2026
conference-abstract
OpenAlex
Mari I. Suominen, Katja M. Fagerlund, Mervi Ristola, Justyna Zdrojewska et autres
Abstract Natural killer (NK) cells are an essential part of the innate immune system as they can recognize and eliminate various cells in distress, such as virus-infected and tumor cells. Several promising therapeutics based on NK cell function are currently being developed …
fi, se, no
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Accès ouvert
2025
conference-abstract
OpenAlex
Thorstein Boxaspen, Hannah Cuthbertson Husbyn, Kim Anh Giang, C. Heinz et autres
Abstract T cell-based therapies have transformed the treatment landscape for multiple myeloma (MM). However, most patients receiving autologous CAR-T therapy ultimately relapse, and allogeneic T cell products face significant clinical hurdles, including the risk of graft-versus-host disease. Additionally, T cell engagers are …
no, se, fi
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Accès ouvert
2025
preprint
OpenAlex
Minoru Kanaya, Camille Philippon, Herman Netskar, Michelle Sætersmoen et autres
Induced pluripotent stem cell (iPSC)-derived natural killer (iNK) cells offer a promising platform for off-the-shelf immunotherapy against hematological malignancies. NK cell function is dynamically regulated through education driven by inhibitory receptors, including CD94/NKG2A and killer cell immunoglobulin-like receptors (KIR). However, the acquisition …
no, se, us
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Accès ouvert
2024
article
OpenAlex
Michelle Sætersmoen, Ivan S. Kotchetkov, Lamberto Torralba‐Raga, Jorge Mansilla‐Soto et autres
Background Human leukocyte antigen (HLA)-E is overexpressed by a large proportion of solid tumors, including malignant glioblastoma, and acts as a major checkpoint for NKG2A + CD8 + T cells and natural killer (NK) cells in the tumor microenvironment and circulation. This …
no, us, se
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Accès ouvert
2024
article
OpenAlex
Daniel Palacios, Rakesh Kumar Majhi, Edina K. Szabo, Dennis Clement et autres
G protein-coupled receptors (GPCRs) represent the largest family of surface receptors and are responsible for key physiological functions, including cell growth, neurotransmission, hormone release, and cell migration. The GPCR 56 (GPR56), encoded by ADGRG1, is an adhesion GPCR found on diverse cell …
no, in, pl, fi, se
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Accès ouvert
2024
article
OpenAlex
Quirin Hammer, Karlo Perica, Rina M. Mbofung, Hanna van Ooijen et autres
Allogeneic cellular immunotherapies hold promise for broad clinical implementation but face limitations due to potential rejection of donor cells by the host immune system. Silencing of beta-2 microglobulin (B2M) expression is commonly employed to evade T cell-mediated rejection by the host, although …
se, us, no
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Accès ouvert
2023
preprint
OpenAlex
Michelle Sætersmoen, Ivan S. Kotchetkov, Lamberto Torralba‐Raga, Jorge Mansilla‐Soto et autres
Abstract HLA-E is overexpressed by approximately 80% of solid tumors, including malignant glioblastoma, and is emerging as a major checkpoint for NKG2A + CD8 + T cells and NK cells in the tumor microenvironment and circulation. This axis operates side-by-side with PD-L1 …
no, us, se
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Accès ouvert
2023
preprint
OpenAlex
Quirin Hammer, Karlo Perica, Hanna van Ooijen, Rina M. Mbofung et autres
SUMMARY Allogeneic cell therapies hold promise for broad clinical implementation, but face limitations due to potential rejection by the recipient immune system. Silencing of beta-2-microglobulin ( B2M ) expression is commonly employed to evade T cell-mediated rejection, although absence of B2M triggers …
se, us, no
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Accès ouvert
2023
article
OpenAlex
Dennis Clement, Edina K. Szabo, Silje Zandstra Krokeide, Merete Thune Wiiger et autres
Cytotoxic lymphocytes eliminate cancer cells through the release of lytic granules, a specialized form of secretory lysosomes. This compartment is part of the pleomorphic endolysosomal system and is distinguished by its highly dynamic Ca2+ signaling machinery. Several transient receptor potential (TRP) calcium …
no, us, kr, de, gb, in, se
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Accès ouvert
2023
article
OpenAlex
Kim Anh Giang, Thorstein Boxaspen, Yumei Diao, Johan Nilvebrant et autres
We describe the development and characterization of the (to date) smallest Natural Killer (NK) cell re-directing human B Cell Maturation Antigen (hBCMA) x CD16 dual engagers for potential treatment of multiple myeloma, based on combinations of small 58 amino acid, non-immunoglobulin, affibody …
se, no
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2022
article
OpenAlex
Quirin Hammer, Karlo Perica, Rina M. Mbofung, Hanna van Ooijen et autres
Allogeneic cell therapies hold promise to be cost effective with scaled manufacturing for multi-dosing and on-demand off-the-shelf availability. A critical consideration for allogeneic cell products is their ability to persist, maintain function and avoid rejection by the patient's immune system. Genetic knockout …
se, us, no
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2022
article
OpenAlex
Kim Anh Giang, Mizuha Kanaya, Thorstein Boxaspen, Minoru Kanaya et autres
The re-direction of natural killer (NK) cells is an emerging strategy for cancer immunotherapy. We describe the development and characterization of the so far smallest NK cell re-directing hBCMA x CD16 dual engagers for potential multiple myeloma treatment based on combinations of …
se, no
(code pays fourni par la source)