April Kim

Ethanol Self‐Administration Reduces mGlu2 /3 Protein Expression in the Nucleus Accumbens and mGlu2 /3 Activation Suppresses Binge Drinking in Male Mice

Cassandra G. Modrak, Sarah E. Holstein, April Kim, Elizabeth G. Shannon et autres

BACKGROUND: Alcohol use disorder (AUD) is associated with dysregulated glutamatergic signaling within mesocorticolimbic circuits that govern reinforcement and excessive ethanol intake. Group II metabotropic glutamate receptors (mGlu2/3) act primarily as presynaptic autoreceptors that regulate glutamate release. However, how voluntary alcohol intake alters …

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Transmembrane AMPA receptor regulatory protein TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice

Sara Faccidomo, Jessica L. Hoffman, Julie Lee, Ciarra M. Whindleton et autres

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TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice

Sara Faccidomo, Jessica L. Hoffman, Julie Lee, Ciarra M. Whindleton et autres

Background: Behavioral pathologies that characterize alcohol use disorder (AUD) are driven by the powerful reinforcing, or rewarding, properties of the drug. We have shown that glutamate AMPA receptor (AMPAR) activity is both necessary and sufficient for alcohol (ethanol) reinforcement. Transmembrane AMPAR regulatory …

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Off-Label Use of Anticancer Drugs In South Korea

Yong Min Na, Yun Jung Choi, SeungJin Bae, Mathew R.O. et autres

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Polyphenol (-)-Epigallocatechin Gallate Protection from Ischemia/Reperfusion-Induced Renal Injury in Normotensive and Hypertensive Rats

Young Ho Jang, Yong-Hoon Lee, N.H. Park, Hyun-Kyung Shin et autres

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