Masa‐aki Kawashiri

Energy spectrum-based correction of washout rates in dual-isotope 123I-BMIPP/201Tl imaging

Kenichi Nakajima, Shotoku Makida, Masato Okamura, Masa‐aki Kawashiri et autres

Abstract Background Myocardial metabolism and perfusion in patients with ischemic heart disease or cardiomyopathy can be simultaneously assessed using 123 I-β-methyl-iodophenyl-pentadecanoic acid (BMIPP) and 201 Thallium (Tl) dual-isotope images. However, cross-contaminated counts between these tracers complicate quantitative analyses, particularly of 123 I-BMIPP …

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Energy spectrum-based correction of washout rates in dual-isotope 123I-BMIPP/201Tl imaging

Kenichi Nakajima, Shotoku Makida, Masato Okamura, Masa‐aki Kawashiri et autres

我が国における脂質代謝の現状と最新の治療

隼人 多田, 正和 山岸, 剛照 川尻, 雅之 高村 et autres

Impact of Genetic Testing Among Patients With Familial Hypercholesterolemia on Adverse Cardiovascular Events ― The Hokuriku-Plus Familial Hypercholesterolemia Registry Study ―

Hayato Tada, Yasuaki Takeji, Chiaki Goten, Hirofumi Okada et autres

BACKGROUND: We aimed to clarify the impact of genetic testing on major adverse cardiovascular events (MACE) among patients with heterozygous familial hypercholesterolemia (HeFH) using data from the Hokuriku-plus FH Registry (UMIN000038210). METHODS AND RESULTS: In all, 431 patients were enrolled in the …

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Beyond Familial Hypercholesterolemia: Your Feet can Help Predict Your Coronary Atherosclerosis

Masa‐aki Kawashiri, Hayato Tada

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A Catalog of the Pathogenic Variants in ABCG5 and ABCG8 and Clinical Features in Sitosterolemia

Takeshi Okada, Shizuya Yamashita, H Tada, Kazuhisa Tsukamoto et autres

AIM: Since comprehensive data on the pathogenic variants of ABCG5 and ABCG8 and clinical features in sitosterolemia remain limited, we aimed to compile a catalog through an extensive literature search of case reports from 2002 to 2024, as well as an evaluation …

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Sex Differences in the Diagnosis and Treatment of Japanese Patients With Familial Hypercholesterolemia: A Retrospective Cohort Study

Hayato Tada, Nobuko Kojima, Atsushi Nohara, Masa‐aki Kawashiri et autres

Objective: Significant sex differences have been observed in the diagnosis and treatment of familial hypercholesterolemia (FH). This study aimed to clarify sex differences among Japanese FH patients. Methods: We assessed Japanese patients who had been clinically diagnosed with heterozygous FH (HeFH) at …

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Efficacy and Safety of Evinacumab in Japanese Patients with Homozygous Familial Hypercholesterolemia: Long-term Results from an Open-label, Single-arm, Phase 3 Trial

Masahiro Koseki, Hisashi Makino, Yoshihiko Otsubo, Masa‐aki Kawashiri et autres

AIM: This sub-group analysis evaluated the long-term efficacy and safety of evinacumab, an angiopoietin-like 3 inhibitor, in adolescent and adult Japanese patients with homozygous familial hypercholesterolemia (HoFH) who were enrolled in the open-label, single-arm, extension of the Phase 3 ELIPSE HoFH pivotal …

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Significance of Clinical and Genetic Signatures of Familial Hypercholesterolemia Among Patients With Severe Hypercholesterolemia

Hayato Tada, Atsushi Nohara, Soichiro Usui, Kenji Sakata et autres

BACKGROUND: Familial hypercholesterolemia (FH) is diagnosed based on clinical signs of FH, including family history and/or xanthomas, or pathogenic FH-variant. OBJECTIVES: The authors aimed to clarify whether these signatures are associated with coronary artery disease (CAD) events beyond low density lipoprotein (LDL) …

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Triple assessments of atherosclerosis in patients with heterozygous familial hypercholesterolemia

Hayato Tada, N Kojima, A Nomura, S Usui et autres

Abstract Background Data on the appropriate timing and impact of atherosclerosis assessment in patients with heterozygous familial hypercholesterolemia (HeFH) are limited. We aimed to determine when atherosclerotic changes occur and the utility of triple assessments of carotid plaque, coronary plaque, and coronary …

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Impact of the clinical diagnostic strata of familial hypercholesterolemia on risk stratification among patients with hypercholesterolemia

Hayato Tada, A Nohara, S Usui, K Sakata et autres

Abstract Background and Aims In 2022, the Japan Atherosclerosis Society (JAS) revised clinical diagnostic criteria of familial hypercholesterolemia (FH), adopting the use of definite, probable, possible, and unlikely FH categories following the Dutch Lipid Clinic Network (DLCN) FH criteria. However, whether these …

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Prevalence, and its impact of a pathogenic CYP27A1 variant on phenotypes among patients with monogenic heterozygous familial hypercholesterolemia

Hayato Tada, Nobuko Kojima, Masa‐aki Kawashiri, Masayuki Takamura

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