François Ravenelle

Effects of CB1R inverse agonist, INV ‐202, in patients with features of metabolic syndrome. A randomized, placebo‐controlled, double‐blind phase 1b study

Glenn Crater, Karine Lalonde, François Ravenelle, Michael Harvey et autres

Abstract Aims To evaluate the clinical safety, tolerability, and pharmacokinetic and pharmacodynamic profile of the novel cannabinoid receptor‐1 (CB1R) inverse agonist, INV‐202, in adults with features of metabolic syndrome. Materials and Methods This was a multicentre, randomized, double‐blind, placebo‐controlled, 28‐day repeat‐dose (INV‐202 …

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In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis

Elias Carvalho Padilha, Mengbi Yang, Pranav Shah, Amy Q. Wang et autres

Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder that affects lysosome-related organelles, often leading to fatal pulmonary fibrosis (PF). The search for a treatment for HPS pulmonary fibrosis (HPSPF) is ongoing. S-MRI-1867, a dual cannabinoid receptor 1 (CB1R)/inducible nitric oxide synthase …

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Author response for "Effects of CB1R inverse agonist, INV ‐202, in patients with features of metabolic syndrome. A randomized, placebo‐controlled, double‐blind phase 1b study"

Glenn Crater, Karine Lalonde, François Ravenelle, Michael Harvey et autres

A peripherally restricted cannabinoid-1 receptor inverse agonist promotes insulin secretion and protects from cytokine toxicity in human pancreatic islets

Anindya Ghosh, Marie‐Line Peyot, Yat Hei Leung, François Ravenelle et autres

The cannabinoid receptor CB1R is expressed in pancreatic β-cells; CB1R increased activity is associated with diabetes, obesity, cardiovascular disorders as well as decreased insulin secretion and insulin resistance. CB1R was shown to signal through G-protein coupling as well as β-arrestins in β-cells. …

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Pentamidine blocks hepatotoxic injury in mice

Enpeng Zhao, Ghulam Ilyas, Francesca Cingolani, Jae Ho Choi et autres

Toxin-induced liver diseases lack effective therapies despite increased understanding of the role factors such as an overactive innate immune response play in the pathogenesis of this form of hepatic injury. Pentamidine is an effective antimicrobial agent against several human pathogens, but studies …

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Development of a liposome formulation for improved biodistribution and tumor accumulation of pentamidine for oncology applications

Juliette Mérian, Raquel De Souza, Yannan N. Dou, Sandra N. Ekdawi et autres

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Potentiometric titration for determination of amylose content of starch – A comparison with colorimetric method

Derek X. Duan, Elizabeth Donner, Qiang Liu, Damon Smith et autres

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NMR imaging study of cross-linked high-amylose starch tablets — The effect of drug loading

Y. J. Wang, François Ravenelle, X. X. Zhu

NMR imaging techniques were used to study the effect of drug loading in cross-linked high-amylose starch tablets. The tablets contained acetaminophen with loading levels from 10 to 40 wt%. The absolute amount of the drug released increased with a larger amount of …

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Pharmacokinetics and anaesthetic effects of propofol‐PM: a novel water soluble propofol formulation

Ann E. Rigby‐Jones, J. Robert Sneyd, François Ravenelle, Pascal Vachon et autres

We have investigated the use of amphiphilic diblock copolymers of poly (N-vinyl-2-pyrrolidone) and poly-(d,l-lactide), PVP-PLA, to dissolve propofol inside micelles (30–60 nm) – Propofol-PM. We compared the pharmacokinetics (PK) of propofol in blood and plasma when administered as 1% Diprivan and as …

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ChemInform Abstract: Poly(hydroxyalkanoates): Biorefinery Polymers with a Whole Range of Applications. The Work of Robert H. Marchessault

William J. Orts, Geoffrey A. R. Nobes, Jumpei Kawada, Sophie Nguyen et autres

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article …

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Anaesthetic effects of propofol polymeric micelle: a novel water soluble propofol formulation

François Ravenelle, Pascal Vachon, Ann E. Rigby‐Jones, J. Robert Sneyd et autres

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Poly(hydroxyalkanoates): Biorefinery polymers with a whole range of applications. The work of Robert H. Marchessault

William J. Orts, Geoffrey A. R. Nobes, Jumpei Kawada, Sophie Nguyen et autres

This review describes the characterization and application of poly(hydroxyalkanoates), PHAs, a remarkable family of natural polyesters with a wide array of useful properties and potential applications. It places specific emphasis on the work of Robert H. Marchessault and his many colleagues outlining …