ZV Varga

Inflammasome pathway component expressions in myocardial samples of advanced heart failure patients treated with novel heart failure pharmacotherapies

Dávid Nagy, Zsófia Onódi, Andrea Kovács, Tímea Bálint et autres

BACKGROUND: The inflammasome pathway has been implicated in the progression of heart failure (HF). Preclinical studies suggest that angiotensin receptor-neprilysin inhibitor (ARNi) and sodium-glucose cotransporter-2 inhibitor (SGLT2i) therapies may attenuate inflammasome activation, yet evidence in the failing human myocardium remains sparse. Hence, …

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The Many Layers of Membrane Biophysics: Environment-Sensitive Fluorophores Report on Structural Organization of Biological Membranes at Various Depths

Florina Zákány, Rosemary Chandrakanthi Kothalawala, Olivér Pavela, Lajos Szente et autres

Molecular-order-related membrane biophysical properties contribute to the functional modulation of transmembrane proteins, and therefore, their changes due to a modified membrane composition in diseases associated with alterations in lipid levels may play important pathophysiological roles. In living cells, membrane biophysics can be …

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Impact of membrane-lipid additives on the structure and morphology of nanoerythrosomes

Attila Bóta, Teréz Kiss, András Wacha, Kinga Ilyés et autres

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Cryopreservation of Red-Blood-Cell-Derived Extracellular Vesicles

Kinga Ilyés, Tasvilla Sonallya, Judith Mihály, Anikó Gaál et autres

High Resolution Image Download MS PowerPoint Slide Extracellular vesicles (EVs) are crucial in many physiological and pathological processes, and therefore, they are increasingly studied for their potential as diagnostic biomarkers, therapeutic agents, and drug carriers. Red-blood-cell-derived EVs (REVs) have gained particular interest …

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The Selective DHCR24 Blocker SH42 Inhibits ACE2 Binding and Cellular Entry of SARS-CoV-2 Spike Proteins More Efficiently Than Atorvastatin

Tamas Kovacs, Kitti Kurtan, Bernadett Pályi, Zoltán Kis et autres

ACE2 binding of spike proteins and concomitant viral uptake are the first and most decisive membrane-coupled events of SARS-CoV-2 infection, which rely on cholesterol-rich lipid raft microdomains of the host cell plasma membrane. Therefore, lowering membrane cholesterol levels may combat the infection, …

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Myocardial expression of immune checkpoint molecules in patients with advanced heart failure

Tamás G. Gergely, Tamás Kovács, Zsombor I. Hegedűs, Zsófia Onódi et autres

Abstract Introduction Immune checkpoints (ICs) are key regulatory molecules of the adaptive immune response. Immune checkpoint inhibition (ICI) is a novel, revolutionary strategy for the treatment of many cancer types. However, ICIs can lead to various immune-related adverse events, including cardiovascular toxicities, …

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Prior cardiac ischemic injury exacerbates immune checkpoint inhibitor-induced cardiotoxicity

ZV Varga, Tamás G. Gergely, Zsófia D. Drobni, Tamás Kovács et autres

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Momentum grant of the Hungarian Academy of Sciences Introduction Immune checkpoint inhibitors (ICI), such as monoclonal antibodies targeting programmed death ligand-1 (PD-1), revolutionized cancer treatment. However, …

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Rictor is a central target of the molecular network of cardiac ProtectomiRs

András Makkos, Bence Ágg, ZV Varga, Zoltán Giricz et autres

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Research, Development and Innovation Office of Hungary (NKFIA; NVKP-16-1-2016-0017 National Heart Program and OTKA-FK 134751); MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, …

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Immune checkpoint inhibition with PD-1 inhibitor induces cardiac dysfunction without overt myocarditis in C57BL/6J mice

T Gergely, Dániel Kucsera, VE Toth, Balázs Petrovich et autres

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 739593 “Semmelweis 250+ Kiválósági PhD Ösztöndíj” (EFOP-3.6.3-VEKOP-16-2017-00009) Gedeon Richter Talentum Foundation’s scholarship Background Immune checkpoint …

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Transcriptomic analysis and comparative characterization of rat H9C2, human AC16 and murine HL-1 cardiac cell lines

Z Gulyas-Onodi, Tamás Visnovitz, Anna Koncz, Balázs Váradi et autres

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Union's Horizon 2020 research and innovation programme National Research, Development and Innovation Fund of Hungary Background Cardiac cell lines and primary cell cultures are widely used …

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Investigation of cardiotoxicity by dipeptidyl-peptidase-4 inhibitors in a human cardiomyocyte cell line as well as in samples from chronic heart failure patients

Imre Vörös, ZS Onodi, VE Toth, T Gergely et autres

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): Horizon 2020 research and innovation programme, Ministry for Innovation and Technology Background Dipeptidyl-peptidase-4 (DPP4) inhibitors are relatively new therapeutic tools for type 2 diabetes. The SAVOR-TIMI-53 clinical …

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Evaluation of the interplay between NASH and HFpEF in varied murine age groups

Dániel Kucsera, Nabil V. Sayour, Mihály Ruppert, Tamás Radovits et autres

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Union's Horizon 2020 Research and Innovation Programme, grant agreement no. 739593 New National Excellence Program of the Ministry of Human Capacities (ÚNKP-21-3-II) Introduction Heart failure with …

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