Accès ouvert
2026
article
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Abstract Small cell lung cancer (SCLC) is one of the most aggressive malignancies, characterized by rapid metastatic dissemination and poor overall survival. Despite harboring excessive alterations, expectedly resulting in immunogenic neoantigens, patients with SCLC remain largely refractory to immunotherapy. We found abundant …
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Accès ouvert
2026
dataset
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Supplementary Material 1. Figure S1-S17.
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Accès ouvert
2026
dataset
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Supplementary Material 3. Supplementary Tables S1-S5. Table S1: S1A) Mutationcount in cancers from the COSMIC database. S1B) Mutation count inthe SCLC_George cohort. S1C) List of all cellular models employed experimentallyin our study. S1D) TCGA cancer types and abbre-viations. TableS2: S2A) Full kinome …
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Accès ouvert
2026
dataset
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Supplementary Material 3. Supplementary Tables S1-S5. Table S1: S1A) Mutationcount in cancers from the COSMIC database. S1B) Mutation count inthe SCLC_George cohort. S1C) List of all cellular models employed experimentallyin our study. S1D) TCGA cancer types and abbre-viations. TableS2: S2A) Full kinome …
de, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Supplementary Material 1. Figure S1-S17.
de, us
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Accès ouvert
2026
article
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Supplementary Material 2: Uncropped blot images.
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Accès ouvert
2026
article
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Supplementary Material 2: Uncropped blot images.
de, us
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Additional file of A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer
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Accès ouvert
2026
article
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Supplementary Material 1. Figure S1-S17.
de, us
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker et autres
Additional file of A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer
de, us
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2026
preprint
OpenAlex
Lucia A. Torres Fernández, Volker Boehm, Joel Kaufmann, Agnieszka Rumińska et autres
Summary Small cell lung cancer (SCLC) is among the deadliest cancers with excessive somatic alterations, expectedly resulting in immunogenic epitopes. However, patient benefit from immunotherapy is limited. We found abundant frameshift mutations in SCLC, regarded as highly immunogenic, counterbalanced by a hyperactive …
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2026
conference-abstract
OpenAlex
Lucia A. Torres Fernández, Volker Boehm, Joel Kaufmann, Agnieszka Rumińska et autres
Abstract Small cell lung cancer (SCLC) is a highly aggressive cancer with one of the highest tumor mutational burden (TMB), but patients show only limited response to immunotherapy. The nonsense-mediated decay (NMD) pathway is responsible for the degradation of mutant transcripts thereby …
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