Kathleen E. Mach

Rapid and robust diagnosis of bloodstream infections by single-cell analysis

Siew Mei Chin, Emma Epiphaniou, Evgeny A. Kovtunov, Kathleen E. Mach et autres

Sepsis, a common consequence of bloodstream infection (BSI), is a leading cause of global mortality and morbidity. Diagnosis is challenging and slow due to extremely low pathogen loads and reliance on time-consuming blood culture, necessitating empiric therapy that worsens outcomes and antimicrobial …

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Performance of Urine Tumor DNA Detection in Patients with High-grade Non–muscle-invasive Bladder Cancer Undergoing Repeat Transurethral Resection

Jay Ogunkeye, Eugene Shkolyar, Kathleen E. Mach, Sophia Prendiville et autres

BACKGROUND AND OBJECTIVE: Patients with high-risk non-muscle invasive bladder cancer (NMIBC) experience high recurrence rates and potential understaging, supporting guideline recommendations for repeat transurethral resection (reTUR). However, identifying patients best suited for reTUR remains challenging. Here, we analyze urine tumor DNA (utDNA) …

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PD25-06 USE OF PRE-TREATMENT URINE TO IDENTIFY MUTATIONS FOR TUMOR-INFORMED MINIMAL RESIDUAL DISEASE ANALYSIS IN NMIBC

William Y. Shi, Kevin J. Liu, Kathleen E. Mach, Mohammad S. Esfahani et autres

IP04-26 TOWARDS CLINICAL TRANSLATION OF A REAL-TIME, ARTIFICIAL INTELLIGENCE (AI)-ASSISTED CYSTOSCOPY SYSTEM FOR BLADDER CANCER DETECTION

Calvin C. Zhao, Max Siauw, Liang Qiu, Timothy J. Lee et autres

V15-02 CYSTOWEB, A LONGITUDINAL CYSTOSCOPY VIDEO DATABASE AND PLATFORM: A POWERFUL TOOL FOR SURVEILLANCE, EDUCATION, AND RESEARCH

Calvin C. Zhao, Dave Young, Timothy J. Lee, Liang Qiu et autres

Large multicenter validation of urine RNA profile for urothelial carcinoma detection and surveillance

Kathleen E. Mach, Zachary Kornberg, Eugene Shkolyar, Jin Long et autres

BACKGROUNDCurrent diagnosis and surveillance of bladder cancer rely on cystoscopy, which is invasive and user dependent. The urine mRNA panel, uRNAp, measures expression of 3 genes for identification of bladder cancer. Here we report validation of uRNAp for patients undergoing initial workup …

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CystoDS: a multiclass endoscopy image dataset for artificial intelligence-assisted bladder cancer detection

Timothy J. Lee, Liang Qiu, Jin Long, Kathleen E. Mach et autres

Cystoscopy is a common endoscopic procedure used for the visual inspection of the lower urinary tract, particularly for the detection and surveillance of bladder cancer. Artificial intelligence (AI) strategies could help address the recognized shortcomings of cystoscopy by identifying malignant and non-malignant …

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Field-effect-informed urine liquid biopsy for bladder cancer

William Y. Shi, Kevin J. Liu, Mohammad S. Esfahani, Kathleen E. Mach et autres

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Microbial Product Cocktails for Personalized Cancer Immunotherapy

Yue Yan, Sijia Yang, Kathleen E. Mach, Guoli Chen et autres

The human immune system has evolved to interact with various commensal and pathogenic bacteria in intricate and nuanced ways. While the diversity of bacteria presents fundamental challenges in understanding immune-microbe interactions, it also offers ample opportunities for developing effective immunomodulatory therapies. Here …

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Magnetic retrieval of kidney stones via ureteroscopy in a porcine model

Daniel Massana Roquero, T. Jessie Ge, Grace H. Holton, Zachary Kornberg et autres

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An Organoid Biosensing Platform for Personalized Prognosis of Bladder Cancer

Yue Yan, Mona A. Ahmed, Kathleen E. Mach, Joseph C. Liao et autres

Bladder cancer is a common malignancy with high rates of recurrence and progression. Chemotherapy is employed at various stages of treatment to improve patient outcomes and survival; however, it is sometimes ineffective and often associated with significant side effects. Moreover, growing evidence …

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Abstract 3773: Urine cell-free RNA analysis for bladder cancer detection and monitoring

Kevin J. Liu, William Y. Shi, Monica C. Nesselbush, Nick A. Phillips et autres

Urine is a promising biofluid for bladder cancer (BLCA) detection because it can be collected non-invasively and is in direct contact with the tumor. Urine cell-free RNA is a potential analyte for BLCA detection and molecular characterization but has not been extensively …

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