Qin Feng Gao

Exploring the Role of the LCN2–DHODH Interaction in Mitochondrial Ferroptosis During Sepsis-Induced Myocardial Injury and LPS-Induced HL-1 Cardiomyocyte Injury

Lu Li, Yuping Li, Yixuan Hao, Mengjie Yu et autres

This study aimed to investigate the regulatory effect of lipocalin-2 (LCN2) knockdown on DHODH-mediated mitochondrial ferroptosis in sepsis-induced myocardial injury (SIMI) and clarify the underlying STAT3-related molecular mechanism in a cecal ligation and puncture (CLP) mouse model and lipopolysaccharide (LPS)-stimulated HL-1 cardiomyocyte …

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Aldehyde Dehydrogenase‐2 Alleviates Septic Myocardial Injury by Inhibiting Caspase‐11‐Mediated Noncanonical Pyroptosis

Huan Liang, Yuying He, Yiren Wang, Rui Zhang et autres

Purpose The purpose of this study is to investigate the role of aldehyde dehydrogenase‐2 (ALDH2) in septic myocardial injury, focusing on noncanonical pyroptosis. Methods In vivo, C57BL/6J mice were divided into five groups: Sham, cecal ligation and puncture (CLP), CLP + Alda‐1 …

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Quercetin relaxes rat pulmonary arteries and trachea ex vivo: Role of nitric oxide and K⁺ channels

Hongyan Sun, Min Xu, Ziyi Chen, Ying Tang et autres

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Anthocyanins: a comprehensive review of their chemical properties and health impacts on glucose metabolism in Gestational Diabetes Mellitus

Gabriela Maria Villagrán Escobar, Li Li, Wenlin Cheng, Zixuan Li et autres

Abstract Gestational diabetes mellitus (GDM) is a prevalent metabolic condition associated with pregnancy, defined by reduced glucose tolerance and insulin resistance (IR), which may have long-term consequences for both mother's and offspring's health.Recent evidence highlights the critical role of natural bioactive compounds, …

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[Cinnamic acid ameliorates doxorubicin-induced myocardial injury in mice by attenuating cardiomyocyte ferroptosis via inhibiting TLR4].

Yun Kai Qi, Ruifeng Du, Yuying He, Yixin Zhang et autres

OBJECTIVES: To explore the mechanism of cinnamic acid (CA) for improving doxorubicin-induced myocardial injury (DIC) in mice. METHODS: Network pharmacology analysis was used to obtain the key targets of CA and DIC. Male C57BL/6J mice were randomized into Sham, DOX, CA (25, …

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Discovery of APS03118, a Potent and Selective Next-Generation RET Inhibitor with a Novel Kinase Hinge Scaffold

Jun Zhong, Wei Xue, Qin Feng Gao, Yongbo Liu et autres

]pyridine hinge-binding scaffold designed to overcome acquired resistance to first-generation selective RET inhibitors (SRIs). By enhancing hydrogen bonding with conserved hinge residues (Glu805, Ala807), APS03118 potently inhibits wild-type RET and diverse resistance mutations, including solvent-front (G810R/S/C), gatekeeper (V804M/L/E), roof (L730I/M), and hinge …

Petrochronological constraints on the late Mesozoic dynamics of paleo-Pacific plate and tectonic transition in Southeast China

Zhijie Zeng, Uzair Siddique, M. Santosh, W. D. Zhou et autres

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MEF-YOLO A deep lightweight model for solving the fine-grained of organoid

Hanwen Zhang, Qin Feng Gao, Wentao Zheng, Xuan Huang et autres

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Mitochondrial DNA leakage and micronucleus formation activate the cGAS–STING pathway in aristolochic acid I-induced nephritis

Lei Yu, Yang Hu, Jing Xi, Ning Yu et autres

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Establishment and characterization of functional sheep endometrial luminal epithelial organoids

Jiahe Guo, Xinai Huang, Rongxin Xia, Qin Feng Gao et autres

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ALDH2 Attenuates Blood-Brain Barrier Injury Induced by Cerebral Ischemia/Reperfusion via Alleviating ROS/NLRP3 Inflammasome Axis

Jie Gao, Liya Wang, Meng Qin, Siyu Sun et autres

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The Geophysical and Seismotectonic Implications of the Partial Subduction of the Ogasarawa Plateau on the Southern Izu‐Bonin Arc‐Trench System

Peter Sangana, Qin Feng Gao, Zilong Li

ABSTRACT The present‐day structure of the southern Izu‐Bonin arc‐trench system appears to have been influenced by the partial subduction of the Ogasawara Plateau beneath the Philippine Sea Plate, which has significant tectonic consequences. Unfortunately, there is insufficient information regarding the effects of …

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