Cynthia Aparecida Bueno de Toledo Osório

Overall survival of patients with second primary breast cancer associated with molecular subtype and epidemiological profile at a cancer center

Ariane Silva da Rocha, Gisele Aparecida Fernandes, Cynthia Aparecida Bueno de Toledo Osório, Ruffo Freitas‐Júnior et autres

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342P Decoding male breast cancer: A molecular perspective on diagnosis and treatment

Priscila Machado de Cerqueira, Fernando Augusto Batista Campos, André Luiz Cicilini, Higor Kassouf Mantovani et autres

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Abstract P3-11-30: Low Ki67 is associated with a lower pathological complete response rate after neoadjuvant therapy in HER2-positive breast cancer patients

B. S. S. De Silva, Mario Machado Lopes, Vladmir Cláudio Cordeiro de Lima, Solange Moraes Sanches et autres

Abstract Introduction: The expression of the Ki67 protein assessed by immunohistochemistry (IHC) can estimate the cell proliferation rate and, therefore, be used as a prognostic biomarker to stratify breast cancer patients who harbor a high risk of disease relapse and can benefit …

Downregulation of DNAJC12 Expression Predicts Worse Survival for ER-Positive Breast Cancer Patients

P.L. Gatti, Flávia Rotea Mangone, Ana Carolina Pavanelli, Suely Nonogaki et autres

Background: DNAJC12 (DnaJ heat shock protein family (Hsp40) member C12) encodes a member of the molecular chaperone Hsp40/DnaJ family, which are important protein folding and proteostasis regulators. Its role as a biomarker has been studied for a limited number of cancer types. …

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MRI features of breast cancer immunophenotypes with a focus on luminal estrogen receptor low positive invasive carcinomas

Carla Chizuru Tajima, Fernanda Pini Sapata Gonçalves Arruda, Victor Chequer Mineli, Julianna Moura Ferreira et autres

To compare the magnetic resonance imaging (MRI) features of different immunophenotypes of breast carcinoma of no special type (NST), with special attention to estrogen receptor (ER)-low-positive breast cancer. This retrospective, single-centre, Institutional Review Board (IRB)-approved study included 398 patients with invasive breast …

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Weakly-supervised deep learning models enable HER2-low prediction from H &E stained slides

Renan Valieris, Luan V. C. Martins, Alexandre Defelicibus, Adriana Passos Bueno et autres

BACKGROUND: Human epidermal growth factor receptor 2 (HER2)-low breast cancer has emerged as a new subtype of tumor, for which novel antibody-drug conjugates have shown beneficial effects. Assessment of HER2 requires several immunohistochemistry tests with an additional in situ hybridization test if …

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Prognostic value of Maspin protein level in patients with triple negative breast cancer

Renan Gomes do Nascimento, Mércia Patrícia Ferreira Conceição, Daniel Rodrigues de Bastos, Cynthia Aparecida Bueno de Toledo Osório et autres

The search for prognostic markers in breast cancer has bumped into a typical feature of these tumors, intra and intertumoral heterogeneity. Changes in the expression profile, localization of these proteins or shedding to the surrounding stroma can be useful in the search …

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Pseudolactational secretory hyperplasia (pregnancy-like hyperplasia) with atypia: a case series and literature review

Samira Juliana de Moraes Machado, Marina Sonagli, Fernanda Perez Magnani Leite, Cynthia Aparecida Bueno de Toledo Osório et autres

Introduction: Pseudolactational secretory hyperplasia (PLH) or pregnancy-like (pseudolactational) hyperplasia is a rare condition associated with an incidental finding in biopsies investigating benign and malignant breast lesions. These lesions affect non-pregnant women, typically between the 4th and 6th decades of life, with no …

Myositis Ossificans of the Breast Mimicking Breast Cancer: A Case Report

Marina Sonagli, Tábata Alves Domingos, Isabela Bartelli Fonseca, Arthur Ferrari de Arruda et autres

Myositis ossificans (MO) is an uncommon tumor characterized by a rapidly growing mass following a history of local trauma. Few cases of MO affecting the breast have been reported, and some were misdiagnosed as primary osteosarcoma of the breast or metaplastic breast …

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Systemic immune mediators reflect tumour‐infiltrating lymphocyte intensity and predict therapeutic response in triple‐negative breast cancer

Ananda D. Lopes, Nayane A. L. Galdino, Amanda Braga Figueiredo, Rafael Canfield Brianese et autres

Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer (BC). Neoadjuvant chemotherapy has proven efficacy in its treatment, and a pathological complete response (pCR) to therapy is predictive of improved long-term survival. The immune response is key to successful neoadjuvant …

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Benefits of a standardized protocol for axillary management after neoadjuvant chemotherapy in a single center.

Marina de Paula Canal, Caroline Gomes de Almeida Rocha, Almir Galvão Vieira Bitencourt, Marina Sonagli et autres

ABSTRACT: Introduction: The axillary lymph node status is one of the most important prognostic factors in breast cancer. For locally advanced tumors, neoadjuvant chemotherapy favors higher rates of breast lumpectomy and downstaging tumor burden of axilla. The aim of this study was …

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Overall survival in patients with second primary breast cancer

Ariane Silva da Rocha, Gisele Aparecida Fernandes, Cynthia Aparecida Bueno de Toledo Osório, Ruffo Freitas‐Júnior et autres

Objective: The objective of this study was to analyze the overall survival of patients with second primary synchronous and metachronous breast cancer. Methodology: A retrospective cohort study on women with second primary breast cancer, diagnosed between 2000 and 2015, was conducted. The …

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