Hui Lei

Development and Characterization of Litchi Seed Polyphenol-Loaded Camellia Oil Oleogels Based on Citrus Pectin–Lecithin Emulsion Templates

Xinglong Zhao, Hong Niu, Xiujuan Fu, Siwei Chen et autres

Traditional plastic fats are rich in saturated and trans fatty acids, which can lead to chronic diseases. In contrast, camellia oil and litchi seed polyphenols are valuable natural functional ingredients. This work aimed to construct stable camellia oil oleogels using citrus pectin …

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New polyoxygenated fatty acid ester and other constituents from Dendrobium nobile Lindl. and their chemotaxonomic significance

Ting Chen, Dan Zhang, Xiujuan Fu, Siwei Chen et autres

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Des-O-Methyllasiodiplodin Isolated from Xanthostemon chrysanthus Ameliorates Inflammation by Regulating Autophagy

Jianv Wang, Jixiang Xu, Xun Yang, 夏登梅 et autres

Abstract Xanthostemon chrysanthus (F.Muell.) Benth. is a species from the Myrtaceae family with limited phytochemical and pharmacological studies. In this study, ten compounds (1–10) were isolated and purified from X. chrysanthus, among which compound 2, identified as des-O-methyllasiodiplodin (DML), exhibited the most …

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A real-time PPP time transfer model with tropospheric delay constraints based on Galileo HAS for improved time transfer accuracy

Qianqian Chen, Fei Ye, Lei Xu, Hui Lei et autres

Abstract The Galileo navigation system offers a free High Accuracy Service (HAS) to global users via the E6 signal and the Internet, enabling the broad application of real-time precise point positioning (PPP) time transfer. However, tropospheric delay is not only a major …

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Design, synthesis and biological evaluation of novel glutaminyl cyclase inhibitors targeting the CD47-SIRPα axis in breast cancer cells

Rong Li, Weifeng Zhang, Hui Lei, Fanbo Meng et autres

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Refined real-time PPP-based timing via data fusion of meteorological models and Galileo HAS

Xuhai Yang, R. Zhang, Yunyu Ge, Hui Lei et autres

Abstract Galileo high accuracy service (HAS) via Galileo navigation signals has provided state space representation for GPS and Galileo since January 2023. Tropospheric delay remains a dominant error source in HAS-based real-time precise point positioning (PPP) for global positioning and timing applications. …

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Structure Elucidation and Complete NMR Spectral Assignments of New Sesquiterpenes Isolated From Marine Derived Fungus Aspergillus sydowii ‐HB

Baorui Teng, Sijing Liu, Dan Zhang, Xiujuan Fu et autres

ABSTRACT Six sesquiterpene derivative compounds ( 1 – 6 ), including one new 7 R ‐sydowic acid ( 1 ) and five known compounds ( 2 – 6 ) were isolated from the secondary metabolites of Aspergillus sydowii ‐HB. The structures were …

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Integrated genome mining and molecular networking uncover the biosynthetic potential of a novel mangrove-derived strain Streptomyces sp. B1866

Liyuan Jiang, Wenjin Hu, Jinling Qin, Baorui Teng et autres

Mangrove-derived actinomycetes represent a prolific reservoir of natural products, characterized by diverse chemical structures and significant pharmacological properties. Here, a mangrove-derived Streptomyces sp. B1866 was proposed to represent a novel species within the genus Streptomyces due to the low 16S rRNA gene …

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Structure-activity relationship studies of 3,4-disubstitued indole-2-ketone derivatives identify a potent glutaminyl cyclase inhibitor with antitumor activity against breast cancer

Hui Lei, Yingying Jiang, Jiayu Liu, Weifeng Zhang et autres

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Activity guided discovery of dual inhibitors of α-glucosidase and β-glucuronidase from the leaves of Millettia pachycarpa Benth

Yanxi He, Huiqing Xu, Jing Long, Hui Lei et autres

Type 2 diabetes mellitus (T2DM) and cancers are two globally prevalent diseases which can increase the incidence of each other. Intestinal α-glucosidase and β-glucuronidase are key targets for glycaemic control and chemotherapy detoxification, respectively. This study first found that the leaf methanol …

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New polyketides from Liuweizhiji Gegen-Sangshen oral liquid and their anti-inflammatory, hepatoprotective activities in-vitro, and molecular docking analysis

Mengyu Zhang, Baorui Teng, Xin Zhou, Dan Zhang et autres

Liuweizhiji Gegen-Sangshen (LGS) oral liquid, a commercially available health product in China, has attracted extensive attention due to its application in treatment of alcoholic liver disease. Whereas, no studies on the chemical composition of LGS have been reported. In this work, two …

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Discovery of New Azaindole Metallo-Deubiquitinase CSN5 Inhibitors

Pengcheng Lei, Yu‐Hang Yan, Yingying Jiang, Yanjun Wang et autres

CSN5 is responsible for the deneddylation of cullin-RING E3 ubiquitin ligases and is closely linked to the development of various cancers. We previously developed a noncatalytic activity assay platform using novel fluorescent probes derived from azaindole inhibitors, which also highlighted the potential …

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