Helena Gylling

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo et autres

BACKGROUND: Elevated low-density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole-body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial. OBJECTIVES: This post hoc study concerns the impact of …

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The profile of cholesterol metabolism does not interfere with the cholesterol-lowering efficacy of phytostanol esters

Helena Gylling, Katariina Öörni, Lotta Nylund, Ingmar Wester et autres

BACKGROUND & AIMS: Increasing evidence suggests that high cholesterol absorption efficiency enhances the risk of atherosclerotic cardiovascular diseases. It is not known whether inhibiting cholesterol absorption has different metabolic effects in high- vs. low cholesterol absorbers. We evaluated the effects of phytostanol …

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First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods

Dieter Lütjohann, Ingemar Björkhem, Silvia Friedrichs, Anja Kerksiek et autres

Serum concentrations of lathosterol, the plant sterols campesterol and sitosterol and the cholesterol metabolite 5α-cholestanol are widely used as surrogate markers of cholesterol synthesis and absorption, respectively. Increasing numbers of laboratories utilize a broad spectrum of well-established and recently developed methods for …

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15. Phytosterol consumption and coronary artery disease

Piia Simonen, Chaiyasit Sittiwet, Markku Nissinen, Helena Gylling

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Kasvisterolit, kolesterolin esiasteet ja oksisterolit : pienet määrät, suuret vaikutukset

Vesa M. Olkkonen, Helena Gylling, Elina Ikonen

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Elevated serum squalene and cholesterol synthesis markers in pregnant obese women with gestational diabetes mellitus

Helena E. Miettinen, Kristiina Rönö, Saila B. Koivusalo, Beata Stach‐Lempinen et autres

We examined serum cholesterol synthesis and absorption markers and their association with neonatal birth weight in obese pregnancies affected by gestational diabetes mellitus (GDM). Pregnant women at risk for GDM (BMI >30 kg/m²) were enrolled from maternity clinics in Finland. GDM was …

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Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

Dorota Kamińska, Maija Hämäläinen, Henna Cederberg, Pirjo Käkelä et autres

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Genetic Risk Score Does Not Predict the Outcome of Obesity Surgery

Pirjo Käkelä, Tiina Jääskeläinen, Jaana Torpström, Ivar Ilves et autres

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[Fatty fish modifies HDL particle size and lipid concentrations].

Laura Joukamo, Maria Lankinen, Ursula Schwab, Pasi Soininen et autres

BACKGROUND: We investigated with 1HNMR-spectroscopy the effects of habitual fatty fish intake on serum lipiprotein profiles in persons with features of metabolic syndrome. MATERIAL AND METHODS: The participants (n = 105) were randomized into three diet intervention groups. The groups were given …

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Diet and cardiovascular health in asymptomatic normo- and mildly-to-moderately hypercholesterolemic participants – baseline data from the BLOOD FLOW intervention study

Maarit Hallikainen, Janne Halonen, Jussi Konttinen, Harri Lindholm et autres

BACKGROUND: For decades in Finland, intensive population strategies and preventive activities have been used to lower the risk of atherosclerotic coronary heart disease (CHD). Lifestyle changes, with the emphasis on diet, play an important role in preventive strategies. The aim of this …

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Rasvainen kala muokkaa HDL-hiukkaskokoa ja lipidipitoisuuksia [Fatty fish modifies HDL particle size and lipid concentrations]

Laura Joukamo, Maria Lankinen, Ursula Schwab, Pasi Soininen et autres

BACKGROUND: We investigated with 1HNMR-spectroscopy the effects of habitual fatty fish intake on serum lipiprotein profiles in persons with features of metabolic syndrome.MATERIAL AND METHODS: The ...

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

Ksenia Sevastianova, Alexandre D. Santos, Anna Kotronen, Antti Hakkarainen et autres

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