Dora Hammerl

Supplementary Figure 2 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

Retrieval of ROPN1/B-specific T-cells and TCR genes.

Supplementary Table 2 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

ROPN1/B peptides identified with immunopeptidomics.

Supplementary Figure 3 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

FLY-1A TCR T-cells recognize melanoma tumoroids.

Supplementary Figure 5 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

Extended phenotypes of intra-tumoral and peripheral T-cells following adoptive transfer of FLY-1A TCR T cells.

Supplementary Figure 9 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

Presence of ROPN1 and FLY-1A TCRβ in metastatic TNBC in relation to endogenous T cell phenotype and anti-PD1 response.

Supplementary Figure 6 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

FLY-1A TCR T-cells recognize patient-derived melanoma cells.

Supplementary Figure 8 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

Stepwise approach from retrieval and identification of TCRs to the functional testing of their sensitivity, specificity and reactivity.

Supplementary Figure 4 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

FLY-1A TCR T-cells do not recognize ROPN1-negative and/or HLA-A2-negative tumor cells.

Supplementary Figure 1 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

Expressions of ROPN1/B, NY-ESO1 and MAGE-A4 target antigens in healthy tissues, TNBC and other tumor types.

Supplementary Figure 7 from TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

Dian Kortleve, Dora Hammerl, Mandy van Brakel, Rebecca Wijers et autres

The extent of recognition of the ROPN1 target by FLY-1A TCR T cells correlates with level of expression.

Tumor-associated macrophages: untapped molecular targets to improve T cell-based immunotherapy

Rui M. L. Coelho, Reno Debets, Dora Hammerl

T cell responses are generally curtailed by suppressive mechanisms within the tumor microenvironment (TME) that prevent T cell infiltration and function. Consequently, T cell-based therapies for solid tumors have yielded limited and often non-durable clinical responses. Tumors develop a hostile TME, where …

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Adoptive cell therapy using T cell receptors equipped with ICOS yields durable anti-tumor response

Alexandre Marraffa, Cor Berrevoets, Margherita Mosiello, Rebecca Wijers et autres

Abstract Treatment with adoptively transferred T cells is challenged by limited longevity of therapeutic cells within tumors. To enhance the durability of anti-tumor T cell products, we have created T cell receptors (TCRs) with built-in co-stimulatory molecules. We observed that TCRs coupled …

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