Seong Kyu Baek

Identification of Predictive Biomarkers for Chemoradiotherapy Response in Rectal Cancer

Mee‐Na Park, Junho Kang, Jeong-Woo Hwang, Hye Won Lee et autres

PURPOSE Chemoradiotherapy (CRT) is a standard treatment for rectal cancer, yet patients show marked variability in response. Identifying reliable biomarkers that predict CRT response remains an unmet clinical need. METHODS Pretreatment biopsy samples from patients who received neoadjuvant CRT were analyzed using …

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Inferior Mesenteric Artery Ligation Level and Anastomotic Leakage in Low Anterior Resection

Chang Hyun Kim, Soo Yeun Park, Soo Young Lee, Gyung Mo Son et autres

Importance: The optimal level of inferior mesenteric artery (IMA) ligation during rectal cancer resection remains controversial because of potential trade-offs between anastomotic integrity and functional outcomes. Objective: To determine whether low ligation of the IMA reduces the rate of anastomotic leakage compared …

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Bowel Stimulation Before Loop Ileostomy Closure Using Probiotics: Study Protocol for a Randomized Controlled Trial at a Single Center.

Kyeong Eui Kim, SungUk Bae, Seong Kyu Baek, Woon Kyung Jeong

Background: Low anterior resection syndrome (LARS) is a common functional problem after sphincter-preserving rectal cancer surgery and includes urgency, frequent bowel movements, clustering, and fecal incontinence. Diverting ileostomy may further disrupt the intestinal environment and alter the gut microbiota, potentially worsening bowel …

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Bowel Stimulation Before Loop Ileostomy Closure Using Probiotics: Study Protocol for a Randomized Controlled Trial at a Single Center

Kyeong Eui Kim, Sung Uk Bae, Seong Kyu Baek, Woon Kyung Jeong

Abstract Background Low anterior resection syndrome (LARS) is a common functional problem after sphincter-preserving rectal cancer surgery and includes urgency, frequent bowel movements, clustering, and fecal incontinence. Diverting ileostomy may further disrupt the intestinal environment and alter the gut microbiota, potentially worsening …

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Prognostic significance of integrating pretreatment biopsy-derived Immunoscore and Pan-Immune-Inflammation value in locally advanced rectal cancer after neoadjuvant chemoradiotherapy

Min Suk Kim, Hye Won Lee, Da In Shin, Woon Kyung Jeong et autres

Introduction Despite widespread adoption of neoadjuvant chemoradiotherapy (nCRT), locally advanced rectal cancer (LARC) shows highly heterogeneous treatment responses and survival outcomes. Pretreatment biopsy-derived Immunoscore (IS B ) and the pan-immune-inflammation value (PIV) reflect local and systemic inflammation, respectively, and each has demonstrated …

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Abstract 4643: Microsatellite instability as a determinant of chemoradiotherapy sensitivity in colorectal cancer: Integrated clinical, radiomic, and 3D organoid-based analyses

Hyowon Hong, S H Kim, Sang Jun Byun, Seong Kyu Baek et autres

Abstract Background: Microsatellite instability (MSI) is an established biomarker affecting immunotherapy outcomes and may influence DNA damage responses following chemoradiotherapy (CRT). While clinical studies have reported favorable CRT outcomes in MSI-high (MSI-H) colorectal tumors, the biological basis for differential radiosensitivity remains incompletely …

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Prognostic Impact of Preoperative SARC-F Score on Cancer-Specific Survival in Patients with Colorectal Cancer

Dain Shin, SungUk Bae, Woon Kyung Jeong, Seong Kyu Baek

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Safety and patient’s satisfaction of preoperative carbohydrate drink until 2 hours before colorectal cancer surgery: a single-center, prospective randomized controlled trial

Yun Min Lee, Kyeong Eui Kim, Sung Uk Bae, Seong Kyu Baek et autres

PURPOSE: Traditionally, fasting from midnight has been a standard practice in elective surgery for reduce the risk of aspiration. However, Enhanced Recovery After Surgery (ERAS) programs recommend clear fluid intake until 2 hours before anesthesia. This study aimed to evaluate the safety …

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Prognostic impact of preoperative Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls score on oncologic outcomes in colorectal cancer patients

Dain Shin, Sung Uk Bae, Woon Kyung Jeong, Seong Kyu Baek

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Preoperative Strength, Assistance in Walking, Rising From a Chair, Climbing Stairs, and Falls (SARC‐F) Score Predicts Adjuvant Chemotherapy Discontinuation in Patients With Colorectal Cancer

Dain Shin, Nak‐Hoon Son, Woon Kyung Jeong, Seong Kyu Baek et autres

BACKGROUND AND OBJECTIVES: Sarcopenia adversely affects clinical outcomes in patients with cancer. Studies indicate that sarcopenia significantly predicts chemotherapy-induced dose-limiting toxicities, including early discontinuation, delay, and dose-reduction, in patients with colorectal, esophageal, digestive, hepatocellular, and renal cancers. The Strength, Assistance for walking, …

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The articulated laparoscopic total mesorectal excision for rectal cancer (ATOME trial): a single-arm, prospective trial with pre-specified comparison to robotic surgery

Kyeong Eui Kim, Sung Uk Bae, Seung Hyun Lee, Daero Lim et autres

BACKGROUND: Laparoscopic total mesorectal excision (TME) has become the standard surgical treatment for rectal cancers, despite being a technically challenging procedure due to the straight and rigid nature of the laparoscopic instrument within a narrow bony pelvis. A robotic system with multi-joint …

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Fournier’s gangrene with anal cancer: a case report and literature review

Yunmin Lee, Kyeong Eui Kim, Chan Hee Park, Jeongwoo Lee et autres

Fournier's gangrene (FG) is a rapidly progressing necrotizing fasciitis affecting the perineum and perianal area, often necessitating urgent surgical intervention. While commonly associated with diabetes, immunosuppression, and infections, malignancy-related FG is uncommon. A 59-year-old female presented with severe left buttock pain and …

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