiovascular disease (CVD) and DVT share common risk factors, such as dyslipidemia, aging, etc. We aimed to investigate …

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Development and validation of YARN: A novel SE-400 MPS kit for East Asian paternal lineage analysis

Haoliang Fan, Yiran Xu, Yutao Zhao, Kai Feng et autres

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The combined toxic effects of polystyrene microplastics and different forms of arsenic on the zebrafish embryos (Danio rerio)

Zheng Zhang, Xuewei Li, Jia Li, Yupeng Pan et autres

Microplastics have been widely studied for their ability to adsorb heavy metals. In the natural environment, arsenic exists in different forms and its toxicity depends mainly on its form and concentration. However, different forms of arsenic combined with microplastics have yet to …

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Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood–brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1

Jian An Huang, Jiuyang Ding, Xiaohan Wang, Cihang Gu et autres

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