Zbigniew Kmieć

Fenofibrate Differently Affects the Heart’s Morphology and Metabolism in Young and Old Rats

Agata Wrońska, Jacek Kieżun, Zbigniew Kmieć

Fenofibrate (FF), a lipid-lowering drug, may decrease the risk of cardiovascular diseases in some pathological settings, yet data on its cardiac effects in physiological aging is scarce. To determine FF and age effects on the heart's morphology and expression of metabolism-related genes, …

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The Interplay Between Autophagy and Apoptosis in the Mechanisms of Action of Stilbenes in Cancer Cells

Kamila Siedlecka-Kroplewska, Zbigniew Kmieć, Michal Aleksander Zmijewski

Plant-based stilbenes are low-molecular-weight polyphenolic compounds that exhibit anti-oxidant, anti-microbial, anti-fungal, anti-inflammatory, anti-diabetic, cardioprotective, neuroprotective, and anti-cancer activities. They are phytoalexins produced in diverse plant species in response to stress, such as fungal and bacterial infections or excessive UV irradiation. Plant-derived dietary …

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Reduced Expression of SATB2 in Colorectal Cancer and Its Association with Demographic and Clinicopathological Parameters

Anna Ewa Kowalczyk, Agnieszka Śliwińska-Jewsiewicka, Bartłomiej E. Kraziński, Aleksandra Piotrowska et autres

Special AT-rich sequence-binding protein 2 (SATB2), as a nuclear matrix-associated protein and transcription factor engaged in chromatin remodeling and the regulation of gene expression, plays an important role in growth and development processes. SATB2 has been shown to have tissue-specific expression, also …

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Changes in Systemic Immune Response and Its Dosimetric Correlates in Patients with Non-Small-Cell Lung Cancer Treated with Stereotactic Body Radiation Therapy

Jacek Rutkowski, Zuzanna Nowicka, Tomasz Jerzy Ślebioda, Bartosz Kamil Sobocki et autres

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Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging

Lucyna Kaszubowska, Jan Jacek Kaczor, Mateusz Jakub Karnia, Jerzy Foerster et autres

Introduction: Heme oxygenase-1 (HO-1) is a stress-inducible heat shock protein (HSP32) that exerts cytoprotective effects against oxidative stress and inflammation, and is involved in the maintenance of cellular homeostasis. This study aimed to evaluate the expression of HO-1 in natural killer (NK) …

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Digital morphology network for effective teaching of cytology, histology and histopathology for medical and biology curriculum. VM3.0 Erasmus+ project

Cornelia Amălinei, Andrei Daniel Timofte, Irina-Draga Căruntu, Michal Aleksander Zmijewski et autres

INTRODUCTION: Digital microscopy transformation, the basis for the virtual microscopy applications, is a challenge but also a requirement in modern Medical Education. This paper presents the scope, background, methods, and results of the project "Digital Transformation of Histology and Histopathology by Virtual …

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High-Dose Fenofibrate Stimulates Multiple Cellular Stress Pathways in the Kidney of Old Rats

Agata Wrońska, Jacek Kieżun, Zbigniew Kmieć

We investigated the age-related effects of the lipid-lowering drug fenofibrate on renal stress-associated effectors. Young and old rats were fed standard chow with 0.1% or 0.5% fenofibrate. The kidney cortex tissue structure showed typical aging-related changes. In old rats, 0.1% fenofibrate reduced …

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The role of galanin in the progression and prognosis of colorectal cancer: the unfinished story

Zbigniew Kmieć, Jacek Kieżun, Bartłomiej E. Kraziński, Przemysław Kwiatkowski et autres

The paper presents a summary of immunohistochemical (IHC) and biochemical investigations on the presence of galanin (Gal), one of the neuropeptides abundant in the enteric nervous systems, and three types of its receptors (GalR1-3) in colorectal cancer (CRC) tissue and non-involved colon …

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Impaired Expression of the Salvador Homolog-1 Gene Is Associated with the Development and Progression of Colorectal Cancer

Anna Ewa Kowalczyk, Bartłomiej E. Kraziński, Aleksandra Piotrowska, Jędrzej Grzegrzółka et autres

Salvador homolog-1 (SAV1) is a component of the Hippo pathway that regulates tissue growth and homeostasis by affecting diverse cell processes, including apoptosis, cell division, and differentiation. The aberrant expression of Hippo pathway components has been observed in various human cancers. This …

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The immunoreactivity of GLI1 and VEGFA is a potential prognostic factor in kidney renal clear cell carcinoma

Anna Kotulak‐Chrząszcz, Jacek Kieżun, Mateusz Czajkowski, Marcin Matuszewski et autres

Kidney renal clear cell carcinoma (KIRC) is the most common type of kidney cancer and its pathogenesis is strongly associated with VHL-HIF-VEGF signaling. SHH ligand is the upstream SHH pathway regulator, while GLI1 is its major effector that stimulates as a transcription …

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Cholinergic signaling influences the expression of immune checkpoint inhibitors, PD-L1 and PD-L2, and tumor hallmarks in human colorectal cancer tissues and cell lines

Nyanbol Kuol, Janusz Godlewski, Zbigniew Kmieć, Sara Vogrin et autres

BACKGROUND: Cancer cells express immunosuppressive molecules, such as programmed death ligands (PD-L)1 and PD-L2, enabling evasion from the host's immune system. Cancer cells synthesize and secrete acetylcholine (ACh), acting as an autocrine or paracrine hormone to promote their proliferation, differentiation, and migration. …

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WNT4 Gene and Protein Expression in Endometrial Cancer and Its Significance

Jolanta Kiewisz, Tomasz Waśniewski, Jacek Kieżun, Agnieszka Skowrońska et autres

Background: The inappropriate action of WNT4 and estrogens affects uterine homeostasis and function, and may lead to endometrial cancer (EC). Objective: The aim was to evaluate the alterations of WNT4 gene expression and WNT4 protein immunoreactivity (Ir) in EC, considering tumor characteristics, …

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