Michelle L. Wiese

Treatment of Unicameral Bone Cysts Utilizing the Sclerograft™ Technique

Shankar Rajeswaran, Michelle L. Wiese, Julie Chesterton, Jonathan D. Samet et autres

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Uso de redes sociais por cirurgiões com treinamento especializado em trauma ortopédico

Haley E. Smith, Colin K. Cantrell, Cody Goedderz, Michelle L. Wiese et autres

Resumo Objetivo: Quantificar o uso de plataformas de rede social por traumato-ortopedistas, com ênfase nas diferenças demográficas, regionais e de tipo de prática clínica. Materiais e Métodos: Utilizando o banco de dados de membros da Orthopaedic Trauma Association (OTA), foram realizadas pesquisas …

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Postpartum Psychosis: A Preventable Psychiatric Emergency

Ramanpreet Toor, Michelle L. Wiese, Carmen Croicu, Amritha Bhat

Postpartum psychosis is the most severe psychiatric disorder associated with childbirth. Although rare, it is considered a psychiatric emergency that warrants immediate medical attention and inpatient care to ensure safety, complete diagnostic evaluation, and treatment initiation. This article describes the phenomenology of …

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New-Onset Paralysis following Biopsy of a Retroperitoneal Mass with Intraspinal Extension in a Pediatric Patient

Michelle L. Wiese, Shankar Rajeswaran

Image-guided percutaneous biopsies are routine, safe procedures and complications are infrequent and usually directly related to the biopsy itself. This report describes a biopsy of a retroperitoneal mass with extension into the spinal canal, following which the patient developed paralysis unrelated to …

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Data from Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity

Prabhani U. Atukorale, Shruti Raghunathan, Vanitha Raguveer, Taylor J. Moon et autres

Abstract Effective cancer immunotherapy depends on the robust activation of tumor-specific antigen-presenting cells (APC). Immune agonists encapsulated within nanoparticles (NP) can be delivered to tumor sites to generate powerful antitumor immune responses with minimal off-target dissemination. Systemic delivery enables widespread access to …

Supplementary Data from Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity

Prabhani U. Atukorale, Shruti Raghunathan, Vanitha Raguveer, Taylor J. Moon et autres

SF1: IFNβ production from macrophages by ELISA analysis; SF2: FMT imaging of mammary tumors ex vivo for spatial localization of nanoparticle; SF3: Confocal micrographs of DiI-nanoparticle fluorescence in mammary tumor tissue; SF4: Representative images of tumor masses 4 days post-treatment; SF5: Primary …

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Supplementary Data from Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity

Prabhani U. Atukorale, Shruti Raghunathan, Vanitha Raguveer, Taylor J. Moon et autres

SF1: IFNβ production from macrophages by ELISA analysis; SF2: FMT imaging of mammary tumors ex vivo for spatial localization of nanoparticle; SF3: Confocal micrographs of DiI-nanoparticle fluorescence in mammary tumor tissue; SF4: Representative images of tumor masses 4 days post-treatment; SF5: Primary …

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Data from Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity

Prabhani U. Atukorale, Shruti Raghunathan, Vanitha Raguveer, Taylor J. Moon et autres

Abstract Effective cancer immunotherapy depends on the robust activation of tumor-specific antigen-presenting cells (APC). Immune agonists encapsulated within nanoparticles (NP) can be delivered to tumor sites to generate powerful antitumor immune responses with minimal off-target dissemination. Systemic delivery enables widespread access to …

(PO-136) The relationship Between Glycemic Control and Food Insecurity in People with Diabetes Mellitus and Comorbid Psychosis

Michelle L. Wiese

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Comparison of the uptake of untargeted and targeted immunostimulatory nanoparticles by immune cells in the microenvironment of metastatic breast cancer

Gil Covarrubias, Taylor J. Moon, Georgia Loutrianakis, Haley M. Sims et autres

integrin and P-selectin that are commonly used to direct nanoparticles to tumors. Using the 4T1 mouse model, we assessed the microdistribution of the four NP variants in the tumor immune microenvironment in three different breast cancer landscapes, including primary tumor, early metastasis, …

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Immunostimulatory silica nanoparticle boosts innate immunity in brain tumors

Peter A. Bielecki, Morgan E. Lorkowski, Wyatt M. Becicka, Prabhani U. Atukorale et autres

T cell activity (2.5-fold) and delayed GBM tumor growth. We show that an engineered immunostimulatory nanoparticle can support pro-inflammatory innate immune function in GBM and subsequently augment current immunotherapeutic interventions and improve their therapeutic outcome.

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Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity

Prabhani U. Atukorale, Shruti Raghunathan, Vanitha Raguveer, Taylor J. Moon et autres

Effective cancer immunotherapy depends on the robust activation of tumor-specific antigen-presenting cells (APC). Immune agonists encapsulated within nanoparticles (NP) can be delivered to tumor sites to generate powerful antitumor immune responses with minimal off-target dissemination. Systemic delivery enables widespread access to the …

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