Hermin Aminah Usman

The Impact of Microsatellite Instability and CD8+ Tumor Infiltrating Lymphocytes on Neoadjuvant Chemotherapy Response in Colorectal Cancer: A Prospective Observational Study

Prapanca Nugraha, Yunia Sribudiani, Reno Rudiman, Susanti Susanti et autres

Background: Treatment of colorectal cancer includes surgery and chemotherapy, along with advances in personalised therapies, which focus on achieving safer and more effective outcomes. One of the processes underlying colorectal cancer is microsatellite instability (MSI), and CD8+ Tumor Infiltrating Lymphocytes (TILs) belong …

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Atypical pemphigus foliaceus with pustular lesions: a case series

Miranti Pangastuti, Annisa Sundani, Oki Suwarsa, Endang Sutedja et autres

BACKGROUND: Pemphigus foliaceus usually presents as erosion, scales, and crusts on an erythematous base. Atypical presentations of pemphigus foliaceus, especially with pustular lesions, are exceedingly rare and pose significant diagnostic challenges. This case series highlights two cases of atypical pemphigus foliaceus with …

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The Uncommon Coexistence of Mid-Borderline Leprosy and Generalized Pustular Psoriasis

Hendra Gunawan, Risa Hidayah, Reiva Farah Dwiyana, Trustia Rizqandaru et autres

that primarily affects the skin and peripheral nerves, whereas generalized pustular psoriasis (GPP) is a rare and severe form of psoriasis characterized by widespread sterile pustules and systemic symptoms. Their coexistence is extremely rare due to distinct genetic, immunologic, and epidemiologic profiles. …

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Histopathological Features and p16/p62 Expression as Indicators of High-Risk HPV Co-Infection in Anogenital Condyloma Acuminata

Hermin Aminah Usman, Etis Primastari, Pati Aji Achdiat, Risa Miliawati Nurul Hidayah et autres

Background: Condyloma acuminata (CA) is primarily caused by low-risk human papillomavirus (LR-HPV); however, high-risk HPV (HR-HPV) co-infection is increasingly reported and cannot be reliably distinguished based on clinical appearance alone. Histopathological assessment and selected immunohistochemical markers may help identify lesions with greater …

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Role of NOTCH Intracellular Domain 1 in Lung Metastasis of Salivary Gland Adenoid Cystic Carcinoma

Hermin Aminah Usman, Rakhmiana Rakhmiana, Birgitta Maria Dewayani, Seto A. Sadputranto et autres

Background: Adenoid cystic carcinoma (AdCC) is a malignant salivary gland tumor characterized by a high rate of metastasis. One of the recurrent genetic alterations in AdCC involves NOTCH1, leading to the activation and release of NOTCH intracellular domain 1 (NICD1). The epithelial–mesenchymal …

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Histopathological Progression and Clinicopathologic Factors Associated with Anogenital Condyloma Acuminata: A Pathological Perspective From a Tertiary Hospital in Indonesia

Karimah Ihda Husnayain, Hermin Aminah Usman, Etis Primastari, Pati Aji Achdiat

Background: Anogenital condyloma acuminata (CA) is a benign lesion caused by low-risk human papillomavirus (HPV). Although typically benign and non-dysplastic, a subset may undergo histopathological progression. Histopathology is essential not only for diagnosis but also for early detection of malignant transformation. In …

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Integrative Computational and Transcriptional Analysis of NF-κB and HIF-1α Modulation Following Doxorubicin Treatment in Triple-Negative Breast Cancer Cells

Nurul Utami, Arif Setiawansyah, Muhammad Hasan Bashari, Hermin Aminah Usman et autres

Nurul Utami,1,2 Arif Setiawansyah,3 Muhammad Hasan Bashari,4 Hermin Aminah Usman,5 Raden Yohana Azhar,6 Astrid Feinisa Khairani4 1Doctoral Program in Medical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 2Department of Anatomy, Anatomical Pathology, and Histology, Faculty of Medicine, Universitas Lampung, Bandar Lampung, …

Cytotoxic Effects of Imperata cylindrica Root Ethanol Extract on the Expression of PKCα, STAT3, and mTOR in A549 Lung Cancer Cell Line

R. Anita Indriyanti, Eko Fuji Ariyanto, Hermin Aminah Usman, Ristaniah Rose Effendy et autres

Background: Imperata cylindrica or Cogon grass is a medicinal plant that has an anticancer effect.We unravel the cytotoxic effect of Imperata cylindrica root ethanol extract on the expression of PKCα, STAT 3 and mTOR in A549 lung cancer cell lines.Methods: The cytotoxic …

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Integrative Computational and Transcriptional Analysis of NF-κB and HIF-1α Modulation Following Doxorubicin Treatment in Triple-Negative Breast Cancer Cells

Nurul Utami, Arif Setiawansyah, Muhammad Hasan Bashari, Hermin Aminah Usman et autres

Purpose: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited targeted treatment options. Doxorubicin remains a cornerstone of TNBC treatment; however, its molecular effects beyond canonical cytotoxic mechanisms are not fully characterized. This study aimed to explore NF-κB- and …

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Inverted Follicular Keratosis in Young Adult: A Rare Entity in the Differential Diagnosis of Skin Tumors

Eva Krishna Sutedja, Endang Sutedja, Kartika Ruchiatan, Yuri Yogya et autres

Introduction: Inverted follicular keratosis (IFK) is a rare benign tumor arising from the follicular infundibulum, typically presenting as a solitary lesion on the head and neck of older adults. The actual incidence of inverted follicular keratosis is likely underreported due to frequent …

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Uncommon Presentation of a Benign Brenner Tumor Mimicking Malignancy: A Case Report

Sulaeman A. Susilo, Ali Budi Harsono, Hermin Aminah Usman

Background and Aims: Brenner tumor (BT) is a rare ovarian epithelial tumor, with approximately 95% of cases being benign. Because of its rarity and nonspecific clinical radiological features, benign BT may mimic ovarian malignancy. We present a case of a benign BT …

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Skin Metastasis from Cervical Adenocarcinoma with Intrapulmonary Metastasis and Metachronous Ovarian Cancer Responding to Chemotherapy: A Case Report and Review

Eva Krishna Sutedja, Endang Sutedja, Kartika Ruchiatan, Yogi Faldian et autres

Skin metastasis, a rare occurrence in cervical cancer, typically signifies advanced systemic disease with a poor prognosis. This case report presents a 55-year-old female with recurrent cervical adenocarcinoma, intrapulmonary metastasis, and metachronous mucinous ovarian cancer who developed skin metastasis. The patient presented …

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