2025
conference-abstract
OpenAlex
James T. England, Michelle Geddes, Mitchell Sabloff, Grace Christou et autres
Abstract Background Myelodysplastic neoplasms (MDS) are a group of clonal malignancies of hematopoietic stem cells where progressive cytopenias and potential progression to secondary Acute Myeloid Leukemia (AML) lead to significant morbidity/mortality, impaired quality-of-life (QoL), and healthcare resource burden. Patients with higher-risk MDS …
ca
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2025
conference-abstract
OpenAlex
Nicholas L.J. Chornenki, Lisa Chodirker, Lee Mozessohn, Signy Chow et autres
Abstract Background: Myelodysplastic syndrome (MDS) is a clonal hematologic disorder characterized by cytopenias and a risk of progression to leukemia. Frailty, a state of reduced physiologic reserve, is prevalent among older individuals and is common in patients with MDS. MDS specific frailty …
ca
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Accès ouvert
2025
article
OpenAlex
Lucie Roussel, Stephane Bernier, Gertruda Evaristo, Anna Pérez et autres
Introduction: ) deficiency causes radiosensitive severe combined immunodeficiency (SCID), although hypomorphic cases can manifest later-onset immunodeficiency, autoimmunity, or lymphoproliferation. We report a 45-year-old man with humoral immunodeficiency, opportunistic infections, and recurrent EBV-positive diffuse large B-cell lymphoma (DLBCL). Methods: gene. Functional studies, including …
ca
(code pays fourni par la source)
2024
article
OpenAlex
Betty Wan, Shabbir M.H. Alibhai, Lisa Chodirker, Lee Mozessohn et autres
Myelodysplastic syndromes (MDSs) treatment focuses on improving quality of life (QOL), affected by anemia and transfusion dependence (TD). Using the MDS-CAN registry, we studied how changes in transfusion status – TD to transfusion independence (TI) (group A), or vice versa (group B), …
ca
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Bo Wan, S. M. H. Alibhai, Lisa Chodirker, Lee Mozessohn et autres
Introduction: Patients with myelodysplastic syndromes (MDS) generally experience inferior quality of life (QOL), in part due to transfusion dependent-anemia and. Many studies have shown that patients who are transfusion dependent (TD) typically have worse QOL compared to patients who are transfusion independent …
ca
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Jia Li Liu, Nushin Sadeghi, Owen Dan Luo, Jonathan How et autres
Background Acute Myeloid Leukemia (AML) is a common form of leukemia in adults. Gemtuzumab Ozogamicin (GO), an anti-CD33 antibody linked to a chemotherapy molecule, demonstrated improved event-free survival (EFS) and overall survival (OS) in favorable and intermediate risk AML when given with …
ca
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Accès ouvert
2024
conference-abstract
OpenAlex
Veronica Ramirez, Gizelle Popradi, John M. Storring, Jonathan How
Introduction: Allogeneic hematopoietic stem cell transplant (HCT) is the only curative option for many hematologic malignancies, yet non-relapse mortality (NRM) remains a challenge. Since its development in 2003, the HCT Comorbidity Index (HCT-CI) has been widely adopted to estimate NRM and overall …
ca
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
James T. England, Liying Zhang, Karen Yee, Michelle Geddes et autres
Introduction: Myelodysplastic neoplasms (MDS) are a group of clonal hematopoietic disorders characterized by cytopenias and a risk of progression to Acute Myeloid Leukemia. Frailty is an age-related state of vulnerability that reflects multifactorial loss of physiologic reserve. Up to 25% of patients …
ca
(code pays fourni par la source)
2024
article
OpenAlex
Jean Lachaîne, C. Beauchemin, Fatéma Dodat, Yunghan Au et autres
INTRODUCTION: Acute myeloid leukemia (AML) represents a significant burden for patients and their families, and to the healthcare system. This study estimated the total cost of illness associated with newly diagnosed AML patients in Canada. METHODS: The economic burden of AML was …
kr, ca
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Accès ouvert
2023
article
OpenAlex
Rena Buckstein, Lisa Chodirker, Karen Yee, Michelle Geddes et autres
Many patients with lower-risk myelodysplastic syndromes (LR MDS) require long-term red blood cell (RBC) transfusions to manage anemia. The consequences of RBC transfusions in LR MDS with ring sideroblasts (LR MDS-RS) are not well known. We estimated the association between cumulative RBC …
ca, us
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Accès ouvert
2022
article
OpenAlex
Rena Buckstein, Lisa Chodirker, Lee Mozessohn, Karen Yee et autres
Patients with lower-risk (LR) myelodysplastic syndromes (MDS) with ring sideroblasts (RS) have better prognosis than those without RS, but how they fare over time is not fully understood. This study’s objective was to assess the natural history of LR MDS with RS …
ca, us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Jennifer Teichman, Michelle Geddes, Nancy Zhu, Mary‐Margaret Keating et autres
Iron overload (IO) reflected by elevated ferritin is associated with increased mortality in myelodysplastic syndromes (MDS), however, ferritin is an imperfect metric. Elevated labile plasma iron correlates with clinical outcomes and transferrin saturation (TSAT) >80%, but is not readily measurable. The trajectory …
ca
(code pays fourni par la source)